简介:目的:比较无菌空气填充和C_3F_8填充在玻璃体切割(PPV)联合内界膜瓣(ILMF)覆盖术中治疗特发性黄斑裂孔(IMH)的疗效差异。方法:回顾性对照研究。选取武汉大学人民医院眼科2014-01/2017-06就诊的符合纳入标准的IMH患者,行PPV联合黄斑区ILMF翻转覆盖黄斑裂孔术,根据术中是否行C_3F_8填充,分为球内空气填充组(A组112眼)和球内C_3F_8填充组(B组63眼),比较两组术后高眼压发生情况、黄斑裂孔闭合率、术后1、3mo时最佳矫正视力(BCVA)和黄斑区结构重建情况。结果:A组和B组在术后1、3mo时,较术前BCVA均有提高,差异有统计学意义(P〈0.05);两组手术后1mo时BCVA比较差异均无统计学意义,术后3mo时,A组BCVA较B组恢复更佳,差异具有统计学意义(P〈0.05);A组黄斑裂孔闭合率为97.5%,B组为96.8%,两组比较差异无统计学意义;两组的光感受器细胞内外节交界面连接带(EZ)缺损直径较术前均有明显减小,差异有统计学意义(P〈0.05),在术后1、3mo时两组比较,差异均无统计学意义;B组术后高眼压发生率为9.5%,而A组无术后高眼压情况发生,两者差异有统计学意义(P〈0.05)。结论:PPV联合ILMF覆盖治疗特发性黄斑裂孔安全有效,玻璃体腔无菌空气填充可减少术后高眼压发生率,在该手术中可以代替C_3F_8填充。
简介:目的:探讨单侧内直肌截除术治疗儿童残余性和复发性外斜视的有效性及安全性,评价其在不同外斜视类型及不同初次手术方式应用的差异性。方法:回顾性病例系列研究。收集2009-01/2013-02在山东大学附属山东省立医院行单侧内直肌截除术治疗的残余性和复发性外斜视连续性病例48例48眼,观察术后第Id,6wk以及末次随访(术后6~32mo)时患儿眼位、眼位非共同性、融合功能及立体视锐度情况。结果:术后第Id手术正位率为83%(40/48),欠矫率为4%(2/48),过矫率为13%(6/48);术后第6wk手术正位率为81%(39/48),欠矫率为13%(6/48),过矫率为6%(3/48);末次随访时正位率为75%(36/48),欠矫率为25%(12/48),无1例过矫。不同初次手术方式和不同外斜视类型患儿末次随访时手术正位率的差异均无统计学意义(P=0.168、0.50)。术后所有病例均未出现眼球运动非共同性和眼球外转受限。结论:单侧内直肌截除术是治疗儿童残余性和复发性外斜视的安全有效术式,其在不同外斜视类型及不同初次手术方式应用的疗效无差异。
简介:目的比较两种不同药物低分子肝素钠与肝素钠皮内注射治疗眼睑黄色瘤的疗效分析。方法将34例眼睑黄色瘤患者(28例双眼,6例单眼),等分成两组(每组14例双眼,3例单眼):低分子肝素钠组瘤体面积(32.06±11.20)mm^2,肝素钠组瘤体面积(31.68±10.34)mm^2(t=-0.164,P=0.871),两组间瘤体大小差异无统计学意义。两组均严格采取皮内注射方法,一组皮内注射低分子肝素钠,另一组则皮内注射肝素钠,观察其疗效和疗程以及不良反应和并发症。结果两种药物皮内注射均能取得满意的临床疗效,但低分子肝素钠见效快、疗程短,且皮下淤血发生率明显降低。结论低分子肝素钠皮内注射治疗眼睑黄色瘤具备更优的临床效果。
简介:Thedamageofhumancornealcellsencounterwiththeproblemofavailabilityofcornealcellsforreplacement.Limitationofthesourceofcornealcellshasbeenrealized.Anattemptofdevelopmentofcornealepithelial-likecellsfromthehumanskin-derivedprecursor(hSKPs)hasbeenmadeinthisstudy.Combinationofthreeessentialgrowthfactors:epidermalgrowthfactor(EGF),keratinocytegrowthfactor(KGF)andhepatocytegrowthfactor(HGF)coulddemonstratesuccessfullyinductionofhSKPstodifferentiationintocornealcells.Theinducedcellsexpressedtheappearanceofmarkersofcornealepithelialcellsasshownbythepresenceofkeratin3(K3)byantibodylabelandWesternblotassay.TheK3geneexpressionofinducedhSKPscellsasshownbyreversetranscription-polymerasechainreaction(RT-PCR)technologywasalsodemonstrated.ThepresenceofthesemarkersatbothgeneandproteinlevelscouldleadtoourconclusionthatthedirectionaltransdifferentiationofhSKPscellsintocornealepithelialcellswassuccessfullydoneunderthiscellinductionprotocol.Thefindingshowsanewlyavailablestemcellsourcecanbeobtainedfromeasilyavailableskin.Cellsfromautologoushumanskinmightbeusedforcornealdisordertreatmentinfutureclinicalapplication.
简介:AIM:Toinvestigatethediffusioncharacteristicsofwaterofopticnerveandopticradiationinhealthyadultsanditsrelatedfactorsbydiffusiontensorimaging(DTI)at3T.METHODS:Atotalof107healthyvolunteersperformedheadconventionalMRIandbilateralopticnerveandopticradiationDTI.TheprimarydataofDTIwasprocessedbypost-processingsoftwareofDTIstudio2.3,obtainingfractionalanisotropyvalue,meandiffusivityvalue,principalenginevalue,orthogonalenginevaluebymeasuring,andanalyzedbytheSPSS13.0statisticalsoftware.RESULTS:Thebilateralopticnerveandopticradiationfiberspresentedgreencolorindirectionalencodedcolor(DEC)mapsandpresentedhighsignalinfractionalanisotropy(FA)maps.TheFAvalueoftheleftopticnervewas0.598±0.069andtherightwas0.593±0.065;themeandiffusivity(MD)valueoftheleftopticnervewas(1.324±0.349)×10-3mm2/sandtherightwas(1.312±0.350)x10-3mm2/s;theprincipalenginevalue(λ?)oftheleftopticnervewas(2.297±0.522)×10-4mm2/sandtherightwas(2.277±0.526)×10-3mm2/s;theorthogonalenginevalue(λ⊥)oftheleftopticnervewas(0.838±0.285)×10-3mm2/sandtherightwas(0.830±0.280)×10-3mm2/s;theFAvalueoftheleftopticradiationwas0.636±0.057andtherightwas0.628±0.056;themeandiffusivity(MD)valueoftheleftopticradiationwas(0.907±0.103)×10-3mm2/sandtherightwas(0.889±0.125)×10-3mm2/s;theprincipaleigenvalue(λⅡ)oftheleftopticradiationwas(1.655±0.210)×10-3mm2/sandtherightwas(1.614±0.171)×10-3mn2/s;theorthogonalenginvalue(λ⊥)oftheleftopticradiationwas(0.531±0.103)×10-3mm2/sandtherightwas(0.524±0.152)×10-3m