Advances in isolation and detection of circulating tumor cells based on microfluidics-中国期刊网

摘要 Circulatingtumorcells(CTCs)arethecancercellsthatcirculateintheperipheralbloodafterescapingfromtheoriginalormetastatictumors.CTCscouldbeusedasnon-invasivesourceofclinicalinformationinearlydiagnosisofcancerandevaluationofcancerdevelopment.Inrecentyears,CTCresearchhasbecomeahotspotfieldwhereinmanynovelCTCdetectiontechnologiesbasedonmicrofluidicshavebeendeveloped.Greatadvanceshavebeenmadethatexhibitobvioustechnicaladvantages,butcannotyetsatisfythecurrentclinicalrequirements.Inthisstudy,wereviewthemainadvancesinisolationanddetectionmethodsofCTCbasedonmicrofluidicsresearchoverseveralyears,proposefivetechnicalindicatorsforevaluatingthesemethods,andexploretheapplicationprospects.Wealsodiscusstheconcepts,issues,approaches,advantages,limitations,andchallengeswithanaimofstimulatingabroaderinterestindevelopingmicrofluidics-basedCTCdetectiontechnology.

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Advances in isolation and detection of circulating tumor cells based on microfluidics

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Advances in isolation and detection of circulating tumor cells based on microfluidics

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