摘要
InordertoanalyzethemechanismofimmunomodulationbyLPSonmurineperitonealsuppressormacrophages,wehave,usingRNaseprotectionassay,checkedthechangesofmRNAexpressionpatternofseveralcytokinegenesduringtheimmuno-modulation.Ithasbeenfoundthat,aftertreatingperitonealsuppressormacrophageswithLPS,mRNAsofIL-12p35,IL-12p40,IL-6andIFN-γarenewlyappeared,whilethoseofIL-1α，IL-1βandIL-1Raareincreasebandthoseofothercytokines,likeTGF-β1andMIFarenotchangedatall.Itseemscertainthatthosecytokines,whoseexpressionisincreasedbyLPSstimulation,mayberesponsibleforthefunctionalchangesofsuppressormacrophagesduringimmuno-modulation.Amongthesechanges,theappearanceofIL-12mRNAmayplayacriticalrole,and,inthisregard,thesynergeticeffectbetewwnIFN-γandLPSontheincreaseofIL-12p35andIL-12p40mRNAexpressionisaninterestingfinding.
出版日期
1998年04月14日（中国期刊网平台首次上网日期，不代表论文的发表时间）
