Inanefforttodevelopbiomaterialstomeetguidedtissueregeneration(GTR)standardsforperiodontaltissuerecovery,ahomogeneousandtransparentchitosan(CS)/hydroxyapatite(HA)membranewithpotentialapplicationsasGTRbarrierinperiodontaltherapyhasbeenpreparedviainsitucompositing.ThemembranehasbeendesignedtohaveasmoothroughasymmetricstructurethatmeetsthedemandforGTR.ComponentandmorphologyofthemembranearecharacterizedbyXRDandSEM.ItcanbeindicatedthatHAwasinsitusynthesizeduniformlyintheCSmembrane.MechanicalexperimentsofthemembraneswithvariousHAcontentsshowthattheirtensilestrengthsareadequateforperiodontaltherapy.Biologicalpropertiesofthemembranehavebeenperformedbycelltoxicityassays,hemolysistestsandanimalexperiments.Resultsindicatethatthemembranehasgoodbiocompatibilityandinductiveeffectforcellgrowth.ThereforethismembranecanbepotentiallyappliedasGTRbarriermembraneforperiodontaltissueregeneration.
