简介：【摘要】：目的 观察分析聚乙二醇干扰素α-2a联合恩替卡韦治疗乙型病毒性肝炎患者的临床效果。方法 选取我院2018年1月-2019年10月收治的HBeAg阳性慢性乙型肝炎患者76例为本次的研究对象，随机将所有患者分为对照组与治疗组，每组患者各有38例。对照组患者采用聚乙二醇干扰素治疗，治疗组患者在对照组治疗措施的基础上采用恩替卡韦治疗。比较两组患者的的临床疗效，检测并比较治疗前及治疗1 年后两组患者的肝功能指标水平变化。结果 治疗组患者的临床治疗总有效率为92.11%，明显高于对照组患者的73.68%（P

简介：

简介：　　【摘 要】目的：探究他克莫司与环磷酰胺治疗狼疮性肾炎的的效果和用药不良反应率。方法：纳入观察对象 40例（均确诊为狼疮性肾炎）进行实验研究，研究时间从 2015年 3月直至 2019年 5月。采用随机分组法，将观察对象分为甲乙两组，甲组 20例患儿使用他克莫司治疗，乙组 20例患儿采取环磷酰胺治疗。观察对比两组患儿治疗效果、不良反应发生情况。结果：甲组中 1例患儿疗效不明显，另外 19例均有改善，总有效率 95%;乙组中 5例疗效不明显， 1例病情恶化，另外 14例病情改善，总有效率 70%，两组间进行比较后得到 P<0.05。治疗后随访观察到，甲组患儿 1例出现尿痛的不良反应，乙组中有 6例，两组不良反应发生率的差异显著（ P<0.05）。结论：狼疮性肾炎患儿在治疗过程中可应用他克莫司与环磷酰胺进行治疗，对比发现，他克莫司可以明显提升治疗的有效率，并且控制了患儿不良反应的出现，治疗安全性得到保障，临床应用效果理想，值得推广。  　　【关键词】他克莫司 ;环磷酰胺 ;狼疮性肾炎 ;效果 ;不良反应率  　 [Abstract] Objective: To explore the effect and adverse reaction rate of tacrolimus and cyclophosphamide in the treatment of lupus nephritis. Methods: 40 patients (all diagnosed as lupus nephritis) were included in the experimental study. The study period was from March 2015 to may 2019. The observation objects were randomly divided into two groups, group A (20 cases) was treated with tacrolimus, and group B (20 cases) was treated with cyclophosphamide. The treatment effect and adverse reactions of the two groups were observed and compared. Results: in group A, the curative effect of 1 case was not obvious, the other 19 cases were improved, the total effective rate was 95%; in group B, the curative effect was not obvious in 5 cases, 1 case was deteriorated, the other 14 cases were improved, the total effective rate was 70%, the comparison between the two groups showed that P < 0.05. After treatment, 1 case of adverse reactions occurred in group A and 6 cases in group B. There was a significant difference in the incidence of adverse reactions between the two groups (P < 0.05). Conclusion: tacrolimus and cyclophosphamide can be used in the treatment of children with lupus nephritis. Compared with cyclophosphamide, tacrolimus can significantly improve the efficiency of treatment, and control the occurrence of adverse reactions in children. The safety of treatment is guaranteed and the clinical application effect is ideal, which is worthy of promotion.

简介：【摘要】目的  探讨他克莫司软膏治疗皮炎湿疹的疗效及对外周血Th1、Th2细胞因子水平的影响。方法  从收治的湿疹患者中选取72例作为研究对象，随机分组，各36例。其中对照组以糠酸莫米松软膏治疗，观察组以他克莫司软膏治疗。比较治疗疗效、不良反应。结果  观察组治疗总有效率高于对照组，差异显著（p＜0.05）。治疗后观察组Th1、Th2细胞因子指标水平优于对照组，差异显著（p＜0.05）。观察组不良反应发生率低于对照组，差异显著（p＜0.05）。结论  他克莫司软膏治疗皮炎湿疹的效果令人满意，可有效调节Th1/Th2细胞因子的平衡，并且具有较高的安全性。