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简介：Thestress-inducedmagneticdomainswitchinginFeGathinfilmsisstudiedusingphase-fieldmethod.Inparticular,themagneticfieldisappliedalongthe[110]directionandbiaxialstressesareappliedalong[100]and[010].Acompressivepre-stresscorrespondstoasmallercoercivemagneticfieldwhileatensilepre-stresscorrespondedtoalargercoercivefield.Atthesametime,itisalsofoundthatthetransitionbetweenbutterflyandsquare-likemagnetostrictionloopsoccursatthecriticaloppositebiaxialstressstate.Thetwodifferentevolutionscorrespondtotwodifferentmechanisms:oneisthatthesingledomainswingsacrossafanareabackandforth;theotheristhatthesingledomainturnsaclockwisecircle.Theresultscanbeexplainedbythestresstunedanisotropyenergywell.

简介：Themicrostructureofstress-inducedmartensite(SIM)inthenanocrystallineNiTialloywasinvestigatedbymeansoftransmissionelectronmicroscopy(TEM).Theresultshowsthatthemulti-variantstructureofthemartensiteissuppressedandonlysingle-variantmartensitictwinsformaftertensiledeformationwhenthegrainsizeissmallerthan80nm.Thenormaldirectionsofthe(001)B190twinplanesareallwithintherangeof45°fromtheaxialdirectionofthewire.Theanglebetweentwincrystals(1'11)Mand(111)ToftheSIMisalsofoundtobesmallerthanthatofthermallyinducedmartensiteinnanocrystallineNiTi.

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简介：目的：讨抑郁症的神经生物学发病机制，揭示针刺治疗抑郁症的机理。方法：以Wistar大鼠为受试对象，采用给予孤养大鼠以长期不可预见的中等强度刺激的方法建立抑郁大鼠模型，检测应激后造成的抑郁模型大鼠行为学改变、下丘脑垂体肾上腺皮质轴（HPA）的变化，同时观察针刺干预效应及不同针法的疗效比较。结果：型组、生理盐水组血清CORT和ACTH含量明显高于正常对照组（P〈0．05）；手针治疗组、电针治疗组血清CORT和ACTH含量明显低于模型组（P〈0．05）；药物组血清CORT和ACTH含量明显低于生理盐水组（P〈0．05）：手针治疗组、电针治疗组、药物组比较差别无统计学意义。结论：刺百会、太冲具有较明显的抗抑郁效应，其机制可能与针刺对HPA轴的调整有关。

简介：Influenceofthermal-mechanicalpropertiesonthefeaturesofthepandapolarization-maintainingopticalfiber(PMF)infabricationprocessisstudiedindetailbyfiniteelementmethod(FEM).Thestressbirefringenceis2.13443×10-4obtainedbythestaticanalysisand2.1269×10-4bydynamicanalysis.Thedifferenceinsimulationbytwomethodsisaround0.4%.Thenon-uniformityofstressbirefringenceinthefibercoreisabout1.6%.Predictedresultsdemonstratethateffectofthethermalconductiveparameteronfiberthermalstressdominates.Thehighanduniformstressbirefringenceinthefibercoreisobtainedbyappropriatelyselectingsuitablestressregionareaandposition.

简介：AbstractPolycystic ovary syndrome (PCOS) is a heterogeneous reproductive disease that can cause infertility. The Hippo signaling pathway, a network highly conserved throughout evolution, maintains the balance between follicle proliferation and dormancy. Dynamic changes in primordial follicles cannot occur without the participation of biological signals and mechanical force; however, little is known about the mechanism by which biomechanical signaling triggers PCOS, especially in the context of primordial follicle development. To investigate the contribution of mechanical stress and the Hippo signaling pathway to the onset of PCOS, we searched the literature via the PubMed database, and inclusion and exclusion criteria were established to ensure the rigor of this research. We eventually included 54 publications in which Hippo signaling and mechanical force were suggested to play a vital role in the development of primordial follicles as well as elucidate the pathogenesis of PCOS. The Hippo pathway modulating follicle growth can be perturbed via extracellular mechanical stress caused by the stiff ovarian cortical environment in PCOS. Clinical intervention targeting the Hippo pathway can alter the activity of core Hippo members, such as the Yes-associated protein/transcriptional co-activator PDZ-binding motif complex. In some patients with PCOS, follicle overactivation can be attributed to the dysfunction of Hippo signal transduction. PCOS, a condition with various patterns, cannot be accurately explained by a single, specific mechanism. The present review identifies potential targets and therapeutic strategies for PCOS.

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简介：它一致地被看了那oncoproteinp28GANK，它是在人的hepatocellular癌(HCC)的overexpressed，在HCC的tumorigenesis起一个关键作用。然而，内在的机制仍然保持不清楚。这里，我们证明p28GANK在endoplasmic蜂窝胃导致的HCC房间禁止apoptosis(嗯)应力。在期间嗯应力，p28GANK提高展开的蛋白质反应，支持嗯从翻译压抑的恢复，并且从而便于房间的能力应付压力条件。而且，p28GANKupregulates调整葡萄糖的蛋白质78(GRP78)，一把钥匙嗯女伴蛋白质，它随后提高合拢能力的ER并且支持恢复从嗯应力。我们也证明p28GANK增加p38激活mitogen的蛋白质kinase和Aktphosphorylation，并且禁止原子因素kappaB(NF-B)激活在下面嗯强调upregulation，它接着贡献GRP78。一起拿，我们的结果显示p28GANK禁止嗯在HCC房间的导致压力的apoptosis，至少部分地，由提高适应反应和GRP78表示。我们建议p28GANK在ER压力条件下面为HCC前进有潜在的含意。

简介：Stressinducedtheseriousdisorderofcardiacfunctionandcardiovasculardiseases.Apoptosisisthecellularbasisinstressinducedcardiacinjury.Inourpreviousstudywefoundthatmanystressorsresultedinmitochondrialdamage.Itiscertainthatmitochondriaisimportantmediatorintriggeringapoptoticcelldeath,butthemechanism,bywhichthestressinducedmitochondrialinjuryleadstocardiomyocyteapoptosis,remainsunclear.Wedesignedthepresentstudytoinvestigatethechangesofthemitochondriaincardiomyocytesundergoingstressanditsroleininducingapoptosis.Herewereportedthatstresschangedthemembranefluidityofmitochondriaandinducedthelipidperoxidationofmitochondrialmembranein

简介：AlthoughrainfallisrareontheLoessPlateauofwesternChina,landslidesoccurfrequentlythereinrainyseason.Surveysreportthatlandslidehazardsalwaysfollowheavyrains.Inthisstudy,aseepage-stresscouplingmodelforrainfallinducedlandslideisusedtoexamineanactualdisastrouseventinYulinbytheendofJuly,2017.Theeffectsofrainfallduration,rainfallintensityandsoilweakeningonslopestabilityarestudiedindetail.Theresultsillustratethatthesafetyfactordropssharplyatfirstandthenisgraduallydecliningtobelow1.05duringadditionaltwodaysofheavyrain.Withsoilstrengthsofteningconsidered,theslopewouldbemoreunstable,inwhichtheweakeninginsoilcohesionisfoundtobeamoresensitivefactor.

简介：Thisarticleanalyzestheverticalstructureoftheonshorecurrentincludingthewave-inducedcurrentbyanequationdevelopedfortheradiationstressagainstwaterdepth.AcoupledmodelCOHERENS-SEDisadoptedtocalculatethewave,tidalcurrent,wave-inducedcurrentandsedimentsimultaneously.ByapplyingthenewmodeltoYangpuBay,itsreliabilityisverified.Thenanidealcoastaldomainisdefinedtosimulatethenearshorecurrentandwavesetupwithnormalincidentwaves.Thenumericalandexperimentalresultsfortheverticalstructureshowtwoundertows,alsoavisiblesetupinthesurfzone.Itdemonstratestheimportanceoftheradiationstressinwave-inducedcurrentsandmeanwaterlevels(set-up/down).

简介：目的methotrexate(MTX)的最重要的副作用是mucositis。这研究的目的是在收到methotrexate的老鼠在肠的损坏和氧化应力上评估沉金摘录的效果。方法实验在划分成六个组的男Wistar白化体老鼠上被执行。首先组织收到的正常盐口头上地，第二个组收到了沉金摘录(100mg瑡潩?????????????????假吗？？

简介：这篇论文扩大放射应力的常规概念(Longuet-Higgins和斯图尔特，1964)在进步的水里向站的波浪招手，以便它的垂直侧面能以一个新技术方法被定义并且计算。水动力学被结合的数字模型在承受波浪的垂直地变化的放射压力被用来模仿被在垂直的节承受波浪导致的水流。推迟的沉积运输的数字建模然后被执行模仿水流由好沉积组成的床的进化。模仿的scour和免职模式在对优先的实验室和地观察的质的同意。

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简介：Principalstressaxesrotationinfluencesthestress-strainbehaviorofsandunderwaveloading.Aconstitutivemodelforsand,whichconsidersprincipalstressorientationandisbasedongeneralizedplasticitytheory,isproposed.Thenewmodel,whichemploysstressinvariantsandadiscretememoryfactorduringreloading,isoriginalbecauseitquantifiesmodelparametersusingexperimentaldata.Foursetsofhollowtorsionexperimentswereconductedtocalibratetheparametersandpredictthecapabilityoftheproposedmodel,whichdescribestheeffectsofprincipalstressorientationonthebehaviorofsand.Theresultsprovetheeffectivenessoftheproposedcalibrationmethod.

简介：Aseriesoftestsofdeformation-inducedferritetransformation(DIFT)inalowcarbonsteelwerecarriedoutbytheGleeble-3500hotsimulationmachineatatemperaturerangeofAe3-Ar3.Theoverallstress-straincurvesduringDIFTcanbedividedintothreetypicaltypes:'double-humped','single-humped'and'transitional'.Thepeaksexhibitedinthecurveareinvolvedwithdeformation-inducedtransformationwhichhappenedingrainsoratthegrainboundaries.Accordingtothestress-timecurveandstrain-timecurve,straincapacitydramaticallypostponedthestrain-inducedtransformation,whichleadstothestartofthetransformationrightaheadofthefinishofdeformationandthemajorityoftheferritetransformationprocessmainlyhappenedafterthedeformation.Deformation-inducedtransformationisametadynamictransformationprocesswithdynamicnucleation.

简介：Thepaperstudiestheproblemoffluidflowandfluidshearstressincanaliculiwhentheosteonissubjecttoexternalmechanicalloadingandbloodpressureoscillation.Thesingleosteonismodeledasasaturatedporoelasticcylinder.Solidskeletonisregardedasaporoelastictransverselyisotropicmaterial.Togetnear-realisticresults,boththeinterstitialfluidandthesolidmatrixareregardedascompressible.BloodpressureoscillationintheHaveriancanalisconsidered.Usingtheporoelasticitytheory,ananalyticalsolutionoftheporefluidpressureisobtained.Assumingthefluidincanaliculiisincompressible,analyticalsolutionsoffluidflowvelocityandfluidshearstresswiththeNavier-Stokesequationsofincompressiblefluidareobtained.Theeffectofvariousparametersonthefluidflowvelocityandfluidshearstressisstudied.更多还原

简介：连续冷却的用法在数字焊接的转变(CCT)图模拟现状。不过，说明在分别地导致不同CCT行为和CCT图的材料的化学作文提供限制。因此，在发展中的剩余压力上在CCT图分析变化的影响是必要的。在现在的纸，在剩余压力的数字计算以后的四张CCT图和他们的效果为煤气的金属弧焊(GMAW)焊接的广泛地使用的结构的钢S355J2+N被调查过程。而非执行CCT行为的任意的调整，四个有理由的数据集合被用作输入到数字计算：在Sysweld数据库，通过Gleebledilatometry测试获得的试验性的数据，和TTT/CCT预言可得到的数据从JMatPro和爱迪生焊接研究所(EWI)计算了虚拟加入门软件。执行数字分析就不同CCT图而言在剩余压力导致了显著偏差。而且，改进失真和剩余的预言的可能性基于CCT强调行为被讨论。

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