简介：Inthispaper,acryosurgery-hyperthermiasystemisproposedfortakingadvantageofthealternatedcoolingandheatingtreatmentintumor.Anovelcontrolsystemisproposedtoensurethatthethermalsystemworkseffectively.Firstly,thetissuetemperaturearoundtheprobeisregulatedandkeptinadesiredrangewhenradiofrequencyablationisoperated.Secondly,precisecontroloftemperatureisachievedinhyperthermiatreatmentusingfuzzylogicPIDtypecontroller.Theresultsofexvivoliverexperimentdemonstratethatthissystemcouldprovidearathergoodperformancewiththeproposedcontrolmethod.

简介：MatthiasLtitolfandhisPhDstudent,twoscientistsattheEPFL＇sInstituteofBioengineering,havedevelopedanewtechniqueforusinglaserstocarvepathwaysinhydrogelscaffoldsina3Dcellcultureenvironmenttocontrolthegrowthoftheculture.

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简介：TheroleofthetranscriptionfactorNF-κBinshapingthecancermicroenvironmentisbecomingincreasinglyclear.InflammationalterstheactivityofenzymesthatmodulateNF-κBfunction,andcausesextensivechangesingenomicchromatinthatultimatelydrasticallyaltercell-specificgeneexpression.NF-κBregulatestheexpressionofcytokinesandadhesionfactorsthatcontrolinteractionsamongadjacentcells.Assuch,NF-κBfinetunestissuecellularcomposition,aswellastissues'interactionswiththeimmunesystem.Therefore,NF-κBchangesthecellresponsetohormonesandtocontactwithneighboringcells.ActivatingNF-κBconferstranscriptionalandphenotypicplasticitytoacellandtherebyenablesprofoundlocalchangesintissuefunctionandcomposition.ResearchsuggeststhattheregulationofNF-κBtargetgenesisspecificallyalteredincancer.SuchalterationsoccurnotonlyduetomutationsofNF-κBregulatoryproteins,butalsobecauseofchangesintheactivityofspecificproteostaticmodulesandmetabolicpathways.ThisarticledescribesthemolecularmodeofNF-κBregulationwithafewcharacteristicexamplesoftargetgenes.

简介：AIMTo调查锰superoxidedismutase(MnSOD)的协会有糖尿病的retinopathy(医生)的Val16Ala多型性.METHODSPubMed，Embase，中国知识基础结构，和Wanfang数据库被寻找。分享的机会比率(ORs)和95%信心间隔(CI)被计算评估协会的力量。亚群，敏感，和累积分析被执行。出版偏爱也是analyzed.RESULTSEight研究在分享的分析被包括。MnSODVal16Ala多型性在主导的模型下面与医生的风险被联系(OR=0.66，95%CI=0.48-0.91，P<0.0001)，这结果被表明在累积分析相对稳定。没有重要出版偏爱被发现。这多型性也在主导的模型下面在白种人与医生的风险被联系(OR=0.64，95%CI=0.42-0.97，P=0.04，)并且在在后退的模型下面的亚洲人(OR=0.31，95%CI=0.11-0.88，P=0.03).CONCLUSIONThese调查结果建议MnSODVal16Ala多型性是为医生的一个风险因素，并且更多的注意竟然对这些危险性基因的搬运人被给予。