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简介：BACKGROUND:Stellateganglionblock(SGB)playsaprotectiveroleonthebrain,buttheprecisemecha-nismofactionisnotclear.OBJECTIVE:TosimulateSGBbytransectionofthecervicalsympathetictrunk(TCST)andtoinvestigatetheTCSTeffectsonchangesincerebralinfarctvolumeandoxygenfreeradicallevelsinratswithfocalcere-bralischemia/reperfusioninjury.DESIGN,TIMEANDSETTING:AcompleterandomizedcontrolanimalexperimentwasperformedattheInstituteofNeurologicalDiseasesofTaiheHospital,YunyangMedicalCollegefromFebruarytoDecember2005.MATERIALS:Atotalof101healthyWistarrats,weighing280–320g,ofbothgenders,aged17–18weeks,wereusedinthisstudy.2,3,5-triphenyltetrazoliumchloride(TTC)waspurchasedfromChangshaHongyuanBiologicalCompany.Superoxidedismutase(SOD),malondialdehyde(MDA)andnitricoxide(NO)assaykitswereprovidedbyNanjingJianchengBioengineeringInstitute.METHODS:RatswererandomlydividedintoaTCSTgroup,amodelgroupandashamoperationgroup.Successfulmodelswereincludedinthefinalanalysis,withatleast20ratsineachgroup.AfterTCST,ratmodelsoffocalcerebralischemia/reperfusioninjurywereestablishedintheTCSTgroupbyreceivingmiddlecerebralarteryocclusion(MCAO)bytheintraluminalsuturemethodfor2hours,followedby24hoursofreperfusion.Ratmodelsoffocalcerebralischemia/reperfusioninjuryweremadeinthemodelgroup.Ratsintheshamoperationgroupunderwentexperimentalproceduresasforthemodelgroup,threadingdepthof10mm,andmiddlecerebralarterywasnotligated.MAINOUTCOMEMEASURES:BraintissuesectionsoftenratsfromeachgroupwereusedtomeasurecerebralinfarctvolumebyTTCstaining.BraintissuehomogenateofanothertenratsfromeachgroupwasusedtodetectSODactivities,MDAcontentsandNOlevels.Ratneurologicalfunctionwasassessedbyneu-robehavioralmeasures.RESULTS:CerebralinfarctvolumewasbiggerinthemodelgroupthanintheTCSTgr

简介：AJNR,2008Jun26.BACKGROUNDANDPURPOSE:InclusionofoligodendroglialtumorsmayconfoundtheutilityofMRbasedgliomagrad-ing.Ouraimwas,first,toassessretrospectivelywhetherahistogram-analysismethodofMRperfusionimagesmaybothgrade

简介：AbstractIntroduction:While majority of infants with bronchopulmonary dysplasia (BPD) can be discharged home without low flow oxygen or on supplemental low flow oxygen, some require long term home mechanical ventilation.Case presentation:We present a case of an extremely premature infant with severe bronchopulmonary dysplasia who was successfully managed at home on a new feature of non-invasive ventilation called average volume assured pressure support (AVAPS) without the need for tracheostomy. The AVAPS feature enables the machine to deliver a consistent tidal volume by automatically adjusting the inspiratory pressure within a set range.Conclusion:The use of AVAPS feature in our case improved ventilation as indicated by a more stable gas exchange profile, making home non-invasive ventilation a more practicable method of managing severe BPD in this infant.

简介：BackgroundLargepercutaneouscoronaryintervention(PCI)centershaveshownstatisticallybetterprognosiswithtransradialapproach(TRA)comparedwithtransfemoralapproach(TFA).SowetriedtocomparetheoutcomesbetweenTRAandTFAinonehighvolumePCIcenterinST-segmentelevationmyocardialinfarction(STEMI)patientsundergoingprimaryPCI.MethodSixhundredandsixtytwoSTEMIpatientswhounderwentprimaryPCIwithstentsimplantationwereretrospectivelyincludedfromJune1,2006toApril30,2011inourhospitalandprospectivelyfollowedforoneyear.Theprimaryendpointwasdefinedasin-hospitalnetadverseclinicalevents(NACE)whichincludeddeath,myocardialinfarction(MI),stroke,targetvesselrevascularization(TVR)andmajorbleeding.Thesecondaryendpointwasdefinedas1yearmajoradversecardiovascularevents(MACE)whichincludeddeath,MIandTVR.ResultsTheoccurrenceratesofNACE(8.0%vs.17.0%,P=0.0018),accesssitecomplications(4.0%vs.10.7%P=0.0027)andaccesssite-relatedmajorbleeding(2.4%vs.6.3%,P=0.0254)wereallhigherintheTFAgroupthanintheTRAgroup.Theincidencerateof1yearMACEwassimilarbetweenTRAandTFA(8.5%vs.13.2%,P=0.0932).TheinverseprobabilitiesweightingmatchedmultivariableCoxregressionanalysisshowedTRAwasanindependentpredictoroflowerratesofin-hospitalNACE(HR:0.58,95%CI:0.34-0.99,P=0.0477),in-hospitaldeath(HR:0.31,95%CI:0.10-0.73,P=0.0499)andaccesssitecomplications(HR:0.37,95%CI:0.19-0.73,P=0.0040).ConclusionsTRAshowedgreatefficacyandsafetyforSTEMIpatientsundergoingprimaryPCIinhighvolumePCIcenters.Itshouldberecommendedasroutinepracticeinfuture,andespeciallyinthosepatientswithhighriskofbleeding.

简介：Objective:Weinvestigatedthecorrelationbetweenthenumberofcirculatingtumorcells(CTCs)andwholebodymetabolictumorvolume(WBMTV)measuredby18F-fluorodeoxyglucose(FDG)positronemissiontomography/computedtomography(PET/CT).TheaimwastoevaluatethevalueoftheincorporationofCTCnumberandWBMTVintheprognosticpredictionofstageIIIsmall-celllungcancer(SCLC).Methods:Onehundredandtwenty-ninepatientswereenrolledinthisstudy.Allpatientsweretreatedwithfourcyclesofaplatinum-basedregimenandconcurrentchestirradiation,followedbyprophylacticcranialirradiation.BloodsamplesforCTCanalysiswereobtainedfrom112patientsbeforetheinitiationofchemotherapy(asabaseline),aftercycle1andaftercycle4.CTCsweremeasuredusingtheCELLSEARCH?system.ThepatientsunderwentpretreatmentFDGPET/CTWBMTV,whichincludedallmalignantlesions.TheSpearmanranktestwasusedtodeterminethecorrelationamongCTCcounts,WBMTVanddiseasestage.Overallsurvival(OS)andprogression-freesurvival(PFS)curveswereproducedusingtheKaplan-Meiermethod,andsurvivaldifferencesbetweengroupswereassessedbythelog-ranktest.Results:ThenumberofCTCsatbaselinedidnotcorrelatewithWBMTVbeforetheinitiationoftherapy(P=0.241).ThenumberofCTCsatbaselineandtheWBMTVbeforetheinitiationoftherapywereindependentrelevantfactorsforPFSandOS.Thesubgroupanalysis(GroupA:CTCcount>19.5andaWBMTV>266.5cm^3;GroupB:CTCcount>19.5andaWBMTV≤266.5cm^3;GroupC:CTCcount≤19.5andaWBMTV>266.5cm^3;GroupD:CTCcount≤19.5andaWBMTV≤266.5cm^3)showedthatthedifferenceswerestatisticallysignificantinthemedianPFS(GroupAvs.D,P<0.001;GroupBvs.D,P=0.018;GroupCvs.D,P=0.029)andinthemedianOS(GroupAvs.D,P<0.001;GroupBvs.D,P=0.012).Conclusions:CTCnumberandWBMTVarerelatedtoprogressionanddeathinpatientswithSCLC.TheincorporationofCTCnumberandWBMTVscanscanprovideadetailedprognosticpredictionforSCLC.