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简介：Therearefewstudiesontheneuroprotectiveeffectsofsyringaldehydeinaratmodelofcerebralischemia.Thestudyaimedtoelucidatethemechanismsunderlyingtheneuroprotectiveeffectsofsyringaldehydeonischemicbraincells.Ratmodelsofcerebralischemiawereintraperitoneallyadministeredsyringaldehyde.At6and24hoursaftersyringaldehydeadministration,celldamageinthebrainofcerebralischemiaratswasobviouslyreduced,superoxidedismutaseactivityandnuclearrespiratoryfactor1expressioninthebraintissueweremarkedlyincreased,malondiadehydelevelwasobviouslydecreased,apoptosis-relatedcysteinepeptidasecaspase-3and-9immunoreactivitywasobviouslydecreased,andneurologicalfunctionwasmarkedlyimproved.Thesefindingssuggestthatsyringaldehydeexertsneuroprotectiveeffectsoncerebralischemiainjurythroughanti-oxidationandanti-apoptosis.

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简介：Angiogenesis是一个很复杂的生理的过程，它包含依赖于在生长因素(激发器和禁止者)之间的homeostatic平衡的多重小径。这个紧控制的过程被angiogenic因素刺激，它在肿瘤以内是在场的并且包围联系肿瘤的stromal房间。angiogenesis上的肿瘤繁殖，侵略和转移的依赖为对待恶意使新血容器形成的禁止者成为吸引人的药。Angiogenesis能被几不同机制破坏：由禁止endothelial房间，由打断发信号的小径或由禁止angiogenesis的另外的使活跃之物。这策略在稳固的肿瘤的几种类型显示出治疗学的利益，导致食物药品管理局(食物及药品管理局)在肾，非小的房间肺，结肠和大脑的治疗的anti-angiogenic代理人的赞同癌症。尽管没有angiogenesis禁止者与变形前列腺癌症为病人被同意了，指向新血容器形成的治疗仍然是前列腺癌症研究的一个新兴、有希望的区域。

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简介：Cancercellsarewelldocumentedtorewiretheirmetabolismandenergyproductionnetworkstosupportandenablerapidproliferation,continuousgrowth,survivalinharshconditions,invasion,metastasis,andresistancetocancertreatments.SinceDr.OttoWarburg’sdiscoveryaboutalteredcancercellmetabolismin1930,thousandsofstudieshaveshedlightonvariousaspectsofcancermetabolismwithacommongoaltofindnewwaysforeffectivelyeliminatingtumorcellsbytargetingtheirenergymetabolism.Thisreviewhighlightstheimportanceofthemainfeaturesofcancermetabolism,summarizesrecentremarkableadvancesinthisfield,andpointsoutthepotentialstotranslatethesescientificfindingsintolife-savingdiagnosisandtherapiestohelpcancerpatients.

简介：BackgroundTheclinicalcharacteristicsofstrokepatientstreatedwithdoubleanti-platelettherapy(DAPT)afterpercutaneouscoronaryintervention(PCI)isnotclear.MethodsIntotal,2675patientsunderwentPCIandDAPTinGuangdongGeneralHospital,and68outofthemwerehospitalizedduetosuspectedstroke,ofwhom23werediagnosedashavingstroke.Dataofthe23strokepatientswerecollectedandtraditionalriskfactorsassociatedwithstrokewereanalyzedretrospectively.ResultsThemeanageofthesepatientswas75.6±8.7years,and20(87.0%)weremales.Notably,19patientswerecomplicatedwithhypertension,7withdiabetesmellitus,7withprevioushistoryofstroke,nonewithatrialfibrillation(AF)orpatentforamenovale(PFO).Specifically,22patientswerediagnosedwithischemicstroke,and1patientwithhemorrhagicstroke.ConclusionStrokeinpatientstreatedwithDAPTafterPCIwascorrelatedwithadvancedage,gender,hypertension,diabetesmellitus,strokehistory.Longtermelectrocardiography(ECG)maybeneededforthediagnosisofAF,whiletrans-esophagealechocardiography(TEE)maybeneededforPFO.

简介：BackgroundAdvancedpracticenursetransitionalcarehasbeenproofedtobeimportantforolderadultswithchronicconditions.However,sucheffectivenesshasneverbeenstudiedinthemanagementofappropriateWarfarinuseinclinicalpractice.MethodsAtotalof97patientswererandomlydistributedintocontrolgroupwhoreceivedusualcare,andinterventionalgroupwhoreceivedtransitionalcareprovidedbyAPNs.A12-monthobservationofbothgroupswererecordedbyphysiciansandAPNsandtheimpactofAPNsonthemanagingofWarfarintherapywasalsoevaluatedbasedontimeinthetherapeuticrange(TTR).ResultsAPNstransitionalcaresignificantly(P<0.01)improvedpatients’adherence,increasedTTRandhighTTRratiocomparedwithcontrolgroup.Re-admissionduetostrokewassignificantly(P<0.01)reducedbyAPNstransitionalcare.ConclusionAPNstransitionalcareimprovespatients’knowledgeonAFandreducesstrokerisk.ThecurrentresearchstronglysuggestthenecessityofAPNstransitionalinterventionalinmanaginganticoagulationtherapyinAFpatientsinChina.

简介：在忍冬装饰用的梨树花的di-O-caffeoylquinic酸(diCQAs)的三种类型的抗菌剂活动，繁体中文药(TCM)，在杆菌shigae上，生长被microcalorimetry调查并且比较。diCQAs的三种类型是3，4-di-O-caffeoylquinic酸(3，4-diCQA)，3，5-di-O-caffeoylquinic酸(3，5-diCQA)，并且4，5-di-O-caffeoylquinic酸(4，5-diCQA)。新陈代谢的力量时间上的三diCQAs的效果的质、量的信息弄弯的一些，生长率常数k，最大的热产量力量下午，和产生预定tG，全部的热产量Qt，和生长禁止的比率我B。shigae是计算的。根据一个thermo运动的模型，k，下午，Qt，我和c的相应量的关系被建立。另外，这些药(IC50)的一半禁止的集中被定量分析获得。基于数量活动关系和IC50价值，禁止的活动的顺序是3，5-diCQA>4，5-diCQA>3，4-diCQA。结果说明在C-5的caffeoyl酉旨组是为细菌的房间有一种更高的亲密关系的主要的组的可能性，并且二caffeoyl酉旨的intramolecular距离组织，这也在diCQAs的抗菌剂活动有重要影响。

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简介：AIM:JS-38(mitothiolore),asyntheticversionofametaboliteisolatedfromXenorhabdussp.,wasevaluatedforitsanti-tumorandwhitebloodcell(WBC)elevatingactivities.METHOD:Theseanti-proliferativeactivitieswereassessedinvitrousingapaneloftencelllines.Theanti-tumoractivitiesweretestedinvivousingB16allograftmousemodelsandxenograftmodelsofA549humanlungcarcinomaandQGYhumanhepatomainnudemice.Theanti-tumorinteractionsofJS-38andcyclophosphamide(CTX)or5-fluorouracil(5-Fu)werestudiedinaS180sarcomamodelinICRmice.SpecificstimulatoryeffectsweredeterminedonperipheralneutrophilsinnormalandCTX-and5-Fu-inducedneutropenicmice.RESULTS:TheIC50valuesrangedfrom0.1to2.0μmol·L-1.JS-38(1μmol·L-1)causedanincreaseinA549tumorcellapoptosis.Multi-dailygavageofJS-38(15,30,and60mg?kg-1?d-1)inhibitedinvivotumorprogressionwithoutasignificanteffectonbodyweight.JS-38additivelyenhancedtheinvivoanti-tumoreffectsofCTXor5-Fu.JS-38increasedperipheralneutrophilcountsandneutrophilratesinnormalBALB/cmicealmostaseffectivelyasgranulocytecolony-stimulatingfactor(G-CSF).InmicewithneutropeniainducedbyCTXor5-Fu,JS-38rapidlyrestoredneutrophilcounts.CONCLUSION:TheseresultssuggestthatJS-38hasanti-tumoractivity,andalsohastheabilitytoincreaseperipheralbloodneutrophils.

简介：Objective:Theepidermalgrowthfactorreceptor(EGFR)inhibitorsmonoclonalantibodies(MoAbs)havealreadyshownthetherapeuticeffectivenessinpatientswithmetastaticcolorectalcancer(mCRC).Butmanypatientsresisttothetreatment.Theaimofthismeta-analysiswastoassessEGFRgenecopynumber(GCN)asacandidatepredictivebiomarkerforresistancetoanti-EGFRMoAbsinmCRCtreatment.Methods:SystematiccomputerizedsearchesofthePubMed,EMBaseandCochraneLibrarywereperformed.Theprimaryendpointwasobjectiveresponserate(ORR).Thesecondendpointsincludedprogression-freesurvival(PFS),andoverallsurvival(OS).Thepooledoddratio(OR)andpooledsensitivity,specificity,andsummaryreceiveroperatorcharacteristic(SROC)forORRwereestimated.Thepooledhazardratios(HR)forPFSandOSwerealsocalculated.Results:Fourteenstudieswith1,021patientswereincluded.IncreasedEGFRGCNwasassociatedwithincreasedORR(OR=6.905;95%CI:4.489-10.620).Itwasalsofoundinwild-typeKRASmCRCpatients,withthepooledORof8.133(95%CI:4.316-15.326).GCNhasmediumvalueforpredictingORR,withthepooledsensitivityof0.79(95%CI:0.73-0.84),thepooledspecificityof0.59(95%CI:0.55-0.62).InwildtypeKRASmCRCpatients,thesensitivityandthespecificitywere0.80(95%CI:0.70-0.87)and0.60(95%CI:0.53-0.66),respectively.IncreasedEGFRGCNwasassociatedwithincreasedPFS(HR=0.557;95%CI:0.382-0.732)andOS(HR=0.579;95%CI:0.422-0.737).Conclusions:Thismeta-analysissuggeststhatEGFRGCNrepresentsapredictivebiomarkerfortumorresponseinmCRCpatientstreatedwithMoAbsregardlessofKRASmutation.mCRCpatientswithincreasedEGFRGCNaremorelikelytohaveabetterresponse,PFS,andOSwhentreatedwithcetuximaborpanitumumab.

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简介：免疫疗法和化疗的联合为癌症的某些类型的治疗被认为是一条有希望的途径。然而，内在的机制需要充分被调查为癌症chemoimmunotherapy指导更有效的协议的设计。联系危险的分子的模式(阻尼)能激活有免疫力的房间，是众所周知的，包括树枝状的房间(DC)，经由像使用费的受体(TLR)；然而，在有免疫力的反应的激活免除化学对待药的肿瘤房间的阻尼的角色需要进一步被阐明。这里，我们发现那colorectal与oxaliplatin(OXA)对待的癌症(CRC)房间或5氟尿嘧啶(5-Fu)释放了高活动性的组盒子1的高水平(HMGB1)和热吃惊蛋白质70(HSP70)。在OXA/5-Fu治疗以后，也展出的CRC病人的sera增加了HMGB1和HSP70的层次，哪个是著名阻尼。与OXA/5-Fu对待的垂死的CRC房间的上层清液支持了老鼠和人的DC成熟，与HLA医生，CD80和CD86表示和IL-1β的改进的upregulation；，TNF-α；，MIP-1α；，MIP-1β；，RANTES和IP-10生产。由DC组成的疫苗与导致的化学上强调的CRC房间的上层清液搏动了更重要的IFN-γ；在vitro并且在vivo生产Th1反应。然而，化学上强调的CRC房间的上层清液没能在TLR4缺乏的DC导致phenotypic成熟和cytokine生产，显示在导致阻尼的DC成熟和激活的TLR4的一个必要角色。而且，有化学上强调的CRC房间的上层清液的pulsing高效地没导致IFN-γ；在TLR4缺乏的DC生产Th1反应。一起，这些结果证明免除化学上强调的癌症房间的阻尼能经由TLR4激活DC并且提高反肿瘤T房间有免疫力的回答的正式就职，描出一条临床上相关的免疫助手小径由阻尼被触发。

简介：T助手(Th)系被在极化期间与anti-CD3/CD28抗体激活CD4房间在vitro产生了。然而，生理地，Th系的产生被介绍抗原的房间(APC)被有特定的抗原的激活介绍。这里，我们使用了T房间受体(TCR)当在二个激活模式中的任何一个一个产生了时，比较Th1，Th9和Th17系的显型的转基因的老鼠。对母鸡鸡蛋溶解酵素(司死亡及冥府的女神)特定的系Th房间，采纳地被变成转基因地在他们的透镜表示司死亡及冥府的女神的接受者老鼠。显著差别在Th1，Th9或Th17的系之间被发现，在他们的能力在二个模式中的任何一个一个产生了移居到并且在接受者怒气并且，重要地增殖在接受者老鼠眼睛导致发炎。实质的差别也在他们某些chemokines和chemokine受体的抄本表示侧面在系对之间被观察。然而，令人惊讶地，靠近的类似在三显型的系的抄本表示侧面之间被观察，由一样的模式激活。而且，二个激活模式产生的Th房间系在他们基因表示的模式更加不同，由microarray分析监视了，但是与一样的激活模式产生的另外的显型的系展出了公共。这研究因此证明激活与anti-CD3/CD28抗体产生的(i)Th系不同于antigen/APC产生的系；并且(ii)激活的模式决定主要抄本的表示侧面到大程度。