摘要
Anacousticbasedinstrument,theABSAcousticBubbleSpectrometer??(ABS),wasinvestigatedforthedetectionandquantificationofbubblesinbiologicalmedia.Theseincludeviscoelasticmedia(blood),materialsofvaryingdensity(boneintissue),non-homogenousdistributionofbubbles(intravenousbubblyflow),andbubblesmigratingintissue(decompressionsickness,DCS).TheperformanceoftheABSwasdemonstratedinaseriesoflaboratoryexperiments.Validationofthecodewasperformedusingaviscoelasticpolymersolution,Polyox,inwhichthebubblesizedistributionandvoidfractionweredeterminedbyABSmeasurementsandwithimageanalysisofhighspeedvideos.ThesetestsshowedthattheaccuracyoftheABSwasnotsignificantlyaffectedbyviscoelasticityforbubblessmallerthan200microns.TheABSdetectionandmeasurementofnon-homogenousbubbledistributionswasdemonstratedusingabubblyflowthroughasimulatedveinsurroundedbytissue.Thescatterofacousticsignalsduetobonesintheacousticpathwaywasalsoinvestigated.Thesein-vitroexperimentsweredoneusingmeat(beef)asatissuesimulant.Decompressionexperimentsweredoneusingbeefmeatwhichwasheldunderwaterathighpressure(9.9atm)thenrapidlydecompressed.Bubblesizedistributionsandvoidfractioncalculationsintheseexperimentswerethenvalidatedusingimageanalysisofhighspeedvideo.Inaddition,preliminaryexperimentswereperformedwiththeUSNavyMedicalResearchCenter,demonstratingtheutilityofthemodifiedABSsystemindetectingtheevolutionofbubblesinswineundergoingdecompressionsickness(DCS).TheseresultsindicatethattheABSmaybeusedtodetectandquantifytheevolutionofbubblesin-vivoandaidinthemonitoringofDCS.
出版日期
2009年01月11日（中国期刊网平台首次上网日期，不代表论文的发表时间）
