简介:AbstractChronic hepatitis B virus (HBV) infection remains a global health burden. Timely and effective antiviral therapy is beneficial for patients with HBV infection. With existing antiviral drugs, including nucleos(t)ide analogs and interferon-alfa, patients can achieve viral suppression with improved prognosis. However, the rate of hepatitis B surface antigen loss is low. To achieve a functional cure and even complete cure in chronic hepatitis B patients, new antivirals need to be developed. In this review, we summarized the advantages and disadvantages of existing antiviral drugs and focused on new antivirals including direct-acting antiviral drugs and immunotherapeutic approaches.
简介:<正>WeareexcitedtoreleasethefirstissueofHighPowerLaserScienceandEngineering(abbreviatedHPLaser)atthebeginningof2013,YearoftheSnakeintheChinesecalendar.Firstofall,Iwouldliketogiveoursincerethankstothosewhohavecontributedtothepublishingofthenewjournal.Sincetheinventionoflaserin1960,therequirementsofscientificresearchhavedriventhedevelopmentofhighpowerlasertechnology.Laseroutputpowercontinuestoincreasedramaticallythroughthedevelopmentoflasertechnology,andmanynewresearchtopicsarebeingdiscoveredandcreated.
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简介:Inthe60yearssincethefoundingofthePeople'sRepublicofChina,thecountryhaspursuedapeace-orientedforeignpolicy.AftertheendoftheBeijingOlympicsinOctober2008,China'sforeignrelationsbegantotakeonanewlook.Thecountrynowparticipatesmoreactivelyinglobalandregionalissues,forgingmultilateralandbilateralrelationships,andenteringintodiscussionsonmaritimerightsandmilitarystrategy.ItcouldbesaidthatChinaisnowshowingmoreinitiative,independence,confidence,transparencyandagreatersenseofresponsibility,andstrengtheningcooperationwithallpartners.ThesechangesaremainlyduetoChina'sincreasingcomprehensivenationalstrengthanditsneedtointegrateintotheinternationalsysteminapeacefulandharmoniousmannerwithbenefitstoall.Chinahasredefineditsidentityandreassesseditsinterests.Thesechangesareongoing,andthenation'sdiplomacyisstillnotperfect,butthegeneraldirectionhasnowbeenset.
简介:ForthoseofyouhaveseenUp(《飞屋环游记》),youmayrecall78-yearoldCarlandeight-yearoldRussell,whoflewoffinahouseliftedbyheliumballoons.Now,anAmericanmanhasaccomplishedasimilarjourney..However,insteadofflyingthousandsofmilesinsideahouse,hesatinachairand"flew"22miles,acrosstheEnglishChannel.