简介：在心肌层的重入的推动被认为是支持electrophysiological畸形或甚至导致室的心悸亢进(vt)和室的纤维性颤动(VF)的一个主要因素。重入的波浪的尖端轨道能反映重入的运动的电的繁殖和区域的稳定性，从而在在VT/VF期间学习电的活动被看作大多数担心的参数之一。现在的学习的目的是建议一个实际方法用一条计算途径发现尖端轨道。在室的房间的这个学习Luo-Rudy1991数学模型被使用。切开方法的操作员被利用在二维的织物集成部分微分方程。并且螺线波浪被切割波浪前面技术开始。通过我们发现了它的实验是困难的由发现在大多数报纸求婚了的二根isovoltage线的交叉发现尖端。因此，我们建议尖端点被寻求二根邻近的isovoltage轮廓线的最短的距离检测。结果证明以我们的方法发现的这些螺线波浪的尖端轨道很接近观察的尖端，暗示我们在测量在心脏的再废的尖端轨道的方法的确认。

简介：AbstractImportance:Several methods have been established in recent decades that allow use of spot urine to estimate dietary sodium intake. However, their accuracies have been controversial in children.Objective:To validate the performance of three commonly used methods—the Kawasaki, Tanaka, and International Cooperative Study on Salt, Other Factors, and Blood Pressure (INTERSALT) methods. Additionally, this study explored the accuracies of the Tanaka and INTERSALT methods by using spot urine samples taken at four separate times.Method:Forty-one adolescents aged 14 to 16 years completed two non-consecutive 24-hour urine collections and their mean values were used as reference data. The second-morning urine was used for assessment with the Kawasaki method; a casual spot urine and spot urine samples taken at four separate times (morning, afternoon, evening, and overnight) were used for assessment with the Tanaka and INTERSALT methods.Results:The mean differences were 1801 mg, 542 mg, 47 mg, and -31 mg for the Kawasaki, Tanaka, INTERSALT1 (with potassium), and INTERSALT2 (without potassium) methods with their required spot urine, respectively. The proportions of relative difference levels within ± 10% were 4.9% for the Kawasaki method, 19.5% for the Tanaka method, 36.6% for the INTERSALT1 method, and 36.6% for the INTERSALT2 method.Interpretation:The INTERSALT method seemed to provide minimally biased estimations of mean population sodium intake with casual spot urine. However, there is a need to be cautious regarding inconsistencies in estimation among different levels of sodium intake. The methods assessed in this study were unable to accurately estimate sodium intake at the individual level.

简介：Traditionally,bonestructureandbonemassareassessedbyobservingtherari-fiedboneonstandardx-rayfilms.However,smallchangesinbonemasscannotbedetectedeffectively.Bythetimelossofbonemasscanbedetectedonthex-ray,thediseaseisalreadyinanadvancestage.Atleast30%ofbonemustbelostbeforeproblemslikeosteoporosiscanbediagnosed.

简介：Objective:Tomeasuremovementsofmarkersovertheprimarysiteandassociatedmimicmusclesincertainfacialexpressions,forevaluatingfacialparesisandsynkinesis.Methods:Participantsincluded22normalsubjectsaged45e66years.Maximumshift(Smax)andvelocity(Vmax)weremeasuredusingacustom-designed3-Ddynamicquantitativeanalysissystemoffacialmotion(3-DASFM)basedonmotioncapturetechnology.Measuresweretakenfromperi-oralmusclesduringforcefulbrowraisingandtighteyeclosure,andfrommusclesaroundtheeyeduringgrinning,right/left/bilateralmouthcornerraisingandsmiling.Results:1)Duringforcefulbrowraising,Smaxwas3.65e4.46mmformarkersoverperioralmuscles,withthemarkeroverthenasolabialfoldshowingaVmaxgreaterthanothers(60.60mm/sonleftand62.70mm/sonright).2)Intighteyeclosure,Smaxofperioralmusclemarkerswas1.58e1.92mm,withVmaxbeing11.40e14.76mm/s.3)Ingrinning,thelargesteyemusclemarkerSmaxwasseenatthelowerlid(3.93mmonleftand4.15mmonright)andthesmallestattheinnercanthus(1.59mmonleftand1.53mmonright),withthelargestVmaxseenattheupperlidandsmallestalsoattheinnercanthus(11.71mm/sonleftand11.09mm/sonright).4)Insmiling,thelargestnon-oralSmaxandVmaxwereseenattheupperlid(3.05mmand36.14mm/sonleftand2.53mmand28.90mm/sonright)andthesmallestalsoattheinnercanthus(0.69mmand7.22mm/sonleftand0.77mmand7.80mm/sonright).5)Inrightmouthcornerraising,SmaxandVmaxatlateralandmedialcanthusandatlowerlidweregreateronrightthanleft,whilethoseatupperlidandbrowwereslightlygreateronleftthanright.6)Inleftmouthcornerraising,SmaxandVmaxatlateralcanthusandupperandlowerlidsweregreateronleftthanright.Conclusions:Therearenoabsoluteimmobilepointsonthefacewhenmakingfacialexpressions.Inadditiontotheprimarymovementsite,thereareassociatedmovementsatotherpointsonthefacewithconsistent

简介：Althoughstimulusfrequencyotoacousticemissions(SFOAEs)havebeenusedasanon-invasivemeasureofcochlearmechanics,clinicalandexperimentalapplicationofSFOAEshasbeenlimitedbydifficultiesinaccuratelyderivingquantitativeinformationfromsoundpressuremeasuredintheearcanal.Inthisstudy,anovelsignalprocessingmethodformulticomponentanalysis(MCA)wasusedtomeasuretheamplitudeanddelayoftheSFOAE.Thisreportshowsthedelay-frequencydistributionoftheSFOAEmeasuredfromthehumanear.AlowlevelacousticalsuppressorneartheprobetonesignificantlysuppressedtheSFOAE,stronglyindicatingthattheSFOAEwasgeneratedatcharacteristicfrequencylocations.Informationderivedfromthismethodmayrevealmoredetailsofcochlearmechanicsinthehumanear.

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简介：Objectives:TofindoutthelevelandfunctionsofChlamydiatrachomatisheatshockprotein(C-hsp60)antibody,anti-spermantibody(ASAb),interleukin1(IL-1),interleukin6(IL-6),interleukin8(IL-8),Tumornecrosisfactoralpha(TNF-α)andγ-interferon(IFN-γ/)inpatientswithCT-relatedinfertility.Methods:CT-DNAofcervicalsecretionswasdetectedthroughpolymerasechainreaction(PCR)andmigrationinhibitingfactor(MIF)wasemployedtomeasureIgGtitreofCTMOMPantibody.WesternblotwasusedtodeterminepresenceofC-hsp60antibodyandenzyme-linkedimmunoadsorbentassay(ELISA)measuredASAbofIgGtypeinbloodserumanddeterminethecontentofIL-1,IL-6,IL-8.TNF-u,IFN-7inuterinetubefluid.Results:68patientshadpositiveCT-DNA,amongwhich57(83.8%)hadC-hsp60antibody.Amongthe172patientswithnegativeCT-DNA,64patients(37.2%)alsohadC-hsp60Antibody.Therewasasignificantdifference(P<0.01)betweeninfertilepatientsandcontrolgrouppatientsinthepresenceofASAb.InfertilepatientswithpositiveCT-DNAhadhigherlevelsofIL-1.IL-6.IL-8,TNF-u,IFN-7inuterinetubefluidcomparedtocontrolgrouppatients(P<0.01).Conclusion:Firstly,thosepatientswithnegativeCTtestingfromcervicalsecretionscannotberuledoutforCTinfectionindeeppartsofthebody(suchasoviduct,pelvickidney).DetectionofC-hsp60AntibodymayhelptodiagnosesuchcasesofCT.Secondly,CTinfectionoftheoviductcanraiselevelsofIL-1、IL-6、IL-8、TNF-α、N-γ.ThepathogenesisofinfertilitycausedbyCTinfectioninthereproductivetractmayberelatedtocytokineproductionandinflammatoryresponsesmediatedbyC-hsp60Antibody,IL-1,IL-6,IL-8,TNF-αandIFN-γ.

简介：Objective:Toprovideanatomicalbasisfortheinternalfixationofscaphoidfractures.Methods:Theshapeandvascularlakeof48dryscaphoidsand36wetscaphoidswereobserved.Results:Thedataofdrybonegroupandwetbonegroupwereasfollows:theheightofscaphoidtuberclewere(11.28±0.94)mmand(10.35±1.54)mm;thethicknessofscapoidwaistwere(12.02±1.90)mmand(11.21±1.20)mm;thewidthofscapoidwaistwere(10.59±1.11)mmand(11.34±1.47)mm;theminimalthicknessofthebodyofscapoidwere(6.51±1.22)mmand(8.54±1.07)mm;theaxislengthofscapoidwere(25.68±2.21)mmand(26.50±2.56)mm;thewidthofepicondyleofscaphoidofdistalportion,waistandproximalportionwere(6.50±1.06)mm,(5.14±1.01)nun,(4.42±1.16)mmand(6.64±1.18)mm,(6.01±0.75)mmand(5.71±0.78)mm,respestively.Themainbloodvesselscamefromthedorsalandtheradialofwristandpassedthroughthewholescaphoidalongthecrestofscaphoid.Conclusion:Theinternalfixationofscaphoidcanbedesignedaccordingtotheanatomicaldatawithoutdamag-ingthearticularsurfaceandbloodsupply.

简介：AIM:Toidentifywhethertheforcepsestimationismoreusefulthanvisualestimationinthemeasurementofcolonpolypsize.METHODS:Werecordedcolonoscopyvideoclipsthatincludedscenesvisualizingthepolypandscenesusingopenbiopsyforcepsinassociationwiththepolyp,whichwereusedforanexam.Atotalof40endoscopistsfromtheBusanUlsanGyeongnamIntestinalStudyGroupSociety(BIGS)participatedinthisstudy.Participantswatched40pairsofvideoclipsofthescenesforvisualestimationandforcepsestimation,andwrotedowntheestimatedpolypsizeontheexampaper.Whenanalyzingtheresultsoftheexam,weassessedinterobserverdifferences,diagnosticaccuracy,anderrorrangeinthemeasurementofthepolypsize.RESULTS:Theoverallintra-classcorrelationcoefficients(ICC)ofinter-observeragreementforforcepsestimationandvisualestimationwere0.804(95%CI:0.731-0.873,P<0.001)and0.743(95%CI:0.656-0.828,P<0.001),respectively.TheICCsofeachgroupforforcepsestimationwerehigherthanthoseforvisualestimation(Beginnergroup,0.761vs0.693;Expertgroup,0.887vs0.840,respectively).Theoveralldiagnosticaccuracyforvisualestimationwas0.639andforforcepsestimationwas0.754(P<0.001).Inthebeginnergroupandtheexpertgroup,thediagnosticaccuracyfortheforcepsestimationwassignificantlyhigherthanthatofthevisualestimation(Beginnergroup,0.734vs0.613,P<0.001;Expertgroup,0.784vs0.680,P<0.001,respectively).Theoverallerrorrangeforvisualestimationandforcepsestimationwere1.48±1.18and1.20±1.10,respectively(P<0.001).Theerrorrangesofeachgroupforforcepsestimationweresignificantlysmallerthanthoseforvisualestimation(Beginnergroup,1.38±1.08vs1.68±1.30,P<0.001;Expertgroup,1.12±1.11vs1.42±1.11,P<0.001,respectively).CONCLUSION:Applicationoftheopenbiopsyforcepsmethodwhenmeasuringcolonpolypsizecouldhelpreduceinter-observerdifferencesanderrorrates.

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简介：ＭＩＣＲＯＰＲＯＣＥＳＳＯＲ－ＢＡＳＥＤＳＹＳＴＥＭＦＯＲＭＥＡＳＵＲＥＭＥＮＴＯＦＢＩＯＥＬＥＣＴＲＩＣＡＬＩＭＰＥＤＡＮＣＥＤＵＲＩＮＧＨＥＭＯＤＩＡＬＹＳＩＳＭＩＣＲＯＰＲＯＣＥＳＳＯＲ－ＢＡＳＥＤＳＹＳＴＥＭＦＯＲＭＥＡＳＵＲＥＭＥＮＴＯＦＢ...

简介：Invasivefractionalflowreserve(FFR)measurementiscurrentlythegoldstandardforcoronaryintervention.FFRmeasurementbycoronarycomputedtomographyangiography(FFRCT)isanovelandpromisingimagingtechnologythatpermitsnoninvasiveassessmentofphysiologicallysignificantcoronarylesions.FFRCTiscapableofcombiningtheanatomicinformationprovidedbycoronarycomputedtomographyangiographywithcomputationalfluiddynamicstocomputeFFR.Todate,severalstudieshavereportedthediagnosticperformanceofFFRCTcomparedwithinvasiveFFRmeasurementasthereferencestandard.FurtherstudiesarenowbeingimplementedtodeterminetheclinicalfeasibilityandeconomicimplicationsofFFRCTtechniques.ThisarticleprovidesanoverviewanddiscussestheavailableevidenceaswellaspotentialfuturedirectionsofFFRCT.

简介：Neurochirurgie,2008Jun21.INTRODUCTION:Neoangiogenesisisacriticalfeaturethatcandifferentiatehigh-gradefromlow-gradeglioma.Conven-tionalMRimagingdoesnotassessthishistologicalfeatureaccurately.Thegoalofthisstudywastoevaluatethegaininrel-ativecerebralbloodvolumemeasurementusingperfusionMRIinthemanagementofcerebralgliomas.MATERIALSAND

简介：Havingawiderangeofmotion,thecervicalspineisratherpredisposedtotrau-maandotherdisorderswithseriousconsequences.Themotionofcervicalspineisacomplexonecomposedofmicromotions,includinghorizontaldisplacementsalongallthreeaxesandrotationsaroundthemwithsixfreedomdegreesofmovement.Reportonprecisemeasurementofthethree-dimensionalmotionofthecervicalsectionof

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简介：ObjectiveTotestCalciumion(Ca2+)flowattheheadandendofouterhaircells(OHCs)inrestingstateandinresponsetoNimodipinetreatment.MethodsNon-invasivemicro-testtechniqueswereusedtostudyCa2+inisolatedOHCsinadultguineapigs.ResultsFourtypesofCa2+transportwereidentifiedinOHCsonbasilarmembranetissuefragments:influxattheheadofwitheffluxatthebottom(type1):effluxattheheadofOHCswithinfluxatthebottom(type2);influxatthebothheadandbottom(type3);andeffluxatthebothheadandbottom(type4).However,onlytype1andtype3ofCa2+iontransportweredetectedinthecochlea.WeproposethatCa2+iontransportexistsinadultguineapigcochlearOHCsinrestingstateandisvariable.Ca2+flowinOHCcanbeinhibitedbyNimodipineinrestingstate.

简介：spinalmotionpivot,spinalmanipulation,theangleoffacetjoint,forcedirection,cylinderpivotmotiontheoryThespinaljointconsistsofadiscandposteriorfacetjoints.Itisthebiomechanicalstructurethatenablesthespinewithsix(6)freedomsofmovementsofflexion/extension,sidebendsandrotations.Weidentifiedthatthesamespinaljointsinitiate,eliminateandcontrolspinalmovement.Thesefourjointsaretheatlanto-occipitalandtheatlanto-odontoidjoints,C7/T1,T12/L1andL5/S1.Theword“pivot”iscommonlyusedtodescribeanimportantruruingporintormatterinChineselanguage.Wedefinetheabovefourjointsas“pivots”inthisarticle.Thejointsarebriefedas“Occipital-vertebralpivot”(atlanto-occipitalandatlanto-odontoidjoint),“cervicalthoracicpivot”(C7/T1),“thoracic-lumbarpivot”(T12/L1)and“lumbar-sacrumpivot”(L5/S1).Aftermeasuring20humanspinalcolumns(drybones),observingtheanglebetweenthevertebralbodyandtheinferiorarticularfaeet,reviewingthespinalanatomyandbiomechanicsandanalyzingtheChinesespinalmanipulationtechniquesandtheory,thefollowingisourreport:

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简介：AbstractBackground:Various experimental and clinical studies have reported on coronary microcirculatory dysfunction ( "no-reflow" phenomenon). Nevertheless, pathogenesis and effective treatment are yet to be fully elucidated. This study aimed to measure the intracoronary pressure gradient in the no-reflow artery during emergent percutaneous coronary intervention and explore the potential mechanism of no-reflow.Methods:From September 1st, 2018 to June 30th, 2019, intracoronary pressure in acute myocardial infarction patient was continuously measured by aspiration catheter from distal to proximal segment in the Department of Coronary Care Unit, Tianjin Chest Hospital, respectively in no-reflow arteries (no-reflow group) and arteries with thrombolysis in myocardial infarction-3 flow (control group). At least 12 cardiac cycles were consecutively recorded when the catheter was pulled back. The forward systolic pressure gradient was calculated as proximal systolic pressure minus distal systolic pressure. Comparison between groups was made using the Student t test, Mann-Whitney U-test or Chi-square test, as appropriate.Results:Intracoronary pressure in 33 no-reflow group and 26 in control group were measured. The intracoronary forward systolic pressure gradient was －1.3 (－4.8, 0.7) and 3.8 (0.8, 8.8) mmHg in no-reflow group and control group (Z = －3.989, P < 0.001), respectively, while the forward diastolic pressure gradient was －1.0 (－3.2, 0) and 4.6 (0, 16.5) mmHg in respective groups (Z = －3.851, P < 0.001). Moreover, the intracoronary forward pressure gradient showed significant difference between that before and after nicorandil medication (Z=－3.668, P < 0.001 in systolic pressure gradient and Z =－3.530, P < 0.001 in diastolic pressure gradient).Conclusions:No reflow during emergent coronary revascularization is significantly associated with local hemodynamic abnormalities in the coronary arteries. Intracoronary nicorandil administration at the distal segment of a coronary artery with an aspiration catheter could improve the microcirculatory dysfunction and resume normal coronary pressure gradient.Clinical trial registration:www.ClinicalTrials.gov (No. NCT 03600259).

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