简介:AbstractAn increasing body of evidence supports the hypothesis that atherosclerosis is caused by multiple factors and mechanisms. A better understanding of the contribution of hypertriglyceridemia or oleic acid to the pathogenesis of atherosclerosis would significantly increase our ability to successfully treat these diseases. We propose that oleic acid promotes atherosclerosis via multiple pathophysiological mechanisms. Here we suggest that (1) atherosclerosis may develop through multiple pathophysiological mechanisms and that this may be a common feature of human diseases; (2) diseases may be the consequence of natural selection or the interaction of internal and external factors; (3) diseases should be recognized with "biological diversity," and that this concept should be introduced into medical education, clinical treatment, drug research and development, and medical research. The work reported here will benefit a new generation of medical trainees and promote the development of the relevant medical fields.
简介:Objective:Impairedactivefluidtransportofalveolarepitheliummayinvolveinthepathogenesisandresolutionofalveolaredema.Thcobjectiveofthisstudywastoexplorethechangesinalveolarepithelialliquidclearanceduringlungedemafollowingacutelunginjuryinducedbyoleicacid.Methods:Forty-eightWistarratswererandomlydividedintosixgroups,I.e.,injured,amiloride,ouabain,amilorideplusouabainandterbutalinegroups.Twenty-fourhoursaftertheinductionofacutelunginjurybyintravenousoleicacid(0.25ml/kg),5%albuminsolutionwith1.5μCi125Ⅰ-labeledalbumin(5ml/kg)wasdeliveredintobothlungsviatrachea.Alveolarliquidclearance(ALC),extravascularlungwater(EVLW)contentandarterialbloodgasesweremeasuredonehourthereafter.Results:At24haftertheinfusionofoleicacid,theratsdevelopedpulmonaryedemaandseverehypoxemia,withEVLWincreasedby47.9%andALCdecreasedby49.2%.Additionofeither2×10-3Mamilorideor5×10-4MouabaintotheinstillationfurtherreducedALCandincreasedEVLW.ALCincreasedbyapproximately63.7%andEVLWdecreasedby46.9%withimprovedhypoxemiaintheTerbutaline(10-4M)group,comparedthoseininjuredrats.AsignificantnegativecorrelationwasfoundbetweentheincrementofEVLWandthereductionofALC.Onclusions:Activefluidtransportofalveolarepitheliummightplayaroleinthepathogenesisoflungedemainacutelunginjury.
简介:α-Eleostearicacidandβ-eleostearicacidformedvesiclesinaqueousmediumwhenanethanolsolutionofeleostearicacidwasinjectedrapidlyintoavigorouslyvortexedaqueousphase.Formationofthevesicleswasdemonstratedbyelectronmicroscopicobservationandbromothymolblueencapsulationexperiments.PolymerizationsoftheeleostearicacidsintheformedvesiclescarriedoutbyUVirradiationproducedpoly-α-eleostearicacidandpoly-β-eleostearicacidvesicles.
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简介:Acomparisonoftheadsorptionofbenzoicacidandp-nitrobenzoicacidonthenewhypercrosslinkedpolymericadsorbentAM-I,withthatbymacroporousAmberliteXAD-4,includingtheequilibriumadsorptionisotherms,thedynamicadsorptionbehaviorsthroughcolumnandtheadsorptionthermodynamicswerestudied.ResultsshowthatFreundlichequationgivesafittingadsorptionisotherm.ThespecificsurfaceofAM-lisonly67%ofthatofAmberliteXAD-4,buttheadsorptioncapacitiesonAM-1aremuchhigherabout125%~166%thanthatonAmberliteXAD-4,whichiscontributedtothemicroporemechanismandpolarity.Thenegativevaluesoftheadsorptionenthalpyareindicativeofanexothermicprocess.Enthalpyandfreeenergychangesofadsorptionbothmanifestaphysic-sorptionprocess.Thenegativevaluesoftheadsorptionentropyindicatethattheadsorptioniswellconsistentwiththerestrictedmobilitiesandtheconfigurationsoftheadsorbedbenzoicacidmoleculesonthesurfaceofstudiedadsorbentswithsuperficialheterogeneity.Bothadsorbentswereusedinmini-columnexperimentsforadsorbingbenzoicacidexpectingtoelucidatethehigherbreakthroughadsorptioncapacityofthenewhypercrosslinkedpolymericadsorbentAM-1ascomparedwiththatofAmberliteXAD-4.
简介:"Whitepowderytungsticacid"hasbeenusedforpreparingvarioustypesoftungsten-containingcompoundsduetoitshighreactivity.Thepresentpapercoversthestandardmolarenthalpiesofformation,△H0/fofthreetungsten-containingacids.Thevaluesfoundfor"whitepowderytungsticacid"WO3·1.68H2O,"yellowtungsticacid"WO3·1.20H2OanddodecatungstophosphoricacidH3(PW12O40)·25H2Oat298.15Kwere-(1312±1),-(1192±1)and-(18150±13)kJmol-1,respectively.
简介:DisclosedisamethodofpreparinghypophosphorousacidcomprisingcontactinganinsolubleanodewithanaqueoussolutionofhypophosphiteanionsandapplyingadirectcurrentthroughtheinsolubleanodetoacathodeinelectricalcontactwiththeequeoussolutiontogenerateH^+ionsintheaqueoussolutiontherebyformingahypophosphorousacidsolution.Theprocessissimple,lowcostandhighefficient,whichcanbetiedintoanexistingprocessforproducingsodiumhypophosphitewhereintheproductofsodiumhypophosphiteprocessisusedasastartingmaterialinthehypop[hosphorousacidprocess.
简介:AbstractTranexamic acid (TXA) is an anti-fibrinolytic agent which has been proven beneficial in multiple surgical specialties where significant bleeding can occur. Whilst it has been widely available for over 40 years its use within Otorhinolaryngology is still limited. Operations in Otorhinolaryngology are particularly varied with some such as tonsillectomy having the potential for significant life threatening bleeding. Other operations are performed within small confined surgical fields and even small amounts of bleeding can significantly detriment surgical field and increase technical difficulty and operative time. This review evaluated the current literature on the benefits of tranexamic acid within the field of Otorhinolaryngology and Head and Neck Surgery. Overall TXA was demonstrated to be a safe drug with no major adverse effects including thromboembolic events reported in any study. It has been shown to be of particular benefit in rhinology by improving surgical field, reducing operative time and reducing postoperative swelling and ecchymosis. The benefit in tonsillectomy is less clear and further studies are required to evaluate its potential use in the reduction of post tonsillectomy haemorrhage rates.
简介:胆汁酸(BA)由充当tensioactives在肠在胖消化有一个长确定的角色,由于他们的amphipatic特征。BA被肠上皮很高效地重新吸收并且经由大部分被阐明了的运输机制再循环回到肝。BA的运输和合成被特定的血浆膜受体和原子受体紧部分地调整。除了他们的主要效果,BA被宣称在胃肠的癌症,肠的发炎和肠的离子的运输起一个作用。BA不在任何这些生物活动,和结构的要求是相等的通常被识别了。特别地,一些BA可能在煽动性的肠疾病为癌症chemoprevention并且也许是有用的,尽管进一步的研究在这个领域里是必要的。这评论在BA肠的生物学的这些方面盖住最近的开发。
简介:ThermotropicliquidcrystallineVHEterpolyestersmadefromvanillicacid(V),p-hydroxybenzoicacid(H)andpoly(ethyleneterephthalate)(E)werestudiedby400MHzNMRspectra,wideangleX-raydiffraction,scanningelectronandpolarizingmicroscopes.ItwasfoundthattheVHEterpolyestershadrandomsequencedistribution.TheVHEterpolyesterfilmsexhibitedhighlyorientedfibrillarstructure.
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简介:Severalmacroporouspolymericadsorbents(NDA-999,XAD-8,X-5andXAD-2)wereemployedinthestudytoadsorbphenylaceticacidfromaqueoussolution.EffectofsaltandambienttemperatureonadsorptionwasstudiedusingNDA-999adsorbentandtheadsorptionprocessconformstoFreundlich'smodelreasonably.Adsorptiondynamicswereconductedinbatchexperimentsinordertomakeclearthemechanismofadsorptionprocess.Itisprovedthatthesquareddrivingforcemasstransfermodelcanbeadoptedtoelucidatetheprocess.Thetreatmentprocessofindustrialwastewatercontaininghighstrengthofphenylaceticacidwasproposedforcleanerproductionofphenylaceticacid.
简介:AnewtypeofcrystallineantimonicacidSb2O5·3H2Owassynthesized.Thecomposition,crystalstructure,theequilibriumdistributioncoefficientsforsodiumandpotassiumionsandtheion-exchangecapacityofthisexchangerweredetermined.Withthisexchanger,sodiuminoswereremovedfrompotassiumchloride,andthecontentofsodiumchloridewasreducedfrom3.24%to0.02%.Comparedwithotherion-exchangematerials,thecrystallineantimonicacidgivesandunusualselectivityforpotassiumandsodiumions.ThedifferentcompositionsandpropertiesofantimonicacidexchangersareobtainedthroughdifferentpreparingconditionsanditscrystallineformulaofSb2O5·4H2O(C-SbA1)iscurrentlyaccepted.Thispaperreportsanewtypeofcrystallineantimonicacid-Sb2O5·3H2O(C-SbA2),synthesizedbyanimprovedKuzin′smethod.SodiumionsareremovedfrompotassiumchloridewithC-SbA2.TheexchangeefficiencyisbetterthanthatofC-SbA1.