简介：Theearlydiagnosisofcardiacruptureisoneofthekeyfactorsforasuccessfuloutcome.However,theaccuratediagnosisisoftendifficultintheearlystageofinjury,especiallywhensomeobviousseverewoundsarefoundinotherregionsofthebody,1,2fortheyareeasytodisguisethesymptomoftheheart.Wereportacasewithcardiacruptureandlivertraumacausedbytrafficaccident.

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简介：ＩＤｅｐａｒｔｍｅｎｔｏｆＰａｔｈｏｌｏｇｙ，ＴｈｉｒｄＭｉｌｉｔａｒｙＭｅｄｉｃａｌＵｎｉｖｅｒｓｉｔｙ，Ｃｈｏｎｇｑｉｎｇ４０００３８，Ｃｈｉｎａ（ＷａｎｇＸＤ，ＬｉｕＹＳａｎｄＦｅｎｇＪＭ）ｔｉｓｒｅｐｏｒｔｅｄｔｈａｔＴＮＦαｉｓｔｈｅｉ...

简介：Objective:ToinvestigatetheeffectsofCO2pneumo-peritoneumonbloodflowvolumeofabdominalorgansofrabbitswithcontrolledhemorrhagicshockmodelandliverimpactinjuries.Methods:Aftercontrolledhemorrhagicshockandliverimpactinjuries,therabbitmodelwasestablished.Eighteenrabbitssubjectedtohemorrhagicshockandliverimpactinju-riesweredividedinto3groupsrandomlyaccordingtothevolumeoflostblood:lighthemorrhagicshock(bloodlossvolumewas10%,6ml/kg),moderatehemorrhagicshock(20%,12ml/kg)andseverehemorrhagicshock(40%,22ml/kg).IntraabdominalpressuresofCO2pneumoperitoneumwas10mmHg.Color-labeledmicrosphereswereusedtomea-surethebloodflowvolumeoftheliver,kidneyandstomachbeforepneumoperitoneumat30minutesand2hoursafterpneumoperitoneumand30minutesafterdeflation.Andthemortalityandhepatictraumaticconditionofrabbitswererecorded.Results:Ofthe18rabbits,therewere9withliverimpactinjuriesatGradeⅠ,8atGradeⅡandⅠatGradeⅢ(accordingtoAIS-2005).Themortalityrateinlighthemorrhagicshockgroupwas33.33%,andthatinmoderateorseverehemor-rhagicshockgroupwas100%within30minutesand2hoursafterpneumoperitoneum,respectively.Thebloodflowvol-umeintheorgansdetecteddecreasedat30minutesunderpneumoperitoneuminlightandmoderatehemorrhagicshockgroups.Atthesametime,thebloodflowvolumeoftheliverinmoderatehemorrhagicshockgroupdecreasedmoresig-nificantlythanthatinlighthemorrhagicshockgroup.Conclusions:ThebloodflowvolumeofabdominalorgansinrabbitsisdecreasedobviouslyunderCO2pneumoperitoneum,withfairlyhighmortalityrate.Itisbe-lievedthatCO2pneumoperitoneumshouldcautiouslybeusedinabdominalinjuryaccompaniedwithhemorrhagicshock,especiallyundernon-resuscitationconditions.

简介：Objective:Toinvestigatetheexpressionandpatternofvascularendothelialgrowthfactor(VEGF)anditsfetalliverkinase-1(Flk-1)receptorinspinalcordanddorsalrootgangliaafterneurotomyofsciaticnerveinrats.Methods:Forty-fiveadultmaleWistarratsweredividedrandomlyintoacontrolgroup(n=5)andanexperimentalgroup(n=40).ThebilateralsciaticnervesoftheratsintheexperimentalgroupunderwentneurotomyandtheL4-L6spinalcordandthecorrespondingdorsalrootgangliawereharvestedrespectivelyat8hours,and1,3,5,7,10,14and21days(8subgroupswith5ratseach)afteroperation.Theratsinthecontrolgrouponlyunderwentanexposureofsciaticnervewithoutneurotomy.ImmunohistochemistryandimageanalysiswereusedtostudytheexpressionofVEGFanditsFlk-1receptor.Results:BothVEGFandFlk-1receptorexpressedinthenormalratspinalcordanddorsalrootganglia.Inresponsetoneurotomy,theirexpressionreachedahigherlevelandpersistedforashorttimethendeclinedtothenormallevelrapidly.Besides,positivestainingofFlk-1wasobservedinbothglialcellsandnervefibers,whichlocatedinthewhitematterofthespinalcord.Conclusions:VEGFcanpromotetheregenerationofperipheralnervesfromtheangleofcentralneurons,whichestablishestheexperimentalandtheoreticalfoundationforVEGFtreatingperipheralnerveinjuries.