TEMPERATURE RESPONSIVE METHACRYLAMIDE POLYMERS WITH ANTIBACTERIAL ACTIVITY

(整期优先)网络出版时间:2010-04-14
/ 1
Anewmethacrylamidemonomer,hexylaminemethacrylamide(MAHA),wassynthesizedandusedinpolymerizations.ThehomopolymerofMAHAanditscopolymersweresynthesizedbyfreeradicalpolymerizationtechniqueswithN-isopropylacrylamide(NIPAAm)intwodifferentcompositions.Thequaternizationofthehomopolymerandcopolymerswerecarriedoutusing1-bromopropane.ThecopolymerswithNIPAAmandalowMAHAcontentshowedtemperature-responsivebehaviorinanaqueousenvironment.Thelowercriticalsolutiontemperatures(LCSTs)ofthesepolymersvariedbetween32℃and44℃.TheLCSTsofquaternizedcopolymerswerehigherthanthoseofneutralcopolymersbecausetheyweremorehydrophilic.TheobtainedhomopolymersandcopolymersweretestedforantibacterialactivitiesagainstS.aureusandE.coli.Thequaternizedwater-solublecopolymersshowedantibacterialactivitiesagainstS.aureus.Thequaternizationresultedinthesynthesisofbothantibacterialandtemperature-responsivecopolymers.