Ohmefentanyl stereoisomers induce changes of CREB phosphorylation in hippocampus of mice in conditioned place preference paradigm-中国期刊网

摘要 ThepresentstudywasdesignedtodeterminethechangesofphosphorylationofcAMP-responseele-mentbindingprotein(CREB)inhippocampusinducedbyohmefentanylstereoisomers(F9202andF9204)inconditionedplacepreference(CPP)paradigm.TheresultsshowedthatmicereceivingF9202andF9204displayedobviousCPP.TheycouldallsignificantlystimulateCREBphosphorylationandmaintainedforalongtimewithoutaffectingtotalCREBproteinlevels.TheeffectofF9204wassimilartomorphinewhicheffectwasmorepotentandlongerthanF9202.Wealsoexaminedtheeffectsofketamine,anoncompetitiveN-mthyl-D-aspartatereceptor(NR)antagonist,onmorphine-,F9202-andF9204-inducedCPPandphos-phorylationofCREBinhippocampus.KetaminecouldsuppressnotonlytheplacepreferencebutalsothephosphorylationofCREBproducedbymorphine,F9202andF9204.ThesefindingssuggestthatalterationsinthephosphorylationofCREBberelevanttoopiatessignalingandthedevelopmentofopiatesdependence.NRantagonistsmayinterferewithopiatesdependenceandmayhavepotentialtherapeuticimplications.

1Gong Ying - Xia;Wang Hui - Juan;Zhu Yong - Ping;Chen Zhong. Effects of carnosine on morphine- induced conditioned place preference in Sprague -Dawley rats.药学,2006-04.
2Richard Justin Garling;Lora Talley Watts;Shane Sprague;Lauren Fletcher;David F.Jimenez;Murat Digicaylioglu. Does progesterone show neuroprotective effects on traumatic brain injury through increasing phosphorylation of Akt in the hippocampus？.神经病学与精神病学,2014-12.
3刘燕;鲍锦华;等. Structural changes of neurons in hippocampus from infantile rats exposed to hyperbaric oxygen.临床医学,2000-04.
4Huiqing Xie;Jianda Zhou;Shaodan Sun;Xuhong Li;Liming Deng;Fengmei Li. Dynamic changes of beta-amyloid protein deposition in hippocampus of female ovariectomized rats.神经病学与精神病学,2008-01.
5Jin Xiaodong;Li Feifei;Li Qiang. 3-49 Carbon Ions Induce Autophagy Effectively through Stimulating the Unfolded Protein Response and Subsequent Inhibiting Akt Phosphorylation in Tumor Cells.物理,2015-01.
6Chen Ning,Zhang Jian-Guo,Han Chun-Lei,Meng Fan-Gang. Hippocampus chronic deep brain stimulation induces reversible transcript changes in a macaque model of mesial temporal lobe epilepsy.医药卫生,2021-08.
7LICUNHANG;WURONG. CONDITIONED SUPERPROCESSES.基础数学,1997-02.
8赵文彬. Preference.教育学,2009-10.
9赵文彬. Expressing Preference.教育学,2009-07.
10王强;王元和;高瀚;陈咏莲;何金. QUALITATIVE　STUDY　OF　SIALOMUCINS　CHANGES　DURING　N－METHYL－N－NITROSOUREA－INDUCED　C　OLONIC　CARCINOGENESIS　IN　MICE.肿瘤,1994-04.

Ohmefentanyl stereoisomers induce changes of CREB phosphorylation in hippocampus of mice in conditioned place preference paradigm

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Ohmefentanyl stereoisomers induce changes of CREB phosphorylation in hippocampus of mice in conditioned place preference paradigm

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