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简介：Objective:Toevaluatetheassociationbetweenobesityandtheriskofcolorectalcancer.Methods:331patientswithrectalcancerand175withcoloncancerwhoacceptedsurgicaloperationatBeijingCancerHospitalduring1995and2002wereenrolled.Datawerecollectedbyreviewingthepathologymaterialsandhospitalrecords.258healthypeoplewhoacceptedhealthexaminationatBeijingCancerHospitalduring2000and2002werealsoenrolledascontrol.Dataofheight,weightandgenderatthetimeofexaminationwerealsocollected.Obesitywasestimatedbybodymassindex(BMI),computedasweightinkilogramsdividedbyheightinmeterssquared(kg/m2).ThedegreeofobesitywascomparedbetweenthetwogroupsusingBMI(18.5,24-27.9and(28(kg/m2)asthecut-offpointsforunderweight,overweightandobesity.Associationswithobesitywereestimatedbyoddsratios(ORs)and95%confidenceintervals(CIs).AllORswereadjustedforageandsex.Results:Obesitywassignificantlyprevalentinfemalepatientswithrectalcancer.AllthepatientswithcoloncancershowedlowerlevelofBMIthancontrolsubjects.TheORsforrectalcancerrosewithincreasingBMIinwomen.Meanwhile,theORsforcoloncancerdroppedwithincreasingBMIinbothmenandwomen.Obesitywasanindependentriskfactorforrectalcancer,butnotanindependentriskfactorforcoloncancer.Conclusion:Rectalcancerandcoloncancermayhavedifferentbiologicalbehavior.Obesewomenhaverelativelyhighriskforrectalcancer.

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