The involvement of p38 MAPK in transforming growth factor β1－induced apoptosis in murine hepatocytes-中国期刊网

摘要 WereportedinthismanuscriptthatTGF-β1inducesapoptosisinAML12murinehepatocytes,whichisassociatedwiththeactivationofp38MAPKsignalingpathway.SB202190,aspecificinhibitorofp38MAPK,stronglyinhibitedtheTGF-β1-inducedapoptosisandPAI-1promoteractivity.TreatmentofcellswithTGF-β1activatesp38.Furthermore,over-expressionofdominantnegativemutantp38alsoreducedtheTGF-β1-inducedapoptosis.Thedataindicatethattheactivationofp38isinvolvedinTGF-β1-mediatedgeneexpressionandapoptosis.

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The involvement of p38 MAPK in transforming growth factor β1－induced apoptosis in murine hepatocytes

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The involvement of p38 MAPK in transforming growth factor β1－induced apoptosis in murine hepatocytes

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