简介:AHFreceiverfordatatransmissionbasedonKalmanfilterandchannelestimatorisproposed.Thesimulationresultsshowthattheperformanceoftheproposedschemeisabout2dBbetterthanthatofDecision-FeedbackEqualizerbasedonSquare-RootKalmanAlgorithm(SRKA/DFE)anditscomputationalcomplexityislowerthanthatofMaximumLikelihoodSequenceEstimation(MLSE).
简介:IT产业瞬息万变,每一次技术革新都会带来PC系统性能上的飞跃。CPU的主频已从8088时代飞升到了以GHz为单位的时代,甚至在Intel推出的最新CPU内核——Prescott中,其主频更是高达5GHz这个在以前看来近乎幻想的天文数字。与PC系统整体性能息息相关的内存也告别了EDO、SDRAM时代而进入双通道DDR甚至是DDRU的时代。但在系统硬件不断更新换代的同时,一个不个忽视的瓶颈也制约着整体系统发挥由最高性能,这就是硬盘的数据传输速度。在CPU和内存性能可谓暴涨时,传统的PATA(ParallelATA,并行ATA)接口方式的硬盘却将其传输速度限制在了最高的133MB/s(ATA133)上,显然这已不能满足系统的整体需要,业界也呼唤着硬盘接口方式的一次彻底变革。目前最有希望引领这次变革的,莫过于正在发展壮大中的SerialATA(SATA,串行ATA)了。
简介:InordertoovercometheshortcomingoftheclassicalHungarianalgorithmthatitcanonlysolvetheproblemswherethetotalcostisthesumofthatofeachjob,animprovedHungarianalgorithmisproposedandusedtosolvetheassignmentproblemofserial-parallelsystems.Firstofall,byreplacingparalleljobswithvirtualjobs,theproposedalgorithmconvertstheserial-parallelsystemintoapureserialsystem,wheretheclassicalHungarianalgorithmcanbeusedtogenerateatemporalassignmentplanviaoptimization.Afterwards,theassignmentplanisvalidatedbycheckingwhetherthevirtualjobscanberealizedbyrealjobsthroughlocalsearching.Iftheassignmentplanisnotvalid,theconvertedsystemwillbeadaptedbyadjustingtheparametersofvirtualjobs,andthenbeoptimizedagain.Throughiterativesearching,thevalidoptimalassignmentplancaneventuallybeobtained.Toevaluatetheproposedalgorithm,thevalidoptimalassignmentplanisappliedtolaborallocationofamanufacturingsystemwhichisatypicalserial-parallelsystem.
简介:Thispaperstudiesestimationandserialcorrelationtestofasemiparametricvarying-coefficientpartiallylinearEVmodeloftheformY=Xτβ+Zτα(T)+ε,ξ=X+ηwiththeidentifyingconditionE[(ε,ητ)τ]=0,Cov[(ε,ητ)η]=σ2Ip+1.Theestimatorsofinterestedregressionparametersβ,andthemodelerrorvarianceσ2,aswellasthenonparametriccomponentsα(T),areconstructed.Undersomeregularconditions,weshowthattheestimatorsoftheunknownvectorβandtheunknownparameterσ2arestronglyconsistentandasymptoticallynormalandthattheestimatorofα(T)achievestheoptimalstrongconvergencerateoftheusualnonparametricregression.Basedontheseestimatorsandasymptoticproperties,weproposetheVN,pteststatisticandempiricallog-likelihoodratiostatisticfortestingserialcorrelationinthemodel.Theproposedstatisticsareshowntohaveasymptoticnormalorchi-squaredistributionsunderthenullhypothesisofnoserialcorrelation.Somesimulationstudiesareconductedtoillustratethefinitesampleperformanceoftheproposedtests.
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简介:Objective:Tomonitorthesystemicgeneexpressionprofileinamurinemodeloflipopolysaccharide-inducedacutelunginjury.Methods:Acutelunginjurywasinducedbyintratrachealinjectionoflipopolysaccharidein3mice.Another3normalmicereceivingsamevolumeofnormalsalineweretakenasthecontrols.Thecomprehensivegeneexpressionprofilewasmonitoredbytherecentlymodifiedlongserialanalysisofgeneexpression.Results:Atotalof24670tagsrepresenting12168transcriptsinthecontrolmiceand26378tagsrepresenting13397transcriptsinthemicewithlunginjurywereidentifiedrespectively.Therewere11transcriptsincreasingand7transcriptsdecreasingmorethan10foldsinthelipopolysaccharide-treatedmice.ThemostoverexpressedgenesinthemicewithlunginjuryincludedserumamyloidA3,metallothionein2,lipocalin2,cyclin-dependentkinaseinhibitor1A,lactatedehydrogenase1,melatoninreceptor,S100calcium-bindingproteinA9,natriureticpeptideprecursor,etc.Mitogenactivatedproteinkinase3,serumalbumin,complementcomponent1inhibitor,andATPsynthasewereunderexpressedinthelunginjurymice.Conclusions:Serialanalysisofgeneexpressionprovidesamolecularcharacteristicofacutelunginjury.
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简介:AbstractBackground:Non-communicable chronic diseases have become the leading causes of disease burden worldwide. The trends and burden of "metabolic associated fatty liver disease" (MAFLD) are unknown. We aimed to investigate the cardiovascular and renal burdens in adults with MAFLD and non-alcoholic fatty liver disease (NAFLD).Methods:Nationally representative data were analyzed including data from 19,617 non-pregnant adults aged ≥20 years from the cross-sectional US National Health and Nutrition Examination Survey periods, 1999 to 2002, 2003 to 2006, 2007 to 2010, and 2011 to 2016. MAFLD was defined by the presence of hepatic steatosis plus general overweight/obesity, type 2 diabetes mellitus, or evidence of metabolic dysregulation.Results:The prevalence of MAFLD increased from 28.4% (95% confidence interval 26.3-30.6) in 1999 to 2002 to 35.8% (33.8-37.9) in 2011 to 2016. In 2011 to 2016, among adults with MAFLD, 49.0% (45.8-52.2) had hypertension, 57.8% (55.2-60.4) had dyslipidemia, 26.4% (23.9-28.9) had diabetes mellitus, 88.7% (87.0-80.1) had central obesity, and 18.5% (16.3-20.8) were current smokers. The 10-year cardiovascular risk ranged from 10.5% to 13.1%; 19.7% (17.6-21.9) had chronic kidney diseases (CKDs). Through the four periods, adults with MAFLD showed an increase in obesity; increase in treatment to lower blood pressure (BP), lipids, and hemoglobin A1c; and increase in goal achievements for BP and lipids but not in goal achievement for glycemic control in diabetes mellitus. Patients showed a decreasing 10-year cardiovascular risk over time but no change in the prevalence of CKDs, myocardial infarction, or stroke. Generally, although participants with NAFLD and those with MAFLD had a comparable prevalence of cardiovascular disease and CKD, the prevalence of MAFLD was significantly higher than that of NAFLD.Conclusions:From 1999 to 2016, cardiovascular and renal risks and diseases have become highly prevalent in adults with MAFLD. The absolute cardiorenal burden may be greater for MAFLD than for NAFLD. These data call for early identification and risk stratification of MAFLD and close collaboration between endocrinologists and hepatologists.