简介:BackgroundThepurposeofotomicrosurgeryinmoderntimesistoachievecompleteremovalofdisease,whichisthebasisforhearingrehabilitation.Artificialossiclesareimportantforhearingrehabilitation.Oneofthematerialsishydroxyapatitethatactsasossicularreplacementprosthesis(HAprosthesis,PORP&TORP)andiscommonlyusedassubstituteboneinclinics.AlthoughHAprosthesesfeaturegoodbiocompatibility,stabilityandcertainresistancetoinfection,thestructureofthematerialcanbedecomposedandabsorbed.Baseduponanimalexperimentsandclinicalapplication,thisarticleexplorestheinfectivityofHAprosthesesandinfluencingfactors.MaterialsandMethodsHAprostheseswereimplantedinthebullainguineapigs.InfectedHAprostheseswereexaminedunderascanningelectronmicroscope.NinetypatientsimplantedwithHAprostheseswerefollowedformorethan3months.Fivecasesthathadundergonerevisionoperationswerereported.ResultsScanningelectronicmicroscopyshowedthatthenormalcompactstructureshaddisappearedandbecomelooseininfectedHAprostheses,withtheirmicroporesinfiltratedwitheffusion,fibroustissueandinflammatorycells.Asaresult,thenormalceramicstructurewasdecomposedandthemicroporesstructuredisappeared.TheinfectedmesotympanuminthereportedcasesalsoledtoHAinfection.Theshapeandstructureofboneweredestroyed,whichwasvisiblebyvisualexaminationandlightmicroscopy.Theprocessofcholesteatomarecurrencewasalwaysassociatedwithinfection,althoughtheHAprosthesiswassometimesspared.ConclusionWhileHAprosthesisisanti-infectivetosomeextent,long-terminfectionandcholesteatomarecurrencecanleadtodestructionanddecompositionofHAprostheses.Long-terminfectedmiddleearcavity,dysfunctionalEustachiantube,residualandrecurrentcholesteatomaandotherfactorscancausedecompositionofHAprosthesisandresultinhearingloss.
简介:Aone-year-oldbabygirlwithone-monthhistoryofrecurrentpusfluidexudingfromherleftpreauricularsinusorifice,whofailedmultiplecoursesofsurgicaldrainageoftheabscessandpersistentdebridementforthewound,presentedwithMRSAinfection.Thepatientwastreatedwithlinezolidforthreedays.Herpainandparesthesiaresolved,andC-reactiveproteindecreasedtonormal.