简介:HippocampalvolumelossisanimportantbiomarkerindistinguishingsubjectswithAlzheimer’sdisease(AD)anditsmeasurementinmagneticresonanceimages(MRI)isinfluencedbypartialvolumeeffects(PVE).Thispaperdescribesapost-processingapproachtoquantifyPVEforcorrectionofthehippocampalvolumebyusingaspatialfuzzyC-means(SFCM)method.Thealgorithmisevaluatedonadatasetof20T1-weightedMRIscanssampledattwodifferentresolutions.Thecorrectedvolumesforleftandrighthippocampus(HC)whichare23%and18%forthelowresolutionand6%and5%forthehighresolutiondatasets,respectivelyarelowerthanhippocampalvolumeresultsfrommanualsegmentation.ResultsshowtheimportanceofapplyingthistechniqueinADdetectionwithlowresolutiondatasets.