学科分类
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6 个结果
  • 简介:Neurochirurgie,2008Jun21.INTRODUCTION:Neoangiogenesisisacriticalfeaturethatcandifferentiatehigh-gradefromlow-gradeglioma.Conven-tionalMRimagingdoesnotassessthishistologicalfeatureaccurately.Thegoalofthisstudywastoevaluatethegaininrel-ativecerebralbloodvolumemeasurementusingperfusionMRIinthemanagementofcerebralgliomas.MATERIALSAND

  • 标签: 神经胶质瘤 诊断方法 大脑 血量
  • 简介:Objective:Thisretrospectivestudyexaminedriskfactorsforcytomegalovirus(CMV)infectionafterumbilicalcordbloodtransplantation(UCBT)andtheimpactofCMVinfectiononpatientsurvival.Methods:Inall176patients,plasmaCMVDNAwasnegativepriortothetransplantation,andexaminedtwiceaweekfor100d,andthenonceweeklyforadditional300d.Preemptiveantiviraltherapy(ganciclovirorfoscarnet)wasstartedinpatientswith>1,000/mLcopiesofCMVDNAbutnofull-blownCMVdisease,andwasdiscontinuedupontwoconsecutivenegativereportsofbloodCMVDNAtest.ThesurvivalandriskfactorsforCMVinfectionordiseasewereexaminedusinglogisticregression.Results:CMVinfectiondevelopedin71%(125/176)ofthepatients,withamedianonsetof32d.Fourpatients(2.3%)developedCMVdisease.Neitherthe5-yearoverallsurvival(OS)norevent-freesurvival(EFS)differedsignificantlyininfectedpatientsvs.thosewithnoinfection(59.4%vs.64.8%,P=0.194;53.4%vs.59.1%,P=0.226).AstepwisemultivariateanalysisindicatedanassociationofCMVinfectionwithage,high-doseglucocorticoids,thenumberoftransplantedCD34+cells,andthenumberofplatelettransfusion,butnotwithgender,theconditioningregimen,andthedayofneutrophilrecoveryandchronicgraft-versushostdisease(cGVHD).Conclusions:CMVinfectionisverycommonafterUCBT,butdoesnotseemtoaffectlong-termsurvivalwithpreemptiveantiviraltreatment.

  • 标签: 巨细胞病毒 病毒感染 脐血移植 危险因素 患者 LOGISTIC回归
  • 简介:Objective:MemorystemTcells(Tscm)haveattractedattentionbecauseoftheirenhancedself-renewal,multipotentcapacity,andanti-tumorcapacities.However,littleisknownaboutTscminpatientswithrenalclearcellcarcinoma(RCC)andtheroleofWntsignalinginthesecells.WeevaluatedTscmfromRCCpatientsconcerningtheiractivationofWntsignalinginvitroandexploredthemechanismofpreferentialsurvival.Methods:FlowcytometryidentifiedsurfacemarkersandcytokinesproducedfromaccumulatedTscminthepresenceoftheglycogensynthasekinasebetainhibitorTWS119.Apoptosiswasevaluatedafterinductionusingtumornecrosisfactor-alpha.ImmunofluorescenceandWesternblotanalyseswereusedtoinvestigatetheactivationofthenuclearfactor-kappaB(NF-КB)pathway.Results:RCCpatientshadasimilarpercentageofCD4~+andCD8~+Tscmashealthydonors.ActivationofWntsignalingbyTWS119resultedintheaccumulationofTscminactivatedTcells,butreversalofdifferentiatedTcellstoTscmwasnotachieved.PreferentialsurvivalofTscmwasassociatedwithincreasedanti-apoptoticabilitymediateddownstreamoftheNF-КBactivationpathway.Conclusions:ThefindingthatTscmcanaccumulatebyWntsignalinginvitroinbloodfromRCCpatientswillhelpindevisingnewcancertherapystrategiesofTscm-basedadoptiveimmunotherapy,suchasdendriticcell-stimulatedTscm,andTcellreceptororchimericantigenreceptor-engineeredTscm.

  • 标签: MEMORY STEM T cell TWS119 WNT
  • 简介:Myeloidsarcoma(MS)isararehematologicalneoplasmthatdevelopseitherdenovoorconcurrentlywithacutemyeloidleukemia(AML).ThisneoplasmcanalsobeaninitialmanifestationofrelapseinapreviouslytreatedAMLthatisinremission.A44-year-oldmalepatientwasdiagnosedwithtestisMSinalocalhospitalinAugust2010.Afteronemonth,bonemarrowbiopsyandaspirationconfirmedthediagnosisofAML.Allogeneicmobilizationperipheralbloodstemcelltransplantationwasperformed,withthesisterofthepatientasdonor,aftercompleteremission(CR)wasachievedbychemotherapy.Fivemonthsaftertreatment,anadrenalmasswasdetectedbypositronemissiontomography-computedtomography(PET-CT).Radiotherapywasperformedforthelocalizedmassafteramultidisciplinaryteam(MDT)discussion.ThepatientisstillaliveasofMay2013,withnoevidenceofrecurrentMSorleukemia.

  • 标签: 造血干细胞移植 白血病 外周血 肾上腺 急性 肉瘤
  • 简介:AJNR,2008Jun26.BACKGROUNDANDPURPOSE:InclusionofoligodendroglialtumorsmayconfoundtheutilityofMRbasedgliomagrad-ing.Ouraimwas,first,toassessretrospectivelywhetherahistogram-analysismethodofMRperfusionimagesmaybothgrade

  • 标签: 大脑 血管 医学图象 神经胶质瘤 诊断方法