摘要
Objective:Thisstudyaimstoexploretheclinicopathologiccharacteristicsandprognosticfactorsofgastriccancerpatientswithmetachronousovarianmetastasis.Methods:Clinicopathologicdatawerecollectedfrom63post-operativegastriccancerpatientswithmetachronousovarianmetastasis.ThepatientswereadmittedtotheCancerInstituteandHospital,ChineseAcademyofMedicalScienceandPekingUnionMedicalCollegebetweenJanuary1999andDecember2011.Alog-ranktestwasconductedforsurvivalanalysis.Possibleprognosticfactorsthataffectsurvivalwereexaminedbyunivariateanalysis.ACoxregressionmodelwasusedformultivariateanalysis.Results:Theincidenceofovarianmetastasiswas3.4%withameanageof45years.Upto65.1%ofthepatientswerepre-menopausal.Themeanintervalbetweenovarianmetastasisandprimarycancerwas16months.Lowlydifferentiatedcarcinomarankedfirstintheprimarygastriccancers.Themajorityoflesionsoccurredintheserousmembrane(87.3%).ThemetastaticsitesincludedN2-3lymphnodes(68.3%),bilateralovaries(85.7%),andperitonealmembrane(73%).Totalresectionofmetastaticsiteswasperformed(31.7%).Theoverallmediansurvivalwas13.6months,whereastheoverall1-,2-,and3-yearsurvivalrateswere52.5%,22.0%,and9.8%,respectively.The5-yearsurvivalratewaszero.Univariateanalysisshowedthatthepatientprognosiswascorrelatedwithmetastaticperitonealseeding,vasculartumorembolus,rangeoflesionexcision,andmodeofcomprehensivetreatmentwithadjuvantchemotherapy(P<0.05).Multivariateanalysisindicatedthatmetastaticperitonealseedingwasanindependentprognosticfactorforgastriccancerpatientswithovarianmetastasis(P<0.01).Conclusion:Effectivecontrolofperitonealseeding-inducedmetastasisisimportantforimprovingtheprognosisofgastriccancerpatientswithovarianmetastasis.
出版日期
2013年02月12日（中国期刊网平台首次上网日期，不代表论文的发表时间）
