简介：资料患者男性,35岁。因左侧颈部淋巴结肿大伴皮肤瘙痒半年余就诊。2014年10月血常规：嗜酸性粒细胞计数为4.78×109/L,百分比为43.01%。入院体格检查：左侧颈部及双侧腹股沟可扪及多枚肿大淋巴结,最大约1.5cm×3.0cm,质中,表面光滑,活动可,无压痛。左侧额部可见条索状隆起血管。入院血常规：嗜酸性粒细胞计数为4.70×109/L,百分比达到35．8％。

简介：AIM:Toevaluatetheefficacyofintralesionalradiofrequencyablationinthetreatmentofperiorbitalsyringomas.·METHODS:Wetriedtheintralesionalradiofrequencyablationfor64patientswithperiorbitalsyringomasfrom2007to2011.Theoperationwasperformedunder2.5loupemagnifications.Thehandpiecewasassembledwithaneedleelectrodeandconnectedtotheradiofrequencyablationapparatus.Theelectrodewastheninsertedintothetargetlesionsindermisanddeliveringinjurytothebaseofthesetumors.Resultswereassessedclinicallybycomparingpre-andpost-treatmentphotographsandpatientsatisfactionrates.·RESULTS:Clinicalimprovementincreasedwitheachsubsequenttreatmentsession.Thepercentofpatientswhoseclinicimprovementgradewere≥3aftereachsessionwasrespectively71.9%(Session1),83.3%(Session2),and100%(Session3).Thestatisticalresultsindicatedtheconcordanceoftheclinicalassessmentandthesatisfactionlevelofpatients(kappa=0.78ofthesession1;kappa=0.82ofthesession2).Themajorityofpatientshadgoodorexcellentcosmeticresults.Postoperatively,therewerenopermanentsideeffectsorrecurrences.·CONCLUSION:Asanewtechniqueofminimallyinvasion,theintralesionalradiofrequencyablationwasfoundtobeaneffective,inexpensive,highlypreciseandsafewayoftreatingperiorbitalsyringomas.

简介：AIM:Toestablishanuntransfectedhumancornealstromal(HCS)celllineandcharacterizeitsbiocompatibilitytoacellularporcinecornealstroma(aPCS).·METHODS:PrimaryculturewasinitiatedwithapurepopulationofHCScellsinDMEM/F12media(pH7.2)containing20%fetalbovineserumandvariousnecessarygrowthfactors.Theestablishedcelllinewascharacterizedbygrowthproperty,chromosomeanalysis,tumorigenicityassay,expressionofmarkerproteinsandfunctionalproteins.Furthermore,thebiocompatibilityofHCScellswithaPCSwasexaminedthroughhistologicalandimmunocytochemistryanalysesandwithlight,electronmicroscopies.·RESULTS:HCScellsproliferatedtoconfluence2weekslaterinprimarycultureandhavebeensubculturedtopassage140sofar.AcontinuousuntransfectedHCScelllinewithapopulationdoublingtimeof41.44hoursatpassage80hasbeendetermined.Resultsofchromosomeanalysis,morphology,combinedwiththeresultsofexpressionofmarkerproteinandfunctionalproteinssuggestedthatthecellsretainedHCScellproperties.Furthermore,HCScellshavenotumorigenicity,andwithexcellentbiocompatibilitytoaPCS.·CONCLUSION:Anuntransfectedandnon-tumorigenicHCScelllinehasbeenestablished,andthecellsmaintainedpositiveexpressionofmarkerproteinsandfunctionalproteins.Thecellline,withexcellentbiocompatibilitytoaPCS,mightbeusedforinvitroreconstructionoftissue-engineeredHCS.

简介：AIM:Toevaluatetheefficacyandsafetyofcornealcollagencrosslinking(CXL)topreventtheprogressionofpost-laserinsitukeratomileusis(LASIK)cornealectasia.·METHODS:Inaprospective,nonrandomized,single-centrestudy,CXLwasperformedin20eyesof11patientswhohadLASIKformyopicastigmatismandsubsequentlydevelopedkeratectasia.Theprocedureincludedinstillationof0.1%riboflavin-20%dextranesolution30minutesbeforeUVAirradiationandevery5minutesforanadditional30minutesduringirradiation.Theeyeswereevaluatedpreoperativelyandat1-,3-,6-,and12-monthintervals.Thecompleteophthalmologicexaminationcompriseduncorrectedvisualacuity,bestspectacle-correctedvisualacuity,endothelialcellcount,ultrasoundpachymetry,cornealtopography,andinvivoconfocalmicroscopy.·RESULTS:CXLappearedtostabiliseorpartiallyreversetheprogressionofpost-LASIKcornealectasiawithoutapparentcomplicationinourcohort.UCVAandBCVAimprovementswerestatisticallysignificant(P<0.05)beyond12monthsaftersurgery(improvementof0.07and0.13logMARat1year,respectively).Meanbaselineflattestmeridiankeratometryandmeansteepestmeridiankeratometryreduction(improvementof2.00and1.50diopters(D),respectively)werestatisticallysignificant(P<0.05)at12monthspostoperatively.At1yearafterCXL,meanendothelialcellcountdidnotdeteriorate.Meanthinnestcorneapachymetryincreasedsignificantly.·CONCLUSION:Theresultsofthestudyshowedalong-termstabilityofpost-LASIKcornealectasiaaftercrosslinkingwithoutrelevantsideeffects.Itseemstobeasafeandpromisingproceduretostoptheprogressionofpost-LASIKkeratectasia,therebyavoidingordelayingkeratoplasty.

简介：·Glaucomaisoneoftheleadingcausesofvisualimpairmentandblindnessworldwide.Ofknownriskfactorsforglaucoma,anincreasedinintraocularpressureismosthighlycorrelatedwithglaucomatousdamage.Irrespectiveofthecause,apoptosisoftheretinalganglioncellsistheeventualoutcome.Itiswidelyacceptedthatglaucomaisaneurodegenerativediseasethatisstronglycorrelatedwithcentralnervoussystemdisorders,suchasAlzheimer’sdisease.Thesetwodisordersalsosharesomesimilaritiesinpathogenicmechanisms.Recentstudiessuggestthatthetransientreceptorpotentialcanonical6channelcouldworktogetherwithbrain-derivedneurotrophicfactortopromoteneuronsurvivalinbrainandretina.Inthisstudy,weproposethattransientreceptorpotentialcanonical6maycontributetothepathogenesisofhumanglaucomaandbecomeapotentialtherapeutictarget.

简介：硅油填充术作为目前复杂性视网膜脱离的主流术式,已被广泛应用。由于硅油本身特性,可引起一系列并发症如角膜变性、继发性青光眼、硅油乳化、晶状体混浊等,因此对硅油填充后眼部并发症应重视并积极防治,以提高玻璃体手术的效果。

简介：Massae先生（化名）是一位48岁的农民,最近到坦桑尼亚的一个三级眼科诊所就诊,主诉左眼眼痛、流脓、失明三个星期。在患病的前几天,他在当地的健康中心治疗（氯霉素滴眼液）,但是症状持续加重。现在,他有大面积的角膜溃疡

简介：AIM:Todescribethecharacteristicsofmodulationtransferfunction(MTF)ofanteriorcornealsurface,andobtainthethenormalreferencerangeofMTFatdifferentspatialfrequenciesandopticalzonesoftheanteriorcornealsurfaceinmyopes.·METHODS:Fourhundredeyesfrom200patientswereexaminedunderSIRIUScornealtopographysystem.PhoenisanalysissoftwarewasappliedtosimulatetheMTFcurvesofanteriorcornealsurfaceatverticalandhorizontalmeridiansatthe3,4,5,6,7mmopticalzonesofcornea.TheMTFvaluesatspatialfrequenciesof5,10,15,20,25,30,35,40,45,50,55and60cycles/degree(c/d)wereselected.·RESULTS:TheMTFcurveofanteriorcornealsurfacedecreasedrapidlyfromlowtointermediatefrequency(0-15cpd)atvariousopticalzonesofcornea,thevaluedecreasedto0slowlyathigherfrequency(>15cpd).Withtheincreaseoftheopticalzonesofcornea,MTFcurvedecreasedgradually.3)Intherangeof3mm-6mmopticalzonesofthecornea,theMTFvaluesmeasuredathorizontalmeridianweregreaterthanthecorrespondingvaluesathorizontalmeridianofeachspatialfrequency,thedifferencewasstatisticallysignificant(P<0.05).At7mmopticalzonesofcornea,theMTFvaluesmeasuredathorizontalmeridianwerelessthanthecorrespondingvaluesatverticalmeridianat10-60spatialfrequencies(cpd),andthedifferencewasstatisticallysignificantin25,30,35,40,45,50cpd(P<0.05).·CONCLUSION:MTFcanbeusedtodescribetheimagingqualityofopticalsystemsatanteriorcornealsurfaceobjectivelyindetail.

简介：近视性屈光不正已成为眼科最常见的疾病之一,且发病率呈逐年上升趋势,其中高度近视是常见的致盲病因。一般认为近视的发生、发展是由基因遗传和环境因素共同作用的结果。目前对近视的治疗和预防的方法主要包括光学矫正、药物干预和手术干预。如何通过有效的预防方法来降低近视的患病率是当今眼科领域研究的热点和难点。

简介：<正>先天性第一鳃沟发育异常形成的瘘管在临床上很少见,误诊率很高。笔者收治二例,现报道如下:例1,患者男,21岁,因右耳后反复红肿、流脓8年于1996年5月9日入院。患者8年前无诱因出现右耳后红肿、疼痛,皮肤破溃后流出粘稠黄绿色脓液,排脓后症状消失。此后每年反复出现右耳

简介：AIM:ToIntroduceanewspecializedvisualacuitychartforamblyopicchildrenaged3-5yearsoldanditsclinicalapplications.METHODS:ThenewvisualacuitychartandnotationsweredesignedbasedonWeber-Fechnerlaw.Theoptotypeswereredagainstawhitebackgroundandwerespeciallyshapedfourbasicgeometricsymbols:circle,square,triangle,andcross.Aregulargeometricprogressionoftheoptotypesizesanddistributionwasemployedtoarrangein14lines.Theprogressionrateoftheoptotypesizebetweentwolineswas1.2589andthetestingdistancewas3m.VisualacuityscorecouldberecordedaslogMARnotationordecimalnotation.Agestratifieddiagnosticcriteriaforamblyopiaestablishedbyconsensusstatementondiagnosisofamblyopia(2011)amongmembersoftheStrabismusandPediatricOphthalmologyGroup,OphthalmologySociety,ChineseMedicalAssociation(SPOGOSCMA)wereillustratedinthenewvisualacuitychart.RESULTS:Whenassessingvisualacuityinchildrenaged3-5yearsold,thisnewvisualacuitychartthatconsistsoffoursymmetricalshapes(triangle,square,cross,andcircle)overcameaninabilitytorecognizethelettersofthealphabetanddifficultiesindesignatingthedirectionofblackabstractsymbolssuchasthetumbling’E’orLandolt’C’,whichthesubjectswerepronetoloseinterestin.Thevisualacuityscoremayberecordedindifferentnotations:decimalacuityandlogMAR.Thesetwonotationscanbeeasilyconvertedeachotherintheneweyechart.Themeasurementsofthisnewchartnotonlyshowedasignificantcorrelationandagoodconsistencywiththeinternationalstandardlogarithmicvisualacuitychart(r=0.932,P<0.01),butalsoindicatedahightest-retestreliability(89%ofretestscoreswerewithin0.1logMARunitsoftheinitialtestscore).CONCLUSION:Theresultsofthisstudysupportthevalidityandreliabilityofdistancevisualacuitymeasurementsusingtheneweyechartinchildrenaged3to5yearsoverawiderangeofvisualacuities,andtheneweyechartisgreatforearl

简介：<正>患者,男性,7岁。因发现双眼视力差就诊。自幼聋哑,家族小否认有类似病例。体检:黄发,眉毛内侧较密,双眉相连,颊部斑状色素沉着,高腭弓,四肢皮肤散在色素脱失斑。眼部阳性发现:内眦外移,内眦间距为38mm,睑裂小,虹膜呈淡蓝色。眼底见视网膜血管和脉络膜血管显于白色巩膜之前,黄斑中心凹反光不清;扩瞳后检影:右眼

简介：<正>先诊者(Ⅲ)朱××,男。双眼患先天性上睑下垂,于1979年16岁时来我院眼科门诊作矫治手术。检查:双眼视力1.2。双眼睑裂长21mm;逆向内眦赘皮;内眦间距46mm;上睑下垂,睑裂宽度上、平、下视各为5、4、3mm,压眉弓○。两侧

简介：<正>青光眼致盲危害极大,应引起人们的极度重视。随着我国医疗保健水平的提高,城市青光眼的致盲率已有所降低,但基层地区特别是卫生条件较差的边远地区,人们对青光眼的认识极少,因此青光眼在致盲眼病中仍占主要地位。正确诊治青光眼在基

简介：AIM:Toinvestigatethespecialtyoftranscranialsurgerythroughpterionalapproachforremovalofcranio-orbitaltumors,introducetheophthalmologicalexperiencesofenteringtheorbittoreducetheincidencerateofassociatedcomplicationsofthisoperation.·METHODS:Weperformedaretrospectiveanalysisofaseriesof37casesinvolvingpatientswhounderwenttranscranialsurgerythroughpterionalapproachfortreatmentofcranio-orbitaltumorsinourdepartmentinthepast8years.Pterionapproachcraniotomywasperformedtoallpatients.Afterremovingtumorsintheskullbytheneurosurgeon,ophthalmologistremovedtumorsinorbit.Wetookmeasuresbelowtodecreasecomplications,includinggroundingopticcanalthroughanabrasivedrillingwhennecessary,hangingvariousextraocularmusclestobeexposedforprotection,refrigeratingbyrefrigerationheadstoremovetumors,atlastsewinguporbitseptumaftersurgery.·RESULTS:Tumorswereremovedcompletelyin32cases,andincompletein5casesduetoextensiveinvasionintothecavernoussinusorsphenoidsinus.Ofallthecases,benigntumorsweredemonstratedin28cases(75.6%,28/37)andmalignantin9(24.3%,9/37).Themostcommonlesiontypewasmeningiomain11cases(29.7%,11/37).Extraocularmuscles(EOM)impairment,occurringin21cases(56.7%,21/37),wasthemostfrequentpostoperativecomplication.Themostseriousconsequencewasvisionlossoccurredin4cases(10.8%,4/37).Othercomplications,suchas11casesoftransientblepharoptosis29.7%(11/37),5casesofmydriasisin13.5%(5/7);2casesofcerebrospinalrhinorrheain5.4%(2/37).·CONCLUSION:Cranio-orbitaltumorscanberemovedcompletelyusingtranscranialapproach,andthepterionalapproachoffersexcellentexposure.Cooperationofinterdisciplinaryteamofneurosurgeonsandophthalmologistsconducestofulluseofrespectiveprofessionaladvantages.Theexperienceofophthalmicoperationtechnologycandecreaseoccurrenceofocularcomplicationsaftersurger

简介：AIM:ToinvestigatetheefficacyofFerrararings(FR)implantationinthetreatmentofkeratoconus.METHODS:Itwasaretrospectivecaseseriesdescriptivestudy.Thesamplewascomprisedof50patients79eyesdiagnosedwithprogressivekeratoconus.Thisincluded24(48%)malesand26(52%)femalesbetweentheageof13and44years.AllparticipantsunderwentsurgicalimplantationofFRintheperiodbetweenJanuary2009andSeptember2010atJordanUniversityHospital.Thoroughophthalmologicexaminationswereappliedtomeasurevitalvariablesforeachpathologicalconditionbeforeandaftersurgery.RESULTS:Findingsindicatedanoverallsignificantpostoperativeimprovementinbothuncorrectedvisualacuity(UCVA)andbestspectaclecorrectedvisualacuity(BSCVA)throughoutfollowupvisits.Moreover,resultsillustratedasignificantdecreaseinsphericalequivalent(SE)andkeratometricreadings(lower,higherandtheaverage).CONCLUSION:Surgicalinterventionstrategiesarebeingfrequentlydevelopedtomeettheneedsofpatientswithkeratoconus.TheimplantationofFerrararingshasproventobeasafeandfeasiblealternativeprocedureforthetreatmentofmild-moderatekeratoconusespeciallyforpatientswithcontactlensesintolerance.Wehavefoundthatthisprocedurehasimprovedvisualoutcomesinalleyesstudied.Nevertheless,furtherresearchisneededtoinvestigatelongtermoutcomes.

简介：AIM:Toevaluatetheefficacy,safetyandstabilityofposteriorchamberphakicintraocularlensimplantationforthecorrectionofhighmyopia.METHODS:Retrospectivecasereviewof82eyes(43patients)undergoingimplantableColiamerlens(ICL)placementbyasinglesurgeon(Xiao-WeiGao)tocorrectpreoperativemeansphericalequivalentsbetween-9.00diopter(D)and-23.00D.Mainoutcomemeasuresincludeduncorrectedvisualacuity(UCVA),refraction,bestspectacle-correctedvisualacuity(BSCVA),endothelialcelldensity(ECD),intraocularpressure(IOP),lenstransparency,postoperativeuveitis.Visanteanteriorsegmentopticalcoherencetomography(AS-OCT)wasusedtomeasureanteriorchamberdepth(ACD)andthepositionofICL.RESULTS:Meanfollow-upwas6.54±3.26months(range3-12months).Predictabilityofthemanifestsphericalequivalent(SE)refractiontowithin±1.OODwasachievedin88%ofeyesand±0.50Din72.5%ofeyes.ThemeanpostoperativemanifestSErefractionwas-1.85±0.72D,with96.34%ofeyesmaintainingorgaining≥1line(s)ofBSCVA.Themean3-monthpostoperativeECDdecreasedbuthadnostatisticallydifferencecomparedwiththepreoperativeECD.Ofthe7eyes(8.54%)withamildtransientincreaseinintraocularpressure(upto30mmHg),nonerequiredasecondsurgicalprocedureorprolongedtopicalmedication.Therewasnolossoflenstransparency.Pigmentedprecipitateswereobservedin5eyes(6.09%).ThemeanpreoperativeACDmeasuredwithAS-OCTwas3.28±0.14mm,threemonthsaftersurgery,themeanACDwas2.45±0.22mm.Anteriorchamberdepthshowedastatisticallysignificantreduction.Oneeye(1.22%)hadICLspontaneousrotation,81eyes(98.78%)ofthelensremainedcorrectlycentered.CONCLUSION:TheimplantationofICLisaneffectivesurgicaloptionforthemanagementofhighmyopia.Butitslongtimeeffectandsafetystillneedmoretimetoprove.

简介：在许多低收入和中等收入国家，许多人因为屈光不正服务的不足，缺少一副矫正眼镜而正处于肓或视力损害状态。视觉2020：“享有看见的权利”行动中确定了屈光不正和低视力康复的优先次序，为制定满足屈光不正服务项目需求的发展规划提供了动力。

简介：AIM:Toaddressissuesininteroperabilitybetweendifferentfundusimagesystems,weproposedawebeyepicturearchivingandcommunicationsystem(PACS)frameworkinconformancewithdigitalimagingandcommunicationinmedicine(DICOM)andhealthlevel7(HL7)protocoltorealizefundusimagesandreportssharingandcommunicationthroughinternet.METHODS:Firstly,atelemedicine-basedeyecareworkflowwasestablishedbasedonintegratingthehealthcareenterprise(IHE)EyeCaretechnicalframework.Then,abrowser/serverarchitectureeye-PACSsystemwasestablishedinconformancewiththewebaccesstoDICOMpersistentobject(WADO)protocol,whichcontainsthreetiers.RESULTS:Inanyclientsysteminstalledwithwebbrowser,clinicianscouldlogintheeye-PACStoobservefundusimagesandreports.Multipurposeinternetmailextensions(MIME)typeofastructuredreportissavedaspdf/htmlwithreferencelinktorelevantfundusimageusingtheWADOsyntaxcouldprovideenoughinformationforclinicians.Somefunctionsprovidedbyopen-sourceOviyamcouldbeusedtoquery,zoom,move,measure,viewOICOMfundusimages.CONCLUSION:Suchwebeye-PACSincompliancetoWADOprotocolcouldbeusedtostoreandcommunicatefundusimagesandreports,thereforeisofgreatsignificanceforteleophthalmology.

简介：·AIM:Tostudytheeffectsofdanhonghuayukoufuye(DHK)onfastingbloodglucose(FBG)anddiabeticretinopathy(DR)instreptozotocin(STZ)-inducedtype1diabeticratstofacilitatetherationalusageofthisdrug.·METHODS:DiabeticratswereinducedbyinjectionofasingledoseofSTZintraperitoneallyat50mg/kg.Flashelectroretinogram(FERG)andoscillatorypotentials(OPs)wereusedtomeasureretinalfunction.Themicrovascularperfusionofearswasperformedtostudythemicrocirculationinrats.FBG,body-weight,and24-hurinevolume,waterintakeanddietintakewerealsoassessed.·RESULTS:DHKhadnoeffectonFBGinnormalrats.However,STZ+DHKgroupweresignificantlydifferentfromthoseofModelandmovedtowardthoseofnormalcontrol.Itreversedtheincreaseindietintake(P≤0.05vsmodelcontrol)andthelossinbody-weight(P≤0.05vsmodelcontrol)indiabeticrats.DHKdecreasedtheFBGofdiabeticratsby25.6%(P≤0.05)and37.9%(P≤0.01)after14and21daysadministrationascomparedwiththemodelcontrol,respectively.Moreover,DHKsignificantlyincreasedtheFERGb-waveamplitudeby80%(P≤0.05vsmodelcontrol)anddecreasedtheFERGb-wavelatencyby15.3%(P≤0.01vsmodelcontrol)after24daysadministration.TheOP1andOP2amplitudesinDHKgroupwere2.6(P≤0.01)and2.0(P≤0.01)timesofmodelgroupafter24daysofDHKtreatment,respectively.Atthesametime,OP1andOP2latenciesinDHKgroupreducedby16.0%(P≤0.001)and14.7%(P≤0.001)ascomparedwiththemodelcontrol,respectively.Furthermore,themicrovascularperfusionofDHKgroupwas2.4timesofmodelgroup(P≤0.001)after21daysadministration.·CONCLUSION:DHKhadnoeffectonnormalFBG.Butithadantihyperglycemicactivity,andhadapreventiveandtherapeuticeffectonDRindiabeticrats.·