简介：Atrialfibrillation(AF),themostcommonlyencoun-teredarrhythmiainclinicalpractice,isassociatedwitha2-foldincreaseintotalcardiovascularmortality[1],aswellasthepotentialforsubstantialmorbidity,includingstroke,congestiveheartfailure,andcardiomyopathy.Itsincidenceandprevalenceareincreasing,anditrepresentsagrowingclinicalandeconomicburden.Owingtorela-tiveinefficacyandside

简介：BackgroundHypertensionassociatedwithhyperhomocysteinemia(HHcy)isdefinedasH-typehypertension.HypertensionandHHcyhasastrongsynergythatcouldleadtotheriskofvasculardisease,suchascarotidremodeling.However,therelationofinflammatoryfactorsandadhesionmoleculewithcarotidremodelinginH-typehypertensionisunknown.MethodsFifty-sixpatientswithH-typehypertensionand52withouthyperhomocysteinemiahypertensionwereenrolledinthisstudy,with42healthyvolunteersasthecontrolgroup.AllthesubjectsunderwentcolorDopplerultrasoundexaminationofcarotidartery.TheexpressionofICAM-1inperipheralbloodmonocyteswasmeasuredbydirectimmunofluorescencetechniqueincombinationwithflowcytometry.ThelevelsofhighsensitivityC-reactiveprotein(hs-CRP),Monocytechemoattractantprotein-1(MCP-1)andsICAM-1weremeasured.Thecorrelationsbetweencarotidvascularremodelingandthesebiomarkerswereanalyzed.ResultsTheintima-mediathickness(IMT),circulatinglevelsofhs-CRPandMCP-1,andmonocyteICAM-1weresignificantlyincreasedinH-typehypertensiongroup(P<0.05).Therewerenosignificantdifferenceinthosemeasurementsbetweenthesimplehypertensiongroupandthecontrolgroup(P>0.05).ThelevelsofsICAM-1showednosignificanceamongthethreegroups(P>0.05).Correlationanalysesrevealedapositivecorrelationofcarotidplaqueindexwithhomocysteine,hs-CRPandMCP-1,andtheexpressionofICAM-1inthemonocytesintheH-typehypertensiongroup.MultivariatelogisticregressionanalysisrevealedthatHcyandhs-CRPweretheindependentriskfactorsofIMTintheH-typehypertensiongroup.ConclusionThepatientswithH-typehypertensionaremorelikelytohavecarotidvascularremodelingwithhigherlevelsofinflammationandadhesionmoleculeswhichmightleadtothedevelopmentofatherosclerosis.

简介：ObjectivesToinvestigatetheeffectofsimvastatinontheprobabilityofrestenosisafterstentimplantationandserumleveloflipidsaswellashigh-sensitivityC-reactiveprotein(hs-CRP)inpatientswithcoronaryheartdisease(CHD).Methods118patientswithCHDafterstentingtherapyweredividedintotreatmentgroup(n=62)andcontrolgroup(n=56)randomly.Allpatientsweretreatedwithaspirin(100mg/d)andclopidogrel(75mg/d)whiletreatmentgrouppatientstooksimvastatin(40mgqn)additionally.Allpatientsunderwentcoronaryangiography(CAG)tocomparethedifferenceofrestenosisandtheserumleveloftotalcholesterol(TC),low-densitylipoproteincholesterol(LDL-c),high-densitylipoproteincholesterol(HDL-c),triglyceride(TG)aswellashs-CRPafterthedrugtreatmentfor6months.ResultsTheprobabilityofrestenosiswassignificantlylowerinthetreatmentgroupthanthatofcontrolgroup(P<0.01)andtheresultsweresimilarbetweenthepatientswithbaremetalstent(P<0.01)andthosewithsirolimus-elutingstent(P<0.01).TheserumlevelsofTC(P<0.01),LDL-c(P<0.01),TG(P<0.05)andhs-CRP(P<0.01)wereobviouslylowerwhiletheHDL-c(P<0.05)levelwashigherinthetreatmentgroupthanthoseofcontrolgroup.Therewasnodeathcase.ConclusionsSimvastatincoulddecreasetheprobabilityofrestenosissignificantlyaftercoronarystentimplantationwithdoseof40mg/d.Italsohasgoodperformanceonlipidscontrolandlighteninginflammatoryreactionswithitsundoubtedlysafety.