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简介：ObjectivesToanalyzethesix-minutewalktest(6MWT)andgasexchangeof5hearttransplantationpatientsandtoapproachthevariationtendencyofexercisetolerance,oxygenuptake(VO2)andheartratechronotropicresponse.Methods5casesofhearttransplantationpatients(age25～52years)wereundertaken6MWT6～30monthsafteroperation,synchronizinggasexchangingparametersweremeasuredbywirelessportableremotesensingK4B2gasanalyzer,51normalcontrolswerecompared.ResultsThesix-minutewalkdistance(6MWD)of5patientswere(592.6±26.7)m(558～625)m,theascendingtendencyduringexercisewasslower,themaximumheartrateswere80%±6%ofage-predictingmaximalheartrate,lowerthannormalcontrol(86%);theendpointVO2/kgwere(21.8±1.4)mL/min·kg(19.94～23.60)mL/min·kg.ConclusionsThe6WMDandVO2of5patientsreachednormalrange,buttheheartratechronotropicresponseandVO2ascendingtendencywereslowerthanthoseofnormalcontrols.

简介：Percutaneouscoronaryintervention(PCI)improvessymptomsandprognosisinischemia-inducing,functionallysignificant,coronarylesions.Useoffractionalflowreserveallowsphysicianstoinvestigatetheischemia-inducingpotentialofaspecificlesionandcanbeusedtoguidecoronaryrevascularization,especiallyinmultivesselcoronaryarterydisease.Fractionalflowreserve-guidedPCIhasbeenextensivelyinvestigated.Resultsshowthatdeferralofstentinginnon-significantlesionsissafe,whereasdeferralofstentinginfunctionallysignificantlesionsworsensoutcome.FFR-guidedPCIimprovesoutcomeinmultivesseldiseaseoverangiography-guidedPCI.Untilrecently,therewaslittleknownaboutthelong-termoutcomeofFFR-guidedrevascularizationanditsvalidityinacutecoronarysyndromes.Thisreviewaimstoaddressthenewevidenceregardinglong-termappropriatenessofFFR-guidedPCI,theneedforhyperemiatoevaluatefunctionalseverity,andtheuseofFFRinacutecoronarysyndromes.

简介：ObjectivesToassesstherelationshipbetweenpeakoxygenconsumption(PVO2)andtheambulationdistanceinsix-minutewalktest(6MWT)amongthehealthysubjects.MethodsThe51healthysubjectswererecruitedforthesix-minutewalktest.Dataofpulmonarygasexchangebreathbybreath,suchasVO2,VCO2werereal-timemeasuredwithwirelessremotesensingK4B2,sotostudytherelationshipbetweenpeakoxygenuptakeandtheambulationdistance.ResultsItwasnoticedthattherewasapositivelinearcorrelationbetweentheambulationdistanceandPVO2(r=0.619,P<0.001)insix-minutewalktest.Theregressionequationwassetup(VO2/kg=0.05D-6.331,P<0.001).PVO2>PVCO2,R<1werefound,whichsuggestedthat6MWTwasatestbelowanaerobicthreshold.ConclusionsTherewasacloselypositivelinearcorrelationbetweentheambulationdistanceandPVO2,whichissafety,convenientandvaluablefortheevaluationofcardiopulmonaryfunctionandthetreatmentofcardiopulmonaryrehabilitation.

简介：BackgroundTheCHA2DS2-VAScschemahasrecentlybeenintroducedtocomplementtheCHADS2scoreandimprovetheidentificationofatrialfibrillation(AF)patientsat'trulylowrisk'forthromboembolism.WetestedthepredictiveabilityoftheCHA2DS2-VASc,CHADS2andvanWalravenriskstratificationschemesinacohortof'lone'AFpatientswitha12-yearfollow-up.MethodsandResultsWeconductedaregistry-based,observationalcohortstudyof345patientsinitiallydiagnosedwith'lone'AFbetween1992and2007.Atbaseline,allpatientshadtheCHADS2andvanWalravenscoresof0,and262(75.9%)hadaCHA2DS2VAScscore=0.Duringfollow-up(orwithinayearpriortostroke),228(66.1%),234(67.8%)and150patients(43.5%)retainedtheCHADS2,vanWalravenandCHA2DS2VAScscoresof0,respectively.Theoverallrateofischemicstrokewas0.19(95%CI:0.18-0.20)per100patient-years.Inthemultivariableanalysis,onlytheCHA2DS2-VAScscoreof0wassignificantlyrelatedtotheabsenceofstroke(OR5.1,95%CI:1.5-16.8,P=0.008).OnlytheCHA2DS2-VAScscorehadasignificantpredictionability(c-statistic0.72[0.61-0.84],P=0.031).ConclusionsTheCHA2DS2-VAScscorereliablyidentifiedthe'lone'AFpatientswhowereat'trulylowrisk'forthromboembolism,andwastheonlytestedriskstratificationschemewithasignificantpredictiveabilityforthromboembolismamongstloneAFpatients.