摘要
摘要目的探讨抗栓治疗与CMBs及缺血性脑卒中后脑出血转化(HT)的关系.方法选择１２７例急性缺血性脑卒中患者,入院３天内均行SWI序列检查,将患者分为CMBs阳性组和阴性组,记录CMBs发生例数、病灶部位、数目,记录患者的性别及年龄、病史及口服抗栓药物情况.所有患者入院后根据个体化原则予以抗血小板或抗凝治疗.治疗后２周复查SWI及CT.观察两组患者CMBs的总数、部位有无变化,有无HT.结果抗栓治疗与CMBs的发生无明显相关(P＞０．０５),合并CMBs的抗血小板治疗患者(１０．４％)与抗凝治疗患者(１４．３％)相比差异无显著性(χ２＝０．３２４,P＝０．５６９).抗栓治疗２周后CMBs阳性组的CMB部位、总数与入院时比较差异无统计学意义(P＞０．０５),CMBs阴性组未发现新的CMBs.CMBs阳性组发生HT３例(８．８２％),CMBs阳性组发生HT８例(８．６０％),两组比较差异无统计学意义(χ２＝０．００２,P＝０．９６９).结论抗栓治疗与CMBs的发生及HT无关.关键词脑微出血;缺血性脑卒中;出血转化;抗栓治疗AbstractObjectivTostudytherelationshipabouttheantithrombotictherapywithcerebralmicrobleedsandpost－ischemicstrokehemorrhagictransforＧmation(HT)．MethodsToselect１２７casesofacuteischemicstrokepatients,SWIsequencewasperformedwithin３daysafteradmission,thepatientsweredividedintoCMBspositivegroupandnegativegroup．ThenumberofCMBs,thelocationandnumberoflesionswererecorded．Thesexandageofpatientsandthehistoryofthepatientsandtheoraldrugresistancewererecorded．Afteradmission,allpatientsweretreatedwithantiplateletoranticoagulanttherapyaccordingtotheprincipleofindividualization．２weeksaftertreatment,SWIandCTwerereviewed．ThetotalnumberandlocationofCMBsandwhetherornotHTinthetwogroupswereobserved．ResultsAntithrombotictherapyandtheincidenceofCMBShadnosignificantlycorrelated(P＞０．０５)．Therewasnosignificantdifferenceintheantiplatelettherapypatients(１０．４％)andanticoagulationtherapypatients(１４．３％)(χ２＝０．３２４,P＝０．５６９)．TherewasnosignificantdifferenceinthenumＧberofCMBsitesandthetotalnumberofCMBspositivegroup(P＞０．０５)after２weeksoftreatment,andthenewCMBswasnotfoundinCMBsnegativegroup．IntheCMBSpositivegroup,３caseswereHT(８．８２％),IntheCMBSpositivegroup,８caseswereoccurred(８．６０％)．ThedifferencebetweenthetwogroupswasnostatKisetyicwalorsdigsnificance(χ２＝０．００２,P＝０．９６９)．ConclusionTheantithrombotictherapyisnotassociatedwiththeoccurrenceofCMBsandHT．Cerebralmicrobleeds;Ischemicstroke;Hemorrhagictransformation;Antithrombotictherapy中图分类号R７４３．３文献标识码B文章编号１００１－５３０２(２０１５)０９－０６５８－０２
出版日期
2015年09月19日（中国期刊网平台首次上网日期，不代表论文的发表时间）
