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简介：瞄准：评估intra动脉的5氟尿嘧啶(5-FU)的时间依赖为先进肝细胞癌(aHCC)的治疗。方法：有aHCC和肝肝硬化的37个成年日本病人与联合intra动脉的5-FU，cisplatin(CDDP)，和甲酰四氢叶酸(LV)被对待。每个病人的日本综合阶段分数(JIS分数)是3或更多的。病人被划分成二个组，在组S的15个病人与6-h注入化疗在以后被对待(在12mg/h的LV，在10mg/h的CDDP，并且在250mg/m(2)的5-FU每4h)并且在组L的22个病人与24-h注入化疗(在12mg/h，在10mg/h的CDDP，和在每22h的250mg/m(2)的5-FU的LV)被对待。连续注入化疗经由合适的肝的动脉被执行为用一座植入的药水库的4wk的每5d。结果：有在化疗的4wk以后的部分回答的病人的百分比在组S是6.7%并且31.8%在组L。组L的幸存比组S的显著地好，与是的中部的生存时间在组L的496d和在组S的226d(P<0.05)。结论：连续24-hintra动脉的注入为aHCC是更有效的并且能显著地作为与6-h相比延长生存时间注入。

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简介：客观：由经皮的解压缩和自体同源的骨头marrowmononuclear房间(BMC)评估大腿骨的头的处理ofosteonecrosis的临床的功效和安全注入。方法；在有在早舞台的脉管的坏死的28个病人的44个臀部由解压缩由自体同源的BMCsinfusion跟随了的经皮的多重洞被对待。自体同源的BMC从从病人的以后的肠骨的冠被拿的骨头髓被集中。病人们在至少2年上面被跟随。结果被变化在radiograghic阶段在哈里斯臀部分数和前进决定。结果：Nocomplications在操作以后被观察。在操作前，有在8个臀部，在15个臀部的阶段Ⅱ，在14个臀部的阶段Ⅲ，在7个臀部的阶段Ⅳ，和在最近的后续的手术后的阶段的大腿骨的头坏死的阶段Ⅰ是在1个臀部的阶段O，在6个臀部的阶段Ⅰ，在13个臀部的阶段Ⅱ，在13个臀部的阶段Ⅲ，在7个臀部的阶段Ⅳ，在4个臀部的阶段Ⅴ。吝啬的preoperativeHarris臀部分数是58(46-89)，并且改善了到86(70-94)手术后地。外科手术前地折叠的所有大腿骨的头证明坏死的尺寸是至少超过30%。结论:与自体同源的BMC相结合的经皮的多重洞解压缩是对待大腿骨的头的脉管的坏死的一个新方法。越早阶段，越更好结果。Arandomized未来的学习需要以后与平淡的核心解压缩作比较。

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简介：AbstractBackground:Intravertebral and general anesthesia (GA) are two main anesthesia approaches but both have defects. This study was aimed to evaluate the effect of subarachnoid anesthesia combined with propofol target-controlled infusion (TCI) on blood loss and transfusion for total hip arthroplasty (THA) in elderly patients in comparison with combined spinal-epidural anesthesia (CSEA) or GA.Methods:Totally, 240 patients (aged ≥65 years, American Society of Anesthesiologists [ASA] I-III) scheduled for posterior THA were enrolled from September 1st, 2017 to March 1st, 2018. All cases were randomly divided into three groups to receive CSEA (group C, n = 80), GA (group G, n = 80), or subarachnoid anesthesia and propofol TCI (group T, n= 80), respectively. Primary outcomes measured were intra-operative blood loss, autologous and allogeneic blood transfusion, mean arterial pressure at different time points, length of stay in post-anesthesia care unit (PACU), length of hospital stay, and patient satisfaction degree. Furthermore, post-operative pain scores and complications were also observed. The difference of quantitative index between groups were analyzed by one-way analysis of variance, repeated measurement generalized linear model, Student-Newman-Keuls test or rank-sum test, while ratio index was analyzed by Chi-square test or Fisher exact test.Results:Basic characteristics were comparable among the three groups. Intra-operative blood loss in group T (331.53 ± 64.33 mL) and group G (308.03 ± 64.90 mL) were significantly less than group C (455.40 ± 120.48 mL, F = 65.80, P < 0.001). Similarly, the autologous transfusion of group T (130.99 ± 30.36 mL) and group G (124.09 ± 24.34 mL) were also markedly less than group C (178.31 ± 48.68 mL, F= 52.99, P < 0.001). The allogenetic blood transfusion of group C (0 [0, 100.00]) was also significantly larger than group T (0) and group G (0) (Z = 2.47, P = 0.047). Except for the baseline, there were significant differences in mean arterial blood pressures before operation (F= 496.84, P < 0.001), 10-min after the beginning of operation (F = 351.43, P < 0.001), 30-min after the beginning of operation (F = 559.89, P < 0.001), 50-min after the beginning of operation (F = 374.74, P < 0.001), and at the end of operation (F= 26.14, P < 0.001) among the three groups. Length of stay in PACU of group T (9.41 ± 1.19 min) was comparable with group C (8.83 ± 1.26 min), and both were significantly shorter than group G (16.55 ± 3.10 min, F = 352.50, P < 0.001). There were no significant differences among the three groups in terms of length of hospitalization and post-operative visual analog scale scores. Patient satisfaction degree of group T (77/80) was significantly higher than group C (66/80, χ2= 7.96, P = 0.004) and G (69/80, χ2 = 5.01, P = 0.025). One patient complained of post-dural puncture headache and two complained of low back pain in group C, while none in group T. Incidence of post-operative nausea and vomiting in group G (10/80) was significantly higher than group T (3/80, χ2 = 4.10, P = 0.043) and group C (2/80, χ2 = 5.76, P = 0.016). No deep vein thrombosis or delayed post-operative functional exercise was detected.Conclusions:Single subarachnoid anesthesia combined with propofol TCI seems to perform better than CSEA and GA for posterior THA in elderly patients, with less blood loss and peri-operative transfusion, higher patient satisfaction degree and fewer complications.

简介：Non-small-celllungcancer(NSCLC)accountforapproximately80%ofalllungcancer.Onlyalowpercentageofpatientspresentdiseasesusceptibletosurgicalresection.30%to40%ofpatientswithNSCLCpresentwithlocallyorregionallyadvancedunresectabletumors.lllChestirradiationp...

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