Ultrasoundsimulationforcarotidarteriesishelpfultotheperformanceassessmentsofvesselwalldetectionandsignalprocessingmethodsbyusingultrasoundtechniques.Anultrasoundsimulationmethodofcarotidarterywallwithathree-membranestructureisproposedinpresentstudy.Accordingtotheultrasoundspeckledistributionsvaryingwiththeshapesanddensitiesofscattererdistributions,aswellasthestatisticresultsoftheclinicalimages,theparametersofdistributions,densitiesandintensitiesofscatterersfordifferentkindsoftissuesinthecarotidarteryphantomsaredetermined.EachregionisacousticallycharacterizedusingFIELDIIsoftwaretoproducetheradiofrequencyechosignals,fromwhichultrasoundimagesarederived.Theresultsbasedon30simulationsshowthattheechodistributionsoftheintimae,mediae,adventitiasandbloodareconsistentwiththeclinicalones.Moreover,comparedwiththeresultsfromthecentralfrequencyof8MHz,themeanmeasurementsforthicknessesoftheintima,mediaandadventitiamembranes,aswellasthelumendiameterfromthesimulationimagesbasedon12MHzarethesameasthepresetones,andthemaximumrelativeerrorsarethe4.01%,1.25%,0.04%and0.15%,respectively.Thesimulationunderthisconditionismorerealistic.