简介:ThispaperreportsthephotochemicaldegradationofMethyleneBlue(MB)innaturalseawater(NSW).Thephotode-gradationreactionconformedtothefirst-orderreactionkineticswiththerateconstant0.0158min-1.MBwasphotochemicallyde-gradatedfasterunderhigh-pressuremercurylamp(HPML)thanundersunlight.WhenMBwasinlowerconcentrations,salinitycouldinhibitthephotoreactionwhereasMBinhigherconcentration,salinitycouldacceleratethephotoreaction.Humidacidcouldalsoinhibitthephotoreactions.ToxicitytestswithmarinephytoplanktonSkeletonemacostatum(Sk)andHeterosigmaakashiwoHada(Ha)showeddecreasedacutetoxicityafterphotodegradation.
简介:在这研究,我们在温和碱的条件下面与极佳的吸附性质为hydrogels的准备选了玉米stover为hemicellulose。克莱nanosheets被介绍给这个系统,hemicellulose/clay混血儿hydrogels被准备。词法、机械性质和准备hydrogels的甲又蓝色吸附行为被学习。结果建议泥土的增加不仅改进了基于hemicellulose的hydrogels的机械力量,而且在甲又蓝色上增加了吸附能力。而且,吸附被证实有或没有泥土为两胶化跟随伪秒顺序方程。为基于hemicellulose的hydrogels与或没有泥土的甲又蓝色上的最大的吸附能力分别地到达了148.8和95.6mg/g。这些结果暗示基于hemicellulose的hydrogels能从浪费水为甲又蓝色的移动被用作有希望的吸附物。
简介:Sm(Ⅲ)wasquantitativelyadsorbedbyaminomethylenephosphonicacidresin(APAR)inthemediumofpH=5.0,Thestaticallysaturatedsorptioncapacityis251mg/g.resin.Sm(Ⅲ)adsorbedonAPARcanbereductivelyelutedby2.0mol/LHCl.Thesorptionrateconstantisk298=1.35×10^-5s^-1.ThesorptionbehaviorofAPARforSm(Ⅲ)obeystheFreundlichisotherm.TheenthalpychangeΔH°ofsorptionis24.9kJ/mol.TheapparentactivationenergyisEa=11.7kJ/mol.ThesorptionmechanismshowsthatthenitrogenandoxygenatomsofthefunctionalgroupofAPARcoordinatedwithSm(Ⅲ)toformcoordinationbond.
简介:Anewkindofmonomerswassuccessfullysynthesizedbythereactionbetween2-chloromethylcycloketalandtrimethylsilylcyanide,followedbyringclosureanddehaiogenation.Polymerizationsofthemonomerswerecarriedoutinbenzenesolutionat80℃withbenzoylperoxideasinitiator.BoththestructuresofmonomersandpolymerswerecharacterizedbyIR,1HNMR,13CNMRandelementalanalysis.
简介:Palladium-catalyzedallylationofcarbonucleophileshasbeenwidelyusedforcarbon-carbonbondformation.Amongtheallyliccompoundsstudied,allylicacetatesweremostwidelyusedasprecursorsof(π-allyl)palladiumintermediates.However,basessuchasNaHmustbeusedtogenerateanionsinthisreaction.Recently,researchoncarryingoutthepalla-
简介:Inamixedsolventofaceticacid(AcOH)/water,methylenediphenyldicarbamate(MDC)wassynthesizedbythecondensationofmethylphenylcarbamate(MPC)andformaldehydeinthepresenceofaninorganicacidcatalyst.BasedonthedifferentsolubilitiestoMPCandMDC,themixedsolventshowedhighercatalyticperformancethanpurewater.ThemixedsolventnotonlypromotedthecondensationofMPCbutasloexhibitedtheadvantageoftheproductseparationwiththereactants.Undertheoptimizedconditions:aH_2SO_4massfractionof31%,areactiontemperatureof95℃andreactiontimeof3.5h,theyieldofMDCreached74.3%.Inaddition,therecycleofthesolventwasalsoinvestigated.
简介:Adirect-currentairplasmajetoperatedunderwaterpresentsthreestablemodesincludinganintermittently-pulseddischarge,aperiodically-pulseddischargeandacontinuousdischargewithincreasingthepowervoltage.Thethreedischargemodeshavedifferentappearancesfortheplasmaplumes.Moreover,gapvoltage-currentcharacteristicsindicatethatthecontinuousdischargeisinanormalglowregime.Spectrallinesfromreactivespecies(OH,N_2,N_2~+,H_α,andO)havebeenrevealedintheemissionspectrumoftheplasmajetoperatedunderwater.SpectralintensitiesemittedfromOHradicalandoxygenatomincreasewithincreasingthepowervoltageorthegasflowrate,indicatingthatreactivespeciesareabundant.Thesereactivespeciescausethedegradationofthemethylenebluedyeinsolution.Effectsoftheexperimentalparameterssuchasthepowervoltage,thegasflowrateandthetreatmenttimeareinvestigatedonthedegradationefficiency.Resultsindicatethatthedegradationefficiencyincreaseswithincreasingthepowervoltage,thegasflowrateorthetreatmenttime.Comparedwithdegradationintheintermittently-pulsedmodeortheperiodically-pulsedone,itismoreefficientinthecontinuousmode,reaching98%after21mintreatment.
简介:ThehighlyorderedTiO2nanotubes(NTs)werefabricatedbytheanodicoxidationmethod.Theirmorphology,structureandcrystallinephasewerecharacterizedbyscanningelectronmicroscopy(SEM)andX-raydiffractometer(XRD).Theeffectsofmorphology,specificsurfacearea,porestructuresandphotocatalyticactivityoftheTiO2NTswereinvestigated.UV–visspectraanalysisshowedthatitslightabsorptionhadbeenextendedtothevisiblelightrange.Thephotocatalyticactivityoftheas-preparedsampleswasevaluatedbyphotocatalyticoxidationofgaseousHCHOandMBaqueoussolution.Thesampleshadbetteradhesionstrengthinthedarkandshowedahigherphotocatalyticactivitythannanoparticles.Especially,withultravioletlightpretreatment,thenanotubesexhibitedmorestableactiveforphotocatalyticdecompositionandthephotodecompositionrateremainedathighlevelafter3cyclesofthephotocatalysisexperiment.Thus,howthenumberofsurfaceactivegroup·OHincreasedandthemechanismforthegreatimprovementforthephotocatalyticactivityarediscussed.
简介:AbstractBackground:Methylene blue is the most commonly used tracer for sentinel lymph node (SLN) biopsy (SLNB) in China. This study aimed to investigate the feasibility of clinical application of SLNB using methylene blue dye (MBD) for early breast cancer and the prognosis of patients with different SLN and non-SLN statuses.Methods:We retrospectively analyzed the clinicopathological data of patients with early breast cancer treated at the Peking University First Hospital between 2013 and 2018. We calculated the SLN identification rate (IR) in SLNB with MBD and the false-negative rate (FNR), and analyzed the prognosis of patients with different SLN and non-SLN statuses using Kaplan-Meier curves.Results:Between January 2013 and December 2018, 1603 patients with early breast cancer underwent SLNB with MBD. The SLN IR was 95.8% (1536/1603). Two SLNs (median) were detected per patient. There were significant differences in FNR between patients with SLN micrometastasis and macrometastasis (19.0% vs. 4.5%, χ2 = 12.771, P < 0.001). Chi-square test showed that there were significant differences in SLN successful detection rates among patients with different vascular tumor embolism status (96.3% vs. 90.8%, χ2 = 9.013, P = 0.003) and tumor (T) stages (96.6% vs. 94.1%, χ2 = 5.189, P = 0.023). Multivariate analysis showed that vascular tumor embolism was the only independent factor for SLN successful detection (odds ratio: 0.440, 95% confidence interval: 0.224-0.862, P = 0.017). Survival analysis showed a significant difference in disease-free survival (DFS) between patients with non-SLN metastasis and patients without non-SLN metastasis (P = 0.006).Conclusion:Our single-center data show that, as a commonly used tracer in SLNB in China, MBD has an acceptable SLN IR and a low FNR in frozen sections. This finding is consistent with reports of dual tracer-guided SLNB. Positive SLNs with non-SLN metastasis are associated with DFS.
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简介:AbstractBackground:Clinical observational studies revealed that 99Tc-methylene diphosphonate (99Tc-MDP) could reduce joint pain and swollenness in rheumatoid arthritis (RA) patients. This multicenter, randomized, double-blind, double-dummy study aimed to evaluate the effects of 99Tc-MDP plus methotrexate (MTX) vs. MTX alone or 99Tc-MDP alone on disease activity and structural damage in MTX-naïve Chinese patients with moderate to severe RA.Methods:Eligible patients with moderate to severely active RA were randomized to receive 99Tc-MDP plus MTX (n = 59) vs. MTX (n = 59) alone or 99Tc-MDP (n = 59) alone for 48 weeks from six study sites across four provinces in China. The primary outcomes were the American College of Rheumatology 20% improvement (ACR20) response rates at week 24 and changes in modified total Sharp score at week 48.Results:At week 24, the proportion of participants achieving ACR20 was significantly higher in the MTX+ 99Tc-MDP combination group (69.5%) than that in the MTX group (50.8%) or 99Tc-MDP group (47.5%) (P = 0.03 for MTX+ 99Tc-MDP vs. MTX, and MTX+ 99Tc-MDP vs.99Tc-MDP, respectively). The participants in the MTX+ 99Tc-MDP group and the 99Tc-MDP group had significantly less important radiographic progression than the participants in the MTX group over the 48 weeks (MTX + 99Tc-MDP vs. MTX: P = 0.03, 99Tc-MDP vs. MTX: P = 0.03, respectively). There was no significant difference in terms of adverse events (AEs) among the groups. No serious AEs were observed.Conclusions:This study demonstrated that the combination of 99Tc-MDP with MTX inhibited structural damage and improved disease activity in RA patients compared with MTX and 99Tc-MDP monotherapies, without increasing the rate of AEs. Additional clinical studies of 99Tc-MDP therapy in patients with RA are warranted.Trial Registration:Chictr.org, ChiCTR-IPR-14005684; http://www.chictr.org.cn/showproj.aspx?proj=10088.