Objective:Tostudytheroleofmonocytesinthepathogenesisofgenitalherpes.Methods:TNF-aandIL-6levelsin27casesofgenitalherpesweredetectedbyenzymelinkedimmunosorbantassay(ELISA).HLAclassⅡantigenexpressiononmonocytesweredetectedbyanalkalinephosphataseanti-alkalinephosphatasemethod.Results:Comparedwithnormalcontrols,levelsofTNF-aandIL-6secretedbymonocytesrespondingtoLPSmitogeninvitroweresignificantlydecreased[(3.13±0.44ng/ml)vs(4.68±0.54ng/ml),P<0.05and(3.32±1.06ng/ml)vs(6.46±1.94ng/ml),P<0.05,respectively].HLAclassⅡantigenexpressiononmonocytesinthegenitalherpesgroupwasalsosignificantlydecreased[HLA-DR(67.48%±1.51%)vs(81.03%±1.32%),P<0.01andHLA-DQ(29.54%±1.15%)vs(37.63%±1.79%),P<0.01respectively].Conclusion:Thesefindingssuggestthatthedecreasedmonocytefunctionmaycontributetothepathogenesisofgenitalherpes.Augmentingorinducingmonocytefunctionmaybeimportantintheprevention,treatment,andreductionofgenitalherpescases.
