简介:Themostimportantriskfactorforstrokeandneurodegenerationisaging.Infact,survivalafterstrokediminisheslargelywithaging.Infact,recoveryafterbrainarteryocclusionisdramaticallyworsenedbyaging,evennormalagingisassociatedwithneurondamageandcognitivedecline.Mechanismsinvolvedinaging-related,cognitivedeclineandsusceptibilitytoneurondamageinstrokeandneurodegenerationarelargelyunknown.Oneofthemostimportant
简介:Thecurrentstudydemonstratedthatinjuryofthespinalcordlateralfuniculusoccursinlivercirrhosis.Thisstudysoughttocomparethemorphologyofthethoracicandlumbarcord,theexpressionoffunctionalproteins,andchangesinvesselsbetweenlivercirrhosisandnon-cirrhosiscorpses.Resultsshowedthatinthelivercirrhosisgroup,thehepaticveinexpanded,thegastrointestinaltractwasfullofcoagulatedblood,blood-stasiswaseasilyseenintheveniplexofthevertebralcanalandthelumbarspinalcord,andthecellbodiesoftheanteriorhorninthethoracicandlumbarcordweresmallerthanthoseinnon-cirrhosiscorpses.Inaddition,nervecellsshrank,Nisslbodieswereconcentratedwithobscurednuclei,andneurofilamentandsynapsincontainingcellbodiesoftheanteriorhornandwhitematterdecreasedinthelivercirrhosisgroup.Theseexperimentalfindingsindicatethatabnormalcirculationofthespinalcord,resultingfromhemodynamicchangeofcirrhoticportalhypertension,maybethemostsignificantcauseofhepaticmyelopathy.