Molecular Phylogenetics and Functional Evolution of Major RNA Recognition Domains of Recently Cloned and Characterized Autoimmune RNA-Binding Particle-中国期刊网

摘要 Heterogeneousnuclearribonucleoproteins(hnRNPs)arespliceosomalmacromolecularassemblagesandthusactivelyparticipateinpre-mRNAmetabolism.Theyarecomposedofevolutionarilyconservedandtandemlyrepeatedmotifs,wherebothRNA-bindingandprotein-proteinrecognitionoccurtoachievecellularactivities.Byyetunknownmechanisms,theseribonucleoprotein(RNP)particlesaretargetedbyautoantibodiesandhenceplaysignificantroleinavarietyofhumansystemicautoimmunediseases.Thisfeaturemakesthemimportantprognosticmarkersintermsofmolecularepidemiologyandpathogenesisofautoimmunity.SinceRNPdomainisoneofthemostconservedandwidespreadscaffolds,evolutionalysesoftheseRNA-bindingdomainscanprovidefurthercluesondisease-specificepitopeformation.ThestudypresentedhereinrepresentsasequencecomparisonofRNA-recognitionregionsofrecentlyclonedandcharacterizedhumanhnRNPA3withthoseofotherrelevanthnRNPA/B-typeproteins.Theirimplicationsinhumanautoimmunityareparticularlyemphasized.

1HUI JUN ZHOU;XIAO PING YANG;WAN SHENG CHEN;PETER ROBERTS THOMSON;HU JI XU. A functional study of low molecular weight IgM from patients with autoimmune disease.基础医学,2006-03.
2Xian-Zi Wen;Zhi-Hai Chen;Ya-Zhi Wei;Jia-Fu Ji. Evolution of viral RNA in a Chinese patient to interferon/ribavirin therapy for hepatitis C.肿瘤,2012-04.
3王燕;董顺乐. Molecular dynamics study of ice structural evolution.物理,2008-06.
4邓小莉. RNA干涉技术.高等教育学,2005-03.
5Ding-ding Hu;Shi-bing Ye;Fei Yu;Jia-chun Feng. Further Understanding on the Three Domains of Isotactic Polypropylene by Investigating the Crystalline Morphologies Evolution after Treatment at Different Domains.高分子化学,2016-03.
6Zhang Xing-Xing,Chen Hua,Li Hui-Ying,Chen Rui,He Lei,Yang Juan-Li,Xiao Lin-Lin,Chen Jin-Lian. Long non-coding RNA small nucleolar RNA host gene 6 aggravates pancreatic cancer through upregulation of far upstream element binding protein 1 by sponging microRNA-26a-5p.医药卫生,2020-08.
7Thierry K. S. Janssens Dick Roelofs Nico M. van Straalen. Molecular mechanisms of heavy metal tolerance and evolution in invertebrates.昆虫学,2009-01.
8Li Xue-Wei,Yang Wen-Hui,Xu Jun. Circular RNA in gastric cancer.医药卫生,2020-08.
9王晓刚,童钟,宇汝胜,刘永庆,刘庆元,胡启立. 肝细胞癌患者血清中微小RNA-432、微小RNA-30b、微小RNA-764水平.医药卫生,2020-11.
10Tian-Luu Wu. Recognition of Shapes for Object Retrieval in Image Databases by Discrete Curve Evolution.计算机应用技术,2010-11.

Molecular Phylogenetics and Functional Evolution of Major RNA Recognition Domains of Recently Cloned and Characterized Autoimmune RNA-Binding Particle

来源期刊

相关推荐

同分类资源更多

相关关键词

Molecular Phylogenetics and Functional Evolution of Major RNA Recognition Domains of Recently Cloned and Characterized Autoimmune RNA-Binding Particle

来源期刊

相关推荐

同分类资源 更多

相关关键词

同分类资源更多