Brainmicrovascularendothelialcellsformtheinterfacebetweennervoustissueandcirculatingblood,andregulatecentralnervoussystemhomeostasis.Brainmicrovascularendothelialcellsdifferfromperipheralendothelialcellswithregardsexpressionofspecificiontransportersandreceptors,andcontainfewerfenestrationsandpinocytoticvesicles.Brainmicrovascularendothelialcellsalsosynthesizeseveralfactorsthatinfluencebloodvesselfunction.Thisreviewdescribesthemorphologicalcharacteristicsandfunctionsofbrainmicrovascularendothelialcells,andsummarizescurrentknowledgeregardingchangesinbrainmicrovascularendothelialcellsduringstrokeprogressionandtherapies.Futurestudiesshouldfocusonidentifyingmechanismsunderlyingsuchchangesanddevelopingpossibleneuroprotectivetherapeuticinterventions.