简介：AbstractVitiligo, a common skin depigmentation disorder, is the result of complex interactions of genetic, immunological, environmental, and biochemical events. Treatments for vitiligo include drugs, phototherapy, surgical transplantation, and so on. Among them, the efficacy of narrow band-ultraviolet B has been confirmed. By inducing keratinocyte-derived factors and signalings, narrow band-ultraviolet B can trigger and/or promote the mobilization of melanocytes which migrate to lesional epidermis ultimately, leads to the repigmentation of white patches. The mobilization of melanocytes includes stages of activation, migration, proliferation, and differentiation. Elucidating processes that enable the specific mobilization of melanocytes and the signaling pathways and factors involved, will help the development of new drugs and methods for the treatment of vitiligo.

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简介：Citricandmalicacidsatconcentrationsof0.1,1.0,10,and100mmol/LwereaddedtothreeUltisolsandoneOxisol,TheamountofPinsolutionincreasedwithincreasingorganicacidconcentrations,whiletheamountofFe-andAl-boundPdecreased.ThisresultsuggestedthatnaturallyoccurringproductsoforganicmatterdecompositioncouldincreasethePavailabilitytoplantsinsoilswherethereisarelativelylargepoolofFe-andAl-boundP.Theinteractionsbetweencitricandmalicacidsattheaboveconcentrations,andpaddedatratesof10,20,40,and80mg/kgweredetermined.Atzerolevelsoforganicacids,alladdedPbecameeitherlabileorbound,andgreaterproportionsremainedsolubleastheconcentrationoforgaicacidsincreased,whichsuggestedthatorganicacidsreducedfixationofdissolvedPinFe-andAL-richsoils.AgriculturalpracticeswhichincreaseorganicmatterinputonP-deficientacidsoildcoulddecreasePdeficiency,Thiswouldbeimportantinmanytropicalandsubtropicalregionswherethesesoilsarecommon,andwherethecostsoffertilizersandlimearerelativelyhigh.

简介：TherearetwomaintypesofirondepositsintheMiddle-LowerYangtzeValleydistrict.Bothofthemunderwentpost-magmatichydrothermalprocessesduringoreformation.Ironinthehydrothermalorebodieswasderivedlargelythroughmobilizationfromsubstantiallyconsolidateddiroiticintrusives.Wall-rochalterationzonationindicatesthatiron-mobilizinghydrothermalfluidsevolvedinatrendofdecreasingalkalinity,whichissuggestedbyregularlydistributedwall-rockalterationsformedbyiron-mobilizinghydrothermalfluidsandisincontradictionwiththecurrentchloride,chloridecomplexandbicarbonatemodelsforironmobilization.ThecloseassociationofcarbonatizationwithironoresandthehighconcentrationsofreducedgasessuchasCO,CH4andH2influidinclusionssuggestthatironismostprobablytransportedintheformofironcarbonylsduringpost-magmatichydrothermalprocesses.Inthelightoftheironcarbonylmobilizationmodel,explanationsaremadeoftheconstraintsonoresofsomegeologicfactorssuchasmelanocraticalteration,carbonatization,carbonatestrata,structuralfractures,cyptoexplosivepipesandembryoores.

简介：Thetypicalblackstormsorsand-duststormsinthenorthwesternChinaaregeneratedanddevelopedthroughaninteractionbetweenthespecificlargescalecirculationpatternandmesosealesystems.Thepassingby/overahugesand-abundantdesertofastrongcoldfrontwithintensivefrontalzoneatmidandlowerlevelsisanecessaryconditionfortheformationanddevelopmentofablackstormoraseveresand-duststorm.Inordertoinvestigatethemechanismofthesand-dustmobilization,transportandsedimentationduringtheblackorsand-duststorms,aparameterizationschemeofsand-dustsource-sinktermsandanequationoftransportforthesand-dustwereproposedandincorporatedintotheMM4mesoscalemodel.ThemodifiedMM4modelwasappliedtothe“May1993”blackstormcaseandsucceededinreproducingtheevolutionoftheweathersystemsassociatedwiththeblack-storm,thesand-dustconcentrationatsurfacelayeranditsverticaldistribution,andthesand-dustsedimentationandtransport.Ourresultsshowthatthenumericalsimulatingmethodbyusingamesoscalemodel,withinclusionofanequationofthesand-dusttransportandaparameterizationschemeofthesand-dustsource-sinkterms,isapromisingapproachtostudythemechanismforsand-dustmobilization,transportandsedimentationduringasand-duststormevent.

简介：Myeloidsarcoma(MS)isararehematologicalneoplasmthatdevelopseitherdenovoorconcurrentlywithacutemyeloidleukemia(AML).ThisneoplasmcanalsobeaninitialmanifestationofrelapseinapreviouslytreatedAMLthatisinremission.A44-year-oldmalepatientwasdiagnosedwithtestisMSinalocalhospitalinAugust2010.Afteronemonth,bonemarrowbiopsyandaspirationconfirmedthediagnosisofAML.Allogeneicmobilizationperipheralbloodstemcelltransplantationwasperformed,withthesisterofthepatientasdonor,aftercompleteremission(CR)wasachievedbychemotherapy.Fivemonthsaftertreatment,anadrenalmasswasdetectedbypositronemissiontomography-computedtomography(PET-CT).Radiotherapywasperformedforthelocalizedmassafteramultidisciplinaryteam(MDT)discussion.ThepatientisstillaliveasofMay2013,withnoevidenceofrecurrentMSorleukemia.

简介：AbstractBackground:Chemotherapy plus granulocyte colony-stimulating factor (GCSF) regimen is one of the available approaches to mobilize peripheral blood progenitor cells (PBPCs). It causes thrombocytopenia and delays leukapheresis. This study aimed to evaluate the role of recombinant human thrombopoietin (rhTPO) before mobilization chemotherapy in facilitating leukapheresis in patients with lymphoma.Methods:In this randomized open-label phase 2 trial, patients were randomly assigned in a 1:2 ratio to receive mobilization with rhTPO plus GCSF in combination with chemotherapy (the rhTPO plus GCSF arm) or GCSF alone in combination with chemotherapy (the GCSF alone arm). The recovery of neutrophils and platelets and the amount of platelet transfusion were monitored.Results:Thirty patients were enrolled in this study between March 2016 and August 2018. Patients in the rhTPO plus GCSF arm (n = 10) had similar platelet nadir after mobilization chemotherapy (P=0.878) and similar amount of platelet transfusion (median 0 vs. 1 unit, P=0.735) when compared with the GCSF alone arm (n = 20). On the day of leukapheresis, the median platelet count was 86 × 109/L (range 18-219) among patients who received rhTPO and 73 × 109/L (range 42-197) among those who received GCSF alone (P=0.982). After the use of rhTPO, the incidence of platelet count <75 × 109/L on the day of leukapheresis did not decrease significantly (30.0% vs. 50.0%, P=0.297). Platelet recovery after PBPC transfusion was more rapid in the rhTPO plus GCSF arm (median 8.0 days [95% confidence interval 2.9-13.1] to platelets ≥50 × 109/L vs. 11.0 days [95% confidence interval 8.6-13.4], P=0.011). The estimated total cost of the mobilization and reconstitution phases per patient was similar between the two treatmtent groups (P=0.362 and P=0.067, respectively).Conclusions:Our findings indicate that there was no significant clinical benefit of rhTPO use in facilitating mobilization of progenitor cells, but it may promote platelet recovery in the reconstitution phase after high-dose therapy.Trial registration:This trial has been registered in Clinicaltrials.gov as NCT03014102.

简介：Pressuresolutionisacommonphenomenoninmassivesulphidezinc-leaddepositsofwesternCanadaandmayhavebeenanimportantfactorleadingtothemobilizationofore-formingmaterialsduringdiagenesis,deformationandmetamorphismofsedimentaryores.Thecontrolofductileshearzonesovergoldmineralizationcouldbeexplainedinviewofpressuresolutionofgold-bearingminer-alsundershearingstressandthetesultantmobilizationofthismetal.

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简介：论战的AT1受体自身抗体(AT1-AAs)与恶意的高血压或preeclampia在病人被描述了。而且，AT1-AAs高度与倔强的高血压被联系。脉管的光滑的肌肉房间(VSMC)的功能在血压的规定是重要的。我们调查了并且比较了血管收缩素II(AngII)和AT1-AAs的能力刺激细胞内部的钙动员和老鼠VSMC的细胞的增长。有倔强的高血压，有非倔强的高血压的24个病人和37normotensives的22个病人被招募。每个病人的浆液被ELISA为AT1-AAs的存在检测。从病人的sera的AngII和AT1-AAs被用来在vitro刺激老鼠VSMC。AT1-AAs分别地与倔强的高血压，非倔强的高血压和normotensives在病人的10/22，3/24和3/37被检测。AT1-AAs带了增加以一种剂量依赖者方式和VSMC的细胞的增长的细胞内部的钙动员就作为AngII。AT1-AAs引起的这两效果与losartan或相应于AT1受体的第二个细胞外的环的部分的肽被堵住。因为AT1-AAs就作为AngII在老鼠VSMC展出了药理学活动，他们可能在外部脉管的抵抗的举起并且在脉管的改变起一个作用。并且AT1-AAs被建议在抵抗包含到antihypertensive治疗。