简介：Echocardiographyisthemostfrequentlyusedimagingmodalitytodeterminecardiacfunction.Leftventricularejectionfractionthemostwidelyusedparameterforevaluationofsystolicfunction,providesimportantprognosticvalueinclinicalpractice,andformspartoftheevidencebaseformanydecisionsaboutcardiovascularcare.However,ejectionfractionhasseveralsubstantiallimitationsandisinsensitivetosubtlechangesinsystolicfunction.Theassessmentofmyocardialdeformationwithechocardiographyhasbeenstudiedfortwodecades,andisincreasinglyusedintheclinicalsetting.Thistechniquecanpreciselycharacterizethemechanicsofmyocardialcontractionandrelaxation.Themostcommonlyusedparameterisgloballongitudinalstrain,whichismoresensitivethanejectionfractionforthemeasurementofsystolicfunction.Thisreviewfocusesontheprognosticvalueofgloballongitudinalstraininpredictingadverseoutcomesincardiovasculardisease.

简介：Positronemissiontomography(PET)isapowerfulnoninvasiveimagingtoolforphenotypingpatientsatriskoforwithknowncoronaryarterydisease(CAD).Oneofthekeyadvantagesoverotherimagingmodalitiesisitsuniqueabilitytoquantifyphysiologicprocesses,includingmyocardialbloodflow(inmillilitersperminutepergramofmyocardium),metabolism,andcardiacreceptors,anditshighsensitivityfordelineatingandquantifyingmoleculartargetsinvivousingtargetedimagingprobes.CardiacPET/CToffersopportunityforacomprehensivenoninvasiveevaluationoftheconsequencesofatherosclerosisinthecoronaryarteriesandthemyocardium.

简介：AIM:Toevaluatewhetherthelevelofthrombospondin-1(TSP-1)inaqueoushumorcanpredicttheprognosisoftrabeculectomyinpatientswithprimaryangle-closureglaucoma(PACG).METHODS:Thiscase-controlstudyinvolved26patientswithPACGwhoexperiencedafailedtrabeculectomy(casegroup)and78age-andsex-matchedpatientswithPACGwhounderwentsuccessfultrabeculectomy(controlgroup).AqueoushumorwascollectedatthetimeoftrabeculectomyandtestedforTSP-1andTGF-β2levelswithanenzyme-linkedimmunosorbentassaymethod.Logisticregressionmodelingwasusedtoassesstheriskfactorsforfailedtrabeculectomy.RESULTS:ThemeanTSP-1aqueousconcentrationsweresignificantlyhigherinthecasegroup(20.67±9.79ng/mL)thanthecontrolgroup(5.17±2.29ng/mL)(P<0.001).Thetransforminggrowthfactor-β2(TGF-β2)aqueousconcentrationsweresignificantlydifferentbetweenthecaseandcontrolgroup,at3633.25and1090.24pg/mL,respectively(P<0.001).LogisticregressionanalysisrevealedTSP-1levelasanindependentriskfactorforafailedtrabeculectomy(OR=3.540;95%CI=1.092-11.482).CONCLUSION:TheaqueoushumorTSP-1andTGF-β2levelsarehigherinPACGeyeswithfailedtrabeculectomythanwithsuccessfultrabeculectomyatoneyear.TheaqueoushumorTSP-1levelisanindependentriskfactorassociatedwithfailedtrabeculectomy.

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简介：ObjectiveToinvestigatetheeffectoffamilytherapyonprognosisofpatientswithschizophrenis.Method200patientsafterdischargingfromhospitalwererandomlydividedintotwogroups:controlgroup(n=100)andexperimentgroup(n=100).Familytherapywasactualizedinpatientsofexperimentgroup.ResultsTherewassignificantdifferenceinpercentofrecurrenceratebetweencontrolgroup(38%)andexperimentgroup(18%,P<0.05).ConclusionFamilytherapymaydecreaserecurrencerateofschizophrenicafterdischargingfromhospital.

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简介：Principalthesesoffocustectoniesandmetallogenyofactiveregion(unlinearmetallogeny)arecloseinspace-genetieaspectes,ageandparticularyinorecontent(tablel).MetallogcnicanalysisofdataondcpositdistributioninthcfoCus8tructurcs(structurcsofCcntraltypc-SCT)andinthcirconccntriczonc8,conductcdonthebaseofSCTidcaa

简介：ＩＮＳＩＴＵＬＡＢＥＬＩＮＧＡＰＯＰＴＯＳＩＳＩＮＢＲＥＡＳＴＣＡＮＣＥＲＡＳＲＥＬＡＴＥＤＴＯＰＲＯＧＮＯＳＩＳＷｕＪｉｏｎｇ吴炅ＳｈａｏＺｈｉｍｉｎ邵志敏ＪｉａｎｇＭｉｎｇ江明ＨａｎＱｉｘｉａ韩企夏ＺｈａｎｇＴｉｎｇｑｉｕ张廷ＳｈｅｎＺｈｅｎｚ...

简介：目的将在hepatocellular癌(HCC)调查cortactin表示并且在HCC病人的预后探索它的意义。方法Immunohistochemistry被执行让119HCC纸巾(HCC)和paratumorous肝纸巾(PTLT)的石蜡样品计算cortactin表达式。在HCC和PTLT的cortactin表示差别被McNemars测试分析。在HCC和clinicopathologic因素的cortactin表情的关系与Mann-WhitneyU测试被分析。Kaplan-Meier方法和木头等级测试被采用比较在Cortactin否定表示组，弱表示组和强壮的表示组之间的全面幸存。cortactin的表示进一步与西方的弄污在19个新鲜HCC和PTLT标本被决定。结果Cortactin表示率在HCC是显著地更高的(53/119，44.5%)比那在PTLT(2/119，1.7%)(P<0.001)。在HCC的upregulatedcortactin表示显著地被相关到形成(P=0.012)，脉管的侵略(P=0.037)和高Edmondson啤酒杯杯分级的囊的缺席(P=0.020)，并且预言了更短的全面幸存。西方的弄污证明那cortactin表情与相应PTLT相比从19HCC(47.4%)是在9的upregulated。结论Cortactin表示是在HCC的upregulated并且与病人的更短的全面幸存有关，建议cortactin可能起在HCC的转移的作用并且预言HCC病人的差的预后。

简介：Dataontheprevalenceofdepressioninadultcongenitalheartdisease(ACHD)patientsdifferwidely.Weaimtosummarizethebestavailableinformationontheprevalenceofdepression,itsprognosticimpact,andpsychiatricinterventionsfordepressedACHDpatients.WereviewedreferencesinrelevantpublicationsuptoOctober17,2017.Forhomogeneityofdata,studiesinwhichdepressionwasindependentlyassessedinpatientsaged18yearsorolderorwithamean/medianageolderthan18yearswereincluded.Retrospectiveandpostoperativeevaluationstudieswereexcluded.Twentypublicationsmetthesecriteria.StudysamplesincludedACHDpatientsfollowedupatACHD-specializedhospitalsin13countries.Theprevalenceofdepressiondifferedwidely,rangingfrom6to69%.Depressionhasbeenshowntobeanindependentpredictorofadverseclinicaloutcomes.Itisalsofrequentlyassociatedwithotherprognosticvariables(i.e.,poorfunctionalclass,unfavorableperceivedhealthstatus,andlowqualityoflife).Currently,norandomizedclinicaltrialsonpsychiatricinterventionsinACHDareavailable.Insummary,depressionishighlyprevalentinACHDpatients,yetitisoftenunrecognizedanduntreated.Theadverseprognosticimpactofdepressioncallsforspecializedpsychiatricinterventions,forwhichmoreresearchisneededintheACHDpatientpopulation.

简介：Epithelialovariancancer(EOC)istheleadingcauseofdeathamongallgynecologicalmalignancies.Despitethetechnologicalandmedicaladvancesoverthepastfourdecades,suchasthedevelopmentofseveralbiologicalmarkers(mRNAandproteinsbiomarkers),themortalityrateofovariancancerremainsachallengebecauseofitslatediagnosis,whichisspecificallyattributedtolowspecificitiesandsensitivities.Underthiscompulsivescenario,recentadvancesinexpressionbiologyhaveshiftedinidentifyinganddevelopingspecificandsensitivebiomarkers,suchasmicroRNAs(miRNAs)forcancerdiagnosisandprognosis.MiRNAsareanovelclassofsmallnon-codingRNAsthatderegulategeneexpressionattheposttranscriptionallevel,eitherbytranslationalrepressionorbymRNAdegradation.Thesemechanismsmaybeinvolvedinacomplexcascadeofcellulareventsassociatedwiththepathophysiologyofmanytypesofcancer.MiRNAsareeasilydetectableintissueandbloodsamplesofcancerpatients.Therefore,miRNAsholdgoodpromiseaspotentialbiomarkersinovariancancer.Inthisreview,weattemptedtoprovideacomprehensiveprofileofkeymiRNAsinvolvedinovariancarcinomatoestablishmiRNAsasmorereliablenon-invasiveclinicalbiomarkersforearlydetectionofovariancancercomparedwithproteinandDNAbiomarkers.

简介：AbstractPurpose:Traumatic brain injury (TBI) is one of the leading causes of disability and death in modern times, whose evaluation and prognosis prediction have been one of the most critical issues in TBI management. However, the existed models for the abovementioned purposes were defective to varying degrees. This study aims to establish an ideal brain injury state clinical prediction model (BISCPM).Methods:This study was a retrospective design. The six-month outcomes of patients were selected as the end point event. BISCPM was established by using the split-sample technology, and externally validated via different tests of comparison between the observed and predicted six-month mortality in validating group. TBI patients admitted from July 2006 to June 2012 were recruited and randomly divided into establishing model group and validating model group. Twenty-one scoring indicators were included in BISCPM and divided into three parts, A, B, and C. Part A included movement, pupillary reflex and diameter, CT parameters, and secondary brain insult factors, etc. Part B was age and part C was medical history of the patients. The total score of part A, B and C was final score of BISCPM.Results:Altogether 1156 TBI patients were included with 578 cases in each group. The score of BISCPM from validating group ranged from 2.75 to 31.94, averaging 13.64 ± 5.59. There was not statistical difference between observed and predicted mortality for validating group. The discrimination validation showed that the BISCPM is superior to international mission for prognosis and analysis of clinical trials (IMPACT) lab model.Conclusion:BISCPM is an effective model for state evaluation and prognosis prediction of TBI patients. The use of BISCPM could be of great significance for decision-making in management of TBI.

简介：BACKGROUND&OBJECTIVE:Themajorityofintramedullaryspinalcordtumors(IMSCT)arelow-gradegliomas.RadicalresectionforIMSCTsremainschallenging.Recently,improvedneuroimagingandadvancedmicrosurgicaltechniquehavemadegreatsuccessinsurgicalmanagementoftheintramedullaryspinalcordtumors.METH-ODS&RESULTS:Twenty-ninepatientswithintramedullaryspinalcordtumorsweretreatedbyradicalresectiondur-ingthepast4yearsinourinstitute.Thehistologicalresultswereasfollows:12ependymomas,4astrocytomas,4heman-gioblastomas,4epidermoids,1cavernoma,2lipomas,2metastatics.Agross-totalresection(>95%)wasachievedin25surgicalprocedures.Subtotalresections(80-95%)wereperformedin4cases.Therewasnosurgicaldeath.Whencomparingthepreoperativeand3-monthpostoperativefunctionalgrades,12patientswerestable14improved,and3deteriorated.Patientswitheithernodeficitoronlymilddeficitbeforesurgerywererarelyimpairedbytheproce-dure,reinforcingtheimportanceofearlydiagnosisandtreatment.Themajordeterminantoflong-termsurvivalwashistologi-calcompositionofthetumor.PatientsinwhomanIMSCTwasonlypartiallyresected(<80%)faredsignificantlyworse.CONCLUSIONS:Thelong-termsurvivalandqualityoflifeforpatientswithlow-gradegliomastreatedbyradi-calresectionaloneiscomparableorsuperiortominimalresectionplusradiotherapy.Theoptimaltherapyforpatientswithhigh-gradegliomaisyettobedetermined.Forbenignlesion,suchashemangioblastomaandcavernomacouldbecuredbytotalresectionofthetumor.Forlipomaandepidermoid,fibrousadhesionstothecordmaketotalremovaldifficult,andthus,removalisnotthegoalofsurgery.Thecarbondioxidelaserisparticularlyusefulduringsurgeryforthislesion.

简介：AbstractBackground:Hypertension is considered an important risk factor for the coronavirus disease 2019 (COVID-19). The commonly anti-hypertensive drugs are the renin-angiotensin-aldosterone system (RAAS) inhibitors, calcium channel blockers (CCBs), and beta-blockers. The association between commonly used anti-hypertensive medications and the clinical outcome of COVID-19 patients with hypertension has not been well studied.Methods:We conducted a retrospective cohort study that included all patients admitted with COVID-19 to Huo Shen Shan Hospital and Guanggu District of the Maternal and Child Health Hospital of Hubei Province, Wuhan, China. Clinical and laboratory characteristics were extracted from electronic medical records. Hypertension and anti-hypertensive treatment were confirmed by medical history and clinical records. The primary clinical endpoint was all-cause mortality. Secondary endpoints included the rates of patients in common wards transferred to the intensive care unit and hospital stay duration. Logistic regression was used to explore the risk factors associated with mortality and prognosis. Propensity score matching was used to balance the confounders between different anti-hypertensive treatments. Kaplan-Meier curves were used to compare the cumulative recovery rate. Log-rank tests were performed to test for differences in Kaplan-Meier curves between different groups.Results:Among 4569 hospitalized patients with COVID-19, 31.7% (1449/4569) had a history of hypertension. There were significant differences in mortality rates between hypertensive patients with CCBs (7/359) and those without (21/359) (1.95% vs. 5.85%, risk ratio [RR]: 0.32, 95% confidence interval [CI]: 0.13-0.76, χ2 = 7.61, P = 0.0058). After matching for confounders, the mortality rates were similar between the RAAS inhibitor (4/236) and non-RAAS inhibitor (9/236) cohorts (1.69% vs. 3.81%, RR: 0.43, 95% CI: 0.13-1.43, χ2 = 1.98, P = 0.1596). Hypertensive patients with beta-blockers (13/340) showed no statistical difference in mortality compared with those without (11/340) (3.82% vs. 3.24%, RR: 1.19, 95% CI: 0.53-2.69, χ2= 0.17, P= 0.6777).Conclusions:In our study, we did not find any positive or negative effects of RAAS inhibitors or beta-blockers in COVID-19 patients with hypertension, while CCBs could improve prognosis.

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简介：AbstractOur study aimed to determine the effect of the neutrophil-lymphocyte ratio on the prognosis of adult patients with acute stroke. We searched the Web of Science, PubMed, Embase, Cochrane Library, and China National Knowledge Infrastructure databases and selected all of the potentially eligible studies. From the included studies, we extracted characteristics such as the stroke type and acquisition time until routine blood collection and the odds ratios across studies. The 95% confidence intervals and odds ratios were pooled to calculate the effect size for the neutrophil-lymphocyte ratio in acute stroke patients. We defined poor function outcomes according to the modified Rankin Scale ≥ 3 or Glasgow Outcome Scale< 3.Thirteen studies with 4443 patients were included in our analysis, including 7 ischemic and 6 hemorrhagic stroke studies. The pooled odds ratios for poor functional outcome at 3 months with a higher neutrophil-lymphocyte ratio in acute ischemic and hemorrhagic patients were 1.689 (95% CI = 1.184-2.409, p < 0.001) and 1.125 (95% CI = 1.022-1.239, p < 0.001), respectively, and the overall pooled odds ratio for poor functional outcome following stroke was 1.257 (95% CI = 1.146-1.379, p < 0.001). At the same time, the overall combined odds ratio for death at 3 months was 1.632 (95% CI = 1.155-2.306, p < 0.001).The neutrophil-lymphocyte ratio, an easily calculated marker, plays a predictive role in the short-term outcomes of adult patients (mean age ≥ 50 years) following acute ischemic and hemorrhagic stroke.

简介：AIM:Toevaluatetheroleofsurvivinandcaspase-3inapoptosisofgastriccarcinoma,aswellasinprognosisofpatientswithgastriccarcinoma.METHODS:Expressionsofsurvivinandcaspase-3wereinvestigatedimmunohistochemicallyin80gastriccarcinomapatientswithoutahistoryofchemo-radiationtherapy.TumorcellapoptosiswasexaminedbyTUNELmethod.RESULTS:Immunohistochemicalanalysisshowedthatsurvivinexpressionwaspositivein61of80patients(76%)withgastriccarcinoma.Incontrast,noexpressionofsurvivininadjacentnormaltissueswasdetected.Expressionlevelofcaspase-3washigherinnormaltissuesthanincarcinoma.Patientswithhigherexpressionofsurvivinhadworsehistologicalgradesandpathologicalstages.Expressionofcaspase-3wassignificantlyassociatedwithhistologicalstages,butnotwiththepathologicalstages.Althoughsurvivinexpressionincarcinomawasnotinverselyrelatedtocaspase-3,patientswithsurvivin(-)andcaspase-3(+)hadthemaximumapoptosisindex.CONCLUSION:Expressionlevelofsurvivinwasassociatedwithhistologicalgradesandpathologicalstagesofthetumor,indicatingthatsurvivinmaybeapoorprognosisfactorforgastriccarcinoma.Unlikecaspase-3,survivin(anapoptosisinhibitor)canmarkedlyinhibittheapoptosisoftumorcells.

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简介：AbstractPurpose:The long-term situation of children with spinal cord injury (SCI) was investigated, and suggestions for helping them better return to the society were provided.Methods:SCI patients less than 18 years old hospitalized in Beijing Boai Hospital from January 2011 to December 2020 were retrospectively analyzed. Information including motor function, complications, characteristic changes, self-care abilities, school attendance and social participation were collected by telephone interview and electronic questionnaire. All the answers were statistically analyzed.Results:A total of 86 cases were enrolled, 77 girls and 9 boys, with a median injury age of 6 years and 2 months. The follow-up time was 3-130 months. The main cause of trauma in these children was sport injury (66.3%), the thoracic spinal cord was involved the most (91.9%), and complete SCIs accounted for the majority (76.7%). In terms of complications, children with complete SCIs were more likely to have urinary incontinence, constipation and characteristic changes (p < 0.05); whereas the incomplete SCIs often have spasticity (p < 0.05). As to the daily living abilities, children with incomplete lumbar SCIs were more capable to accomplish personal hygiene, transfer, and bathing independently than those with complete injuries, or cervical/thoracic SCIs, respectively (p < 0.05). Moreover, children older than 9 years care more able to dress and transfer independently than the youngers (p < 0.05). Wheelchair users accounted for 84.9% and more than half of them were able to propel wheelchair independently, and those who move passively in wheelchairs were mostly introverted kids (p < 0.05). Almost all (93.8%) children with incomplete injuries were able to walk independently. Most (79.1%) children continued to attending school, and 41.9% participated in interest classes. Unfortunately, 67.4% of the children spent less time playing with their peers than before the injury.Conclusion:SCIs impair physical structures and function of children, affect their independence in daily living, and restrict school attendance and social interaction. Comprehensive rehabilitation after injury is a systematic work. Medical staff and caregivers should not only pay attention to neurological function, but also help them improve self-care abilities. It is also important to balance rehabilitation training and school work and social participation.

简介：变形乳癌(MBC)被肿瘤生长，增长和变形前进的联合描绘并且典型地与辩解的目的被管理。标准全身的治疗的利益是相对有限的，疾病被认为医不好建议需要调查变形过程的各种各样的阶段的生物司机以便改进分子地驾驶的治疗的选择。察觉，枚举和传播肿瘤房间(CTC)的分子的分析提供一个吸引人的机会推进这知识。食物和药变清管理的CellSearch系统枚举的CTC在MBC病人是没有前进的幸存(PFS)和全面幸存(OS)的一个独立预示的因素。几份出版报纸为介绍了在血的7.5mL的基础CTC计数5的MBC病人表明了差的预后。因此，CTC的枚举在为MBC的治疗期间向一个工具提供比用常规放射学的测试的解剖评价的标准预定早预言疾病的前进的能力。在词法的变形过程癌症房间展览和phenotypic粘性经历epithelialmesenchymal转变(EMT)期间。这重要现象与被联系在上皮的标记的规定下面(例如，EpCAM)与在当前的CTC丰富方法的适用性的潜在的限制。在很多调查翻译的如此的观察瞄准了改进我们的能力枚举并且表现CTC的分子的描述。理论上，CTC的phenotypic分析能代表能对变形疾病识别一个新潜在的目标并且推进发展并且个性化的治疗监视的胸肿瘤的液体活体检视。