简介:目的:观察美尔瑞片(中草药灯盏细辛)对眼压控制后的青光眼是否具有视神经保护作用.方法:对99例(113眼)眼压已控制的原发性开角型青光眼及闭角型青光眼进行多中心、前瞻性、随机、双盲对照临床研究,观察口服美尔瑞片6mo后对视野的疗效,本研究采用VFDS视野缺损计分法,从0(无缺损)至20(所有检测点均不可测出).结果:美尔瑞治疗组55例(66眼),安慰剂对照组44例(47眼),治疗前及治疗后2,4,6mo2组的眼压均<15mmHg,2组间同一时期眼压无显著性差异(P>0.05).服美尔瑞2,4,6mo后VFDS净减值分别为0.44±1.60,1.27±2.16及1.42±2.37,呈现随治疗时间延长,视野缺损逐渐好转趋势.对照组2,4,6mo后VFDS净减计分值分别为-0.02±1.5,0.68±1.73和0.40±1.57.VFDS净减值两组间同一时期比较有显著性差异(P<0.05),治疗6mo后有高度显著性差异(P<0.01).结论:灯盏细辛可用于治疗青光眼性视神经病变,有助于扩大/保持视野.
简介:目的:观察和分析角膜塑形镜治疗后角膜形态的变化,评估角膜塑形镜治疗后光学区偏离中心对控制近视的影响。方法:回顾性临床研究。对134例134眼近视患儿配戴角膜塑形镜矫治近视,平均年龄10.66±1.79岁,均取右眼数据进行研究。分别在戴镜前及戴镜后3、6、12、18、24mo检查视力、眼轴和角膜地形图。使用SPSS19.0进行统计学分析。结果:戴镜后3、6、12、18、24mo的光学区偏瞳孔中心距离分别为0.84±0.45、0.77±0.40、0.79±0.41、0.78±0.41、0.79±0.42mm,差异无统计学意义(F=1.187,P=0.319)。戴镜24mo后平均光学区偏中心距离为0.79±0.35mm,眼轴增长均值为0.32±0.30mm。戴镜24mo后平均偏中心距离轻度(<0.5mm)、中度(0.5~1.0mm)、重度(>1.0mm)的眼轴增长分别为0.45±0.34、0.32±0.28、0.23±0.29mm,差异有统计学意义(F=3.825,P=0.024)。戴镜后的平均偏中心距离和眼轴增长经线性回归分析,其线性关系有统计学意义(F=7.246,P=0.008),线性回归方程Y=0.478-0.194X。戴镜24mo后,18眼有重影,其偏中心距离均值1.18±0.36mm;116眼无重影,其偏中心距离均值0.73±0.31mm,偏中心距离比较差异有统计学意义(t=5.59,P<0.01)。结论:光学区偏中心距离在角膜塑形镜治疗3mo后趋于稳定,且对控制近视的效果和视觉质量有影响。
简介:AIM:ToinvestigatetheefficacyofFerrararings(FR)implantationinthetreatmentofkeratoconus.METHODS:Itwasaretrospectivecaseseriesdescriptivestudy.Thesamplewascomprisedof50patients79eyesdiagnosedwithprogressivekeratoconus.Thisincluded24(48%)malesand26(52%)femalesbetweentheageof13and44years.AllparticipantsunderwentsurgicalimplantationofFRintheperiodbetweenJanuary2009andSeptember2010atJordanUniversityHospital.Thoroughophthalmologicexaminationswereappliedtomeasurevitalvariablesforeachpathologicalconditionbeforeandaftersurgery.RESULTS:Findingsindicatedanoverallsignificantpostoperativeimprovementinbothuncorrectedvisualacuity(UCVA)andbestspectaclecorrectedvisualacuity(BSCVA)throughoutfollowupvisits.Moreover,resultsillustratedasignificantdecreaseinsphericalequivalent(SE)andkeratometricreadings(lower,higherandtheaverage).CONCLUSION:Surgicalinterventionstrategiesarebeingfrequentlydevelopedtomeettheneedsofpatientswithkeratoconus.TheimplantationofFerrararingshasproventobeasafeandfeasiblealternativeprocedureforthetreatmentofmild-moderatekeratoconusespeciallyforpatientswithcontactlensesintolerance.Wehavefoundthatthisprocedurehasimprovedvisualoutcomesinalleyesstudied.Nevertheless,furtherresearchisneededtoinvestigatelongtermoutcomes.
简介:目的:通过光学相干断层扫描(opticalcoherencetomography,OCT)观察视网膜色素变性(retinitispigmentosa,RP)患者黄斑中心凹的厚薄改变及黄斑部图片特点。方法:选取2014-09/2016-09在本院门诊确诊的RP患者74例148眼,同时选取50例100眼正常人作为对照。对两组进行OCT检测和眼底拍照,观察患者视网膜黄斑部位的图像特征,并对患者眼底拍照的结果进行对比,测量黄斑中心凹颞侧面4mm位置、乳头黄斑束中点及黄斑中心凹厚度。结果:对两组研究对象测量视网膜厚度显示,RP患者黄斑中心凹视网膜和中心凹颞侧部4mm厚度与正常人相比,差异无统计学意义(P〉0.05);RP患者乳头黄斑束中点厚度变薄,与正常人对比差异有统计学意义(P〈0.05);RP患者黄斑区OCT检测图像表征有5种类型:视网膜黄斑区域水肿者19例38眼;视网膜色素脉络膜毛细血管层和上皮层变薄者18例36眼;视网膜色素上皮层发生萎缩者12例24眼;黄斑部视网膜厚度正常者12例24眼;色素上皮层厚薄表现不一者13例26眼。结论:OCT能在前期及时地发现RP患者黄斑部位的病变,帮助患者深入了解病情发展,为患者早期诊疗提供了临床依据。
简介:AIM:Toevaluatetheefficacy,safetyandstabilityofposteriorchamberphakicintraocularlensimplantationforthecorrectionofhighmyopia.METHODS:Retrospectivecasereviewof82eyes(43patients)undergoingimplantableColiamerlens(ICL)placementbyasinglesurgeon(Xiao-WeiGao)tocorrectpreoperativemeansphericalequivalentsbetween-9.00diopter(D)and-23.00D.Mainoutcomemeasuresincludeduncorrectedvisualacuity(UCVA),refraction,bestspectacle-correctedvisualacuity(BSCVA),endothelialcelldensity(ECD),intraocularpressure(IOP),lenstransparency,postoperativeuveitis.Visanteanteriorsegmentopticalcoherencetomography(AS-OCT)wasusedtomeasureanteriorchamberdepth(ACD)andthepositionofICL.RESULTS:Meanfollow-upwas6.54±3.26months(range3-12months).Predictabilityofthemanifestsphericalequivalent(SE)refractiontowithin±1.OODwasachievedin88%ofeyesand±0.50Din72.5%ofeyes.ThemeanpostoperativemanifestSErefractionwas-1.85±0.72D,with96.34%ofeyesmaintainingorgaining≥1line(s)ofBSCVA.Themean3-monthpostoperativeECDdecreasedbuthadnostatisticallydifferencecomparedwiththepreoperativeECD.Ofthe7eyes(8.54%)withamildtransientincreaseinintraocularpressure(upto30mmHg),nonerequiredasecondsurgicalprocedureorprolongedtopicalmedication.Therewasnolossoflenstransparency.Pigmentedprecipitateswereobservedin5eyes(6.09%).ThemeanpreoperativeACDmeasuredwithAS-OCTwas3.28±0.14mm,threemonthsaftersurgery,themeanACDwas2.45±0.22mm.Anteriorchamberdepthshowedastatisticallysignificantreduction.Oneeye(1.22%)hadICLspontaneousrotation,81eyes(98.78%)ofthelensremainedcorrectlycentered.CONCLUSION:TheimplantationofICLisaneffectivesurgicaloptionforthemanagementofhighmyopia.Butitslongtimeeffectandsafetystillneedmoretimetoprove.
简介:AIM:Toevaluatetheefficacyofintralesionalradiofrequencyablationinthetreatmentofperiorbitalsyringomas.·METHODS:Wetriedtheintralesionalradiofrequencyablationfor64patientswithperiorbitalsyringomasfrom2007to2011.Theoperationwasperformedunder2.5loupemagnifications.Thehandpiecewasassembledwithaneedleelectrodeandconnectedtotheradiofrequencyablationapparatus.Theelectrodewastheninsertedintothetargetlesionsindermisanddeliveringinjurytothebaseofthesetumors.Resultswereassessedclinicallybycomparingpre-andpost-treatmentphotographsandpatientsatisfactionrates.·RESULTS:Clinicalimprovementincreasedwitheachsubsequenttreatmentsession.Thepercentofpatientswhoseclinicimprovementgradewere≥3aftereachsessionwasrespectively71.9%(Session1),83.3%(Session2),and100%(Session3).Thestatisticalresultsindicatedtheconcordanceoftheclinicalassessmentandthesatisfactionlevelofpatients(kappa=0.78ofthesession1;kappa=0.82ofthesession2).Themajorityofpatientshadgoodorexcellentcosmeticresults.Postoperatively,therewerenopermanentsideeffectsorrecurrences.·CONCLUSION:Asanewtechniqueofminimallyinvasion,theintralesionalradiofrequencyablationwasfoundtobeaneffective,inexpensive,highlypreciseandsafewayoftreatingperiorbitalsyringomas.
简介:目的:通过多焦视网膜电图(multifocalelectroretinography,mf-ERG)在中心性浆液性脉络膜视网膜病变(centralserouschorioretinopathy,CSC)治疗前后的观察,提高CSC诊断的准确性,并指导临床诊疗,评估预后。方法:设置有比较性的CSC观察组和双眼正常的对照组。观察组有31例CSC患者都是单眼发病,这些患者每只眼(包括患眼与对侧眼)在发病期与恢复期都经过眼科的系统检查,包括最佳矫正视力、眼底荧光血管造影、OCT和mf-ERG,并记录这些检查的数据。对照组有30例,与观察组年龄范围相同,同样做上述检查并记录数据。对两组数据进行对比分析。结果:在CSC发病期,mf-ERG显示患眼平均视网膜振幅密度在1环为60.54±18.20nV/degree2,比对照组(110.94±31.20nV/degree2)低45.43%(P〈0.01),在2环为38.12±10.81nV/degree2,比对照组(60.91±11.43nV/degree2)低37.42%(P〈0.05)。在恢复期,mf-ERG显示患眼平均视网膜振幅密度在1环为93.71±14.13nV/degree2,比对照组(110.94±31.20nV/degree2)低15.53%(P〈0.05);在2环为51.16±10.34nV/degree2,比对照组(60.91±11.43nV/degree2)低16.01%(P〈0.05)。另外,我们还发现,观察组31例患者中有8例对侧眼也显示出异常,平均视网膜振幅密度在1环为62.41nV/degree2,其余23例患者对侧眼未发现异常。结论:多焦视网膜电图有助于中心性浆液性脉络膜视网膜病变患者的临床治疗与随访观察,对中心性浆液性脉络膜视网膜病变患者的诊断、病情评估及预后都起着重要的作用。
简介:目的:探讨糖皮质激素的使用是否是中心性浆液性脉络膜视网膜病变(centralserouschoriorelinopathy,CSCR)发病的危险因子。方法:前瞻性病例对照研究。对连续的100例急性CSCR患者就糖皮质激素的使用状况进行问卷调查。从同期就诊的非CSCR的门诊患者中根据年龄和性别选择病例与之匹配,以建立对照组,并进行相同的问卷回答。结果:在100例CSCR患者中,10例(10%)有激素使用史,男4例,女6例。而100例对照患者中仅有3例(3%)有激素使用史,男2例,女1例。两组之间有显著性差异。结论:通过前瞻性的病例对照研究,我们发现使用糖皮质激素是CSCR发病的危险因子。
简介:AIM:Toreporttheeffectivenessandsafetyofprimary23-Gauge(G)vitreoretinalsurgeryforrhegmatogenousretinaldetachment(RRD).·METHODS:Inthisretrospectivestudy,49eyesof49consecutivepatientswhounderwentprimary23-Gtransconjunctivalsuturelessvitrectomy(TSV)forRRDbetweenJanuary2007andJuly2009atourinstitutionwereevaluated.·RESULTS:Meanfollow-uptimewas8.9±7.7months(1-28months).Retinalreattachmentwasachievedwithasingleoperationin47(95.9%)of49eyes.Intwoeyes(4.1%),retinalredetachmentduetonewbreakswassuccessfullytreatedwithreoperationusingthe23-GTSVsystem.MeanlogMARvisualacuitywas2.01±0.47preoperativelyand1.3±0.5postoperatively(P<0.001,Pairedt-test).Meanpreoperativeintraocularpressure(IOP)was14.1±2.8mmHg.MeanpostoperativeIOPwas12.3±3.6mmHgat1day,13.1±2.1mmHgat1week,14.3±2.2mmHgat1month.Iatrogenicperipheralretinalbreakwasobservedin1eye(2.0%)intraoperatively.Nosutureswererequiredtoclosethescleralorconjunctivalopenings,andnoeyesrequiredconvertionofsurgeryto20-Gvitrectomy.·CONCLUSION:Primary23-GTSVsystemwasobservedtobeeffectiveandsafeinthetreatmentofRRD.
简介:AIM:Todeterminethehistopathologicalchangesofrifampicinappliedintravitreallyonretinalganglioncellsbymeansofstereologicalandhistopathologicalmethods.METHODS:Forthisstudytwenty-fourNewZealandadultrabbitsweredividedintofourgroups(n=6foreachgroup).50μg/0.1mL(group1),100μg/0.1mL(group2),150μg/0.1mL(group3)and200μg/0.1mL(group4),rifampicinwereinjectedintothevitreousoftherighteyesofanimals,theirlefteyeswereusedascontrol(group5).Afterthe28thdayofapplication,animalswereanesthetisedwithxylazine(8mg/kg,IM)andthentheireyeswereenucleatedimmediately.Patternsweretakenawayandeyeswerepreparedforbothstereologicalandelectromicroscopicobservation.RESULTS:Dependingonthehighdoseofrifampicin,somehistopathologicalchangessuchascytoplasmicdilatationanddamagedmembranewereobservedontheelectromicroscopiclevel.Usingquantitativeexamination,whichwasdoneatthelightmicroscopiclevel,itwasshownthatthenumberofneuronsdecreasedlinearlyasrifampicindoseincreasedwhencomparedwiththecontrolgroup.CONCLUSION:Basedonthesefindings,low-doserifampicin(50μg/0.1mL)maybeusefulfortreatmentoftheoculardiseases.
简介:AIM:TotrainTibetanmonkey(Macacathibetana)forintraocularpressure(IOP)measurementinconsciousstateandobtainnormalIOPinconsciousTibetanMacaque.·METHODS:Thetrainingwasbasedonaward-conditionedbehavior.Foodstimulationandhuman-animalinteractionwereusedinthistraining.·RESULTS:TrainedTibetanmonkeyscalmlyacceptedIOPmeasurementbytheTonoVet?誖reboundtonometerwithoutsedationoranesthesiaandtheirIOPvaluesweresimilartootherprimates.·CONCLUSION:Human-cultivatedThibetanmonkeysaretamable,andcanbeusedforbiomedicalresearchsuchasophthalmicresearchwithoutanesthesia.