简介:摘要目的探讨肿瘤标志物CA15-3在肝脏疾病中的变化。方法对722例肝脏疾病患者进行CA15-3测定,观察肝癌、肝硬化、肝炎、肝囊肿、肝脓肿各组CA15-3增高比率、增高值进行比较,推算CA15-3用于肝癌诊断的敏感性、特异性、阴阳性预测值、诊断效率。结果CA15-3在肝病中增高比率依次为肝癌16.7%,肝硬化10.1%,肝炎4.7%,三种疾病CA15-3测定值均高于正常对照组,诊断肝癌的敏感性为16.7%,特异性为93.6%,阴性预测值为55.2%,阳性预测值为70.6%,诊断效率56.9%。结论CA15-3测定结果增高并不只限于乳腺癌患者,肝病患者尤其肝癌也有增高,CA15-3亦可作为肝癌诊断的肿瘤标志物。
简介:摘要目的研究与分析肿瘤标志物CEA、CA15-3和CA125对乳腺癌化疗疗效的评估效果。方法选取我院肿瘤科收治的乳腺癌患者50例为对象进行研究,根据其接受化疗前后设为观察组(化疗后)与对照组(化疗前)。于化疗前后对50例患者肿瘤标志物CEA、CA15-3、CA125等进行检测。比较分析两组检测结果。结果经检测,观察组肿瘤标志物CEA、CA15-3、CA125等水平与对照组相比均显著较低,且差异对比P<0.05具有统计学意义;而两组CA15-3诊断准确率与CEA、CA125相比均显著较高,且差异对比P<0.05具有统计学意义。结论乳腺癌患者化疗期间对肿瘤标志物CEA、CA15-3和CA125加强监测,对于评估其疗效具有积极价值,即可作为患者化疗疗效预测的重要指标。
简介:AbstractObjective:Serum tumor markers are seldom considered as diagnostic biomarkers for breast cancer because they lack good sensitivity or specificity. This study aimed to evaluate whether a combination of circulating tumor cells (CTCs) and the serum tumor markers carcinoembryonic antigen (CEA), cancer antigen (CA)125, and CA15-3 might improve their diagnostic performance.Methods:We performed a retrospective case-control study of patients with breast cancer or benign breast diseases (BBD) and healthy female donors (HDs) who underwent preoperative CTC detection and serum tumor marker tests between December 2017 and November 2018. CTC detection and serum tumor marker test results were collected from 177 breast cancer patients, 64 patients with BBD, and 20 HDs. Correlations between CTC, CEA, CA125, or CA15-3 and participants’ clinical characteristics were then analyzed. The diagnostic performances of CTC, CEA, CA125, and CA15-3 were estimated using the area under the receiver operating characteristic curve (AUC). This study was approved by the Institutional Review Board of Sun Yat-sen Memorial Hospital of Sun Yat-sen University, China (approval No. [2018] kuaishendi(75)) on May 24, 2018.Results:CTC, CEA, and CA15-3 were able to distinguish breast cancer patients from controls (BBD+HDs) (P<0.0001, P=0.0006, and P=0.0086, respectively). CTCs were associated with tumor size (P=0.0275) and lymph node involvement (P=0.0373), while CA15-3 was correlated with cancer stage (P=0.01) and lymph node involvement (P=0.001). The AUCs of CTCs, CEA, CA125, and CA15-3 were 0.845, 0.623, 0.477, and 0.58, respectively. CA125, with AUC<0.5, was not considered a biomarker for breast cancer. CEA and CA15-3 had low sensitivities (<10%) but high specificities (>98%). Combination with CTC improved the diagnostic performances of CEA and CA15-3 for breast cancer. CTC_CA15-3 had better diagnostic performance than CTC_CEA, with an AUC of 0.874, a sensitivity of 0.757, and a specificity of 0.905.Conclusion:CTCs, CEA, and CA15-3 are potential diagnostic biomarkers for breast cancer. The diagnostic performance of CEA and CA15-3 may be improved by combination with CTCs.
简介: 摘要:血清肿瘤标志物水平越高可越可以展现出患者病情的严重变化程度,越可以体现出乳腺对恶性肿瘤对人体的产生的严重影响。为了进一步探究讨论血清学肿瘤标志物CA15-3、CEA、CA125、FER对乳腺癌的诊断价值与应用的研究。如今医学的先进和社会的发展,人们对疾病的了解和预防有了更深的认知,乳腺癌早发现、早诊断、早治疗是可以提高乳腺癌患者的生存质量,延长生存期的重要保证。
简介:目的:了解南充市健康人群血清肿瘤标志物CA125,CA15—3,CA19—9的正常参考值范围。方法:采用全自动电化学发光免疫分析法测定1288名健康体检者的血清CA125,CA15—3,CA19—9水平。结果:健康体检人群血清CA199的浓度随着年龄增大而增高,二者呈正相关性,95%位数为23.69U/mL,血清CA125、CA153浓度受年龄因素的影响不大,95%位数分别为28.84U/mL、21.21U/mL。结论:确定肿瘤标志物正常参考范围,应以单侧最大95%位数为参考上限。南充市健康人群血清肿瘤标志物CA19—9、CA125和CA15—3的正常参考值范围分别为23.69U/mL、28.84U/mL和21.21U/mL。
简介:目的探讨糖类抗原(cA)153、CA125、癌胚抗原(CEA)与血清铁蛋白(SF)联合检测对乳腺癌患者的互补诊断价值及在疗效观察中的临床意义。方法利用化学发光免疫方法检测36例乳腺良性疾病(乳腺良性疾病组)和30例健康体检者(对照组)以及70例乳腺癌患者(乳腺癌组)治疗前后血清CA15—3、CA125、CEA和SF的水平,并进行分析。结果乳腺癌组血清CA15—3、CA125、CEA和SF水平明显高于乳腺良性疾病组和对照组(P〈0.05);乳腺癌组血清CA15—3、CA125、CEA和SF治疗前的水平明显高于治疗后的水平(P〈0.05),且治疗前水平明显高于对照组(P〈0.01);四种肿瘤标志物联合检测均高于单一检测,其诊断敏感度达82.8%。结论血清CA15—3、CA125、CEA、SF联合检测可提高乳腺癌的阳性检出率和检测特异性,对乳腺癌的早期诊断、疗效监测以及预后判断均有重要意义。
简介:一年一度的“3·15国际消费者权益日”已经成为广大消费者企盼的节日。每逢佳节来临,各级质监和工商部门,必定会大举出动,进行各种宣传、咨询,受理投诉,免费检测,以及举办文艺活动,这一切似乎已成为惯例,究其目的只有一个,帮助广大消费者维护自己正当的、合法的权益。作为消费者,特别是那些吃了亏,上了当,受到侵害,有质量纠纷而无处诉的消费者,想在这一天,这一举国的活动中讨回公道。这一天,全国大小城市都将会热热闹闹。从“安全健康消费”,“明明白白消费”到今年的“质量:关系生命安全,关系百姓生活”的活动主题,无非是让消费者懂得消费过程中如何保护自己而免受损失和遭受不
简介:今年已经是"3·15"(国际消费者权益日)走过的第26个年头了,也是中国改革开放伟大历程的第31个年头。回首这30年的光辉历程,我总会想起罗马神话中的那位看门神雅努斯。神每天都会把天空的大门打开,让阳光普照大地。黄昏来临时