Intheprocessofoxidativephosphorylation,protonsarepumpedintotheintermembranespacetoestablishthemitochondrialmembranepotential(MMP).Relyingontheelectrochemicalgradient,protonscanreturntothematrixthroughtheATPsynthasecomplexwithATPgeneration.MitoQ,alipophiliccationdrug,canbebsorbedtotheinnermitochondrialmembranewiththecationicmoietystayingattheintermembranespace[1].