简介：拥有做位置的不同Ce的Pd和PdPt催化剂的物理化学的性质被TEM，XRD，N2吸附解吸附作用，XPS和英尺红外的技术调查。为甲醇总数氧化的催化表演被检验学习增加位置的Ce的效果。CeO2艾尔2O3Ce直接被介绍进支持的TiO2(猫)催化剂比CeO2/Al22选择>O3Ce被受精在装载的TiO2(Ce/AT)样品方法。描述结果表明做位置的Ce不引起基本水晶的阶段的明显的另一和支持的mesoporous结构。然而，做位置的Ce影响支持的毛孔形状然后影响毛孔直径。猫催化剂拥有更丰富的吸附的氧和更多Ti3+能在催化剂表面上把更气体的氧转变成活跃的氧种类，它对反应有益。在猫的AlOTi桥便于艾尔和Ti种类的合作，它进一步加快反应率。

简介：

简介：Weemployedametallicwiregratingloadedwithgrapheneandoperatingintotalinternalreflection(TIR)geometrytorealizedeepandbroadbandTHzmodulation.Thenon-resonantfieldenhancementeffectoftheevanescentwaveinTIRgeometryandinthesubwavelengthwiregratingwascombinedtodemonstratea-77%modulationdepth(MD)inthefrequencyrangeof0.2–1.4THz.ThisMD,achievedelectricallywithaSiO2∕Sigatedgraphenedevice,was4.5timeshigherthanthatofthedevicewithoutametalgratingintransmissiongeometry.Byoptimizingtheparametersofthemetallicwiregrating,therequiredsheetconductivityofgraphenefordeepmodulationwasloweredto0.87mS.ThisworkhaspotentialapplicationsinTHzcommunicationandreal-timeTHzimaging.

简介：

简介：BackgroundThepresenceofachronictotalocclusion(CTO)inanon-infarct-relatedarterymightbeassociatedwithaworseprognosisinlongtermbenefitforST-segmentelevationmyocardialinfarction(STEIMI)patients.Butitstillremaincontroversial.MethodsAll383STEMIpatientsunderwentpercutaneousintervention(PCI)fromJan2015toJan2017inourcenterwereenrolledinthisprospectivestudy.Baselinecharacteristics,medicalhistory,biochemicalfindings,echocardiographicandangiographicparameters,proceduresperformedandcomplicationswererecorded.FactorsrelatedtoworseoutcomeCTOinSTEMIpatientswereanalyzedbythecoxlogisticregressionanalysisforthehazardrate(HR).ResultsInatotalof383patientsenrolledinthisstudy,85caseshadCTOinatleast1coronaryartery.Themeanfollow-upwas352days.1-yearmortalityandMACEratesinpatientswithCTOwere18.8%and11.8%,respectively.Majoradversecardiacevents(MACE)duringfollow-upweresignificantlyhigherinpatientswithCTO(HR=2.88;95%CI,1.82-4.77;P<0.001).ThemultivariateanalysisshowedasignificantassociationbetweenCTOandMACE(HR=2.1195%CI,1.27-3.88;P=0.014).ConclusionChronictotalocclusionisassociatedwithhigherriskofcomorbiditiesandhighermortality,andservesasanindependentpredictorofMACE.

简介：Purpose：Theaimofthisstudywastoinvestigatetheinfluenceofthecardiorespiratoryfitnesslevelontheresponsetohigh-intensityintervaltraining（HIIT）withanindividuallyadjustedrunningspeedofthesamerelativeintensity.Theevaluationfocusedonacutecardiorespiratoryresponse,postexercisecardiacautonomicmodulation（heartratevariability（HRV））andbiochemicalmarkersofinflammation,oxidativestress,andmuscledamage.Methods：Thirtyparticipantsweredividedinto3subgroups：welltrained,moderatelytrained,anduntrained.Alltheparticipantsperformed30minHIITcomposedof6×2minintervalexercisewithwork-to-reliefratio=1andworkintensity100%ofindividualvelocityatmaximaloxygenconsumption（VO2max）.Acutecardiorespiratoryvariables,postexerciseHRV,lactate,interleukin-6（IL-6）,totalantioxidantcapacity（TAC）,creatinekinase,andmyoglobinupto4hafterHIITweremonitored.Results：Thedifferencesinrelativelyexpressedcardiorespiratoryvariables（heartrate,VO2）duringHIITwereatmostmoderate,withthemostpronouncedbetween-groupdifferencesinabsoluteVO2values.ThedisruptionofthepostexerciseHRVwasthemostpronouncedinuntrainedindividuals,andthisdifferencepersisted1hafterHIIT.ThehighestpostexerciseIL-6andTACconcentrationsandthelowestchangesincreatinekinaseandmyoglobinwererevealedinwell-trainedindividuals.Conclusion：Thehigherfitnesslevelwasassociatedwiththelesspronouncedpostexercisecardiacautonomicchangesandtheirfasterrestoration,evenwhenthereweresimilaracutecardiorespiratoryresponses.ThesefindingsweresimultaneouslyaccompaniedbythehigherpostexerciseIL-6andTACconcentrationsandlesssignificantchangesinmuscledamagebiochemicalmarkersinwell-trainedindividuals.

简介：AIMToexploretheprotectiveeffectsandunderlyingmechanismsoftotalpolysaccharidesoftheSijunzidecoction(TPSJ)ontheepithelialbarriersinvitro.METHODSCaco-2cellmonolayersweretreatedwithorwithoutTPSJinthepresenceorabsenceofTNF-α,andparacellularpermeabilityandtransepithelialelectricalresistance(TEER)weremeasuredtoevaluatetheepithelialbarrierfunction.Immunofluorescenceandwesternblottingwererespectivelyusedtoevaluatethedistributionandexpressionofthetightjunctionproteinsclaudin1,claudin2,zo3,andoccludininCaco-2cells.Westernblottingwasalsousedtoevaluatethecellularexpressionofmyosinlightchain(MLC),phosphorylatedMLC(pMLC),MLCkinase(MLCK),andnuclearfactor(NF)-κBp65.RESULTSTPSJpromotedtheproliferationofCaco-2cellsandinhibitedTNF-α-inducedsecretionofpro-inflammatorycytokines.Furthermore,TPSJsignificantlyamelioratedboththereductionofTEERandtheincreasedparacellularpermeabilityobservedintumornecrosisfactor(TNF)-α-damagedCaco-2monolayers.Furthermore,TPSJremarkablyattenuatedTNF-α-inducedmorphologicalchanges,downregulatedtheexpressionofclaudin1,claudin2,zo3,andoccludin,andmarkedlysuppressedTNF-α-mediatedupregulationofp-MLCandMLCKexpression.Finally,TPSJinhibitedtheactivationandexpressionofNF-κBp65.CONCLUSIONOurresultsdemonstratethatTPSJalleviatestheTNF-α-inducedimpairmentoftheintestinalepithelialcellbarrierfunctionbysuppressingNF-κBp65-mediatedphosphorylationofMLCKandMLC.