简介：Thepaperpresentsamulti-scalemodellingapproachforsimulatingmacromoleculesinfluidflows.Macromoleculetransportatlownumberdensitiesisfrequentlyencounteredinbiomedicaldevices,suchasseparators,detectionandanalysissystems.Accuratemodellingofthisprocessischallengingduetothewiderangeofphysicalscalesinvolved.Thecontinuumapproachisnotvalidforlowsoluteconcentrations,butthelargetimescalesofthefluidflowmakepurelymolecularsimulationsprohibitivelyexpensive.Apromisingmulti-scalemodellingstrategyisprovidedbythemeta-modellingapproachconsideredinthispaper.Meta-modelsarebasedonthecoupledsolutionoffluidflowequationsandequationsofmotionforasimplifiedmechanicalmodelofmacromolecules.Theapproachenablessimulationofindividualmacromoleculesatmacroscopictimescales.Meta-modelsoftenrelyonparticle-correctoralgorithms,whichimposelengthconstraintsonthemechanicalmodel.Lackofrobustnessoftheparticle-correctoralgorithmemployedcanleadtoslowconvergenceandnumericalinstability.AnewFAstLinearCOrrector(FALCO)algorithmisintroducedinthispaper,whichsignificantlyimprovescomputationalefficiencyincomparisonwiththewidelyusedSHAKEalgorithm.ValidationofthenewparticlecorrectoragainstasimpleanalyticsolutionisperformedandimprovedconvergenceisdemonstratedforssDNAmotioninalid-drivenmicro-cavity.

简介：Oneofmanyinterestingresearchactivitiesinbiofluidmechanicsisdedicatedtoinvestigationsoflocomotioninwater.Someofpropulsionmechanismsobservedintheunderwaterworldareusedinthedevelopmentprocessofunderwaterauto-nomicvehicles(AUV).Inordertocharacteriseseveralsolutionsaccordingtotheirmanoeuvrability,influenceonthesur-roundingfluidandenergeticefficiency,adetailedanalysisoffin-likemovementisindispensable.Inthecurrentpaperananalysisofundulatory,oscillatoryandcombinedfin-likemovementsbymeansofnumericalsimulationiscarriedout.TheconservationequationofmassandtheconservationequationofmomentumaresolvedwiththeFiniteVolumeMethod(FVM)byuseofthesoftwareCFX-10.0.Theundulatoryandoscillatoryfinmovementsaremodelledwithanequationthatisimplementedwithinanadditionalsubroutineandjoinedwiththemainsolver.Numericalsimulationsarecarriedoutinthecomputationaldomain,inwhichonefinisfixedinaflow-throughwaterduct.SimulationsarecarriedoutintherangeoftheRenumberupto105.Theresultsshowsignificantinfluenceofappliedfinmotiononthevelocitydistributioninthesurroundingfluid.

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简介：FrederickSanger(1980NoblePrizeLaureatesforChemistry)exploresthetechnologyofDNAsequencing.Sangerandcolleaguesusethetechniquetodeterminethesequenceofall5,375nucleotidesofthebacteriophagephi-X174,thefirstcompletedeterminationofthegenomeofanorganism.

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简介：Overthelastdecade,computationalmethodshavebeenintensivelyappliedtoavarietyofscientificresearchesandengi-neeringdesigns.Althoughthecomputationalfluiddynamics(CFD)methodhasplayedadominantroleinstudyingandsimu-latingtransportphenomenainvolvingfluidflowandheatandmasstransfers,inrecentyears,othernumericalmethodsforthesimulationsatmeso-andmicro-scaleshavealsobeenactivelyappliedtosolvethephysicsofcomplexflowandfluid-interfaceinteractions.Thispaperpresentsareviewofrecentadvancesinmulti-scalecomputationalsimulationofbiomimeticsrelatedfluidflowproblems.Thestate-of-the-artnumericaltechniques,suchaslatticeBoltzmannmethod(LBM),moleculardynamics(MD),andconventionalCFD,appliedtodifferentproblemssuchasfishflow,electro-osmosiseffectofearthwormmotion,andself-cleaninghydrophobicsurface,andthenumericalapproachesareintroduced.Thenewchallengingofmodellingbiomi-meticsproblemsindevelopingthephysicalconditionsofself-cleanhydrophobicsurfacesisdiscussed.

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简介：曾经一年一度汇集亚洲政界、商界精英的博鳌亚洲论坛，今年又迎来了中国科协2004年学术年会。本届年会由中国科协和海南省人民政府主办。11月2013美丽的万泉河畔鲜花吐艳，鼓乐阵阵。上午9点，大会隆重开幕。3000多名科技精英，包括60余院士聚集于此，

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简介：北京生理科学会2004年学术年会于11月12日在中国农业大学和解放军总装备部航天医学工程研究所举行。那天天气突然转冷，出现了入冬以来的第一次冰冻，并刮着大风，分别来自北京大学医学部、首都医科大学、中国医学科学院、中国科学院、朝阳医院、中国农业大学等单位的会员们，

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