简介：Objective:Estimationofactivityaccumulatedintumorandorgansisveryimportantinpredictingtheresponseofradiopharmaceuticalstreatment.Inthisstudy,wesynthesized177Lutetium(177Lu)-trastuzumabironoxidenanoparticlesasadoubleradiopharmaceuticalagentfortreatmentandbetterestimationoforganactivityinanewwaybymagneticresonanceimaging（MRI）.Methods:177Lu-trastuzumab-ironoxidenanoparticlesweresynthesizedandallthequalitycontroltestssuchaslabelingyield,nanoparticlesizedetermination,stabilityinbufferandbloodserumupto4d,immunoreactivityandbiodistributioninnormalmiceweredetermined.Inmicebearingbreasttumor,liverandtumoractivitieswerecalculatedwiththreemethods:singlephotonemissioncomputedtomography（SPECT）,MRIandorganextraction,whichwerecomparedwitheachother.Results:Thegoodresultsofqualitycontroltests（labelingyield:61%±2%,meannanoparticlehydrodynamicsize:41±15nm,stabilityinbuffer:86%±5%,stabilityinbloodserum:80%±3%,immunoreactivity:80%±2%）indicatedthat177Lu-trastuzumab-ironoxidenanoparticlescouldbeusedasadoubleradiopharmaceuticalagentinmicebearingtumor.Resultsshowedthat177Lu-trastuzumab-ironoxidenanoparticleswithMRIhadtheabilitytomeasureorganactivitiesmoreaccuratethanSPECT.Conclusions:Co-conjugatingradiopharmaceuticaltoMRIcontrastagentssuchasironoxidenanoparticlesmaybeagoodwayforbetterdosimetryinnuclearmedicinetreatment.

简介：Objective:Lungcancerisoneoftheleadingcancersandmajorcausesofcancermortalityworldwide.Theeconomicburdenassociatedwiththehighmortalityoflungcancerishigh,whichaccountsfornearly$180billiononaglobalscalein2008.Thispaperaimstounderstandtheeconomicburdenoflungcancerintermsofdisabilityadjustedlifeyears(DALY)inAustralia,thePhilippines,andSingapore.Methods:Theyearsoflifelost(YLL)andyearslostduetodisability(YLD)werecalculatedusingtheformuladevelopedbyMurrayandLopezin1996aspartofacomprehensiveassessmentofmortalityanddisabilityfordiseases,injuriesandriskfactorsin1990andprojectedto2020.ThesameformulaisrepresentedintheGlobalBurdenofDiseasetemplateprovidedbytheWorldHealthOrganization.Appropriateassumptionsweremadewhendatawereunavailableandprojectionswereperformedusingregressionanalysistoobtaindatafor2015.Results:ThetotalDALYsduetolungcancerinAustralia,thePhilippines,andSingaporewere91,695,38,584,and12,435,respectively,andthecorrespondingDALYratesperapopulationof1,000were4.0,0.4,and2.2,respectively,withadiscountrateof3%.WhenresearcherscalculatedDALYswithoutthediscountrate,theburdenofdiseaseincreasedsubstantially;theDALYswere117,438inAustralia,50,977inthePhilippines,and16,379inSingapore.Overall,YLLorprematuredeathaccountedformorethan95%ofDALYsinthesecountries.Conclusions:Strategiesforprevention,earlydiagnosis,andprompttreatmentmustbedevisedfordiseaseswherethemajorburdenisduetomortality.