简介：瞄准：为了建立老鼠乙醇胃炎，当模特儿，我们在胃的mucosa上评估了乙醇的效果并且在导致乙醇的长期的胃炎上学习了geranylgeranylacetone的预防效果。方法：100只男Sprague-Dawley老鼠随机被划分成4个相等的组：正常控制组，经历正常的胃的灌注盐(NS)由gastrogavage；为控制组和为4wk由gastrogavage与乙醇(有56%乙醇内容的精华精神)经历了胃的灌注的2个模型治疗组建模。geranylgeranylacetone的低或高的剂量被增加，在在2模型治疗的乙醇灌注前的1h组织NS的一样的数量，而不是geranylgeranylacetone在那个模型控制组被使用。老鼠然后被牺牲，胃被移开。胃的mucosa的损害水平被光和电子观察前列腺素2的显微镜学，和层次，endothelin-1(ET-1)和氮的氧化物(PGE2)(没有)被放射性免疫测定和Griess方法测量。结果：胃的mucosal表皮的损坏分数(版本；4.5)并且溃疡索引(UI；12.0)模型控制，组比正常控制组的显著地高级(0和0分别地，所有P=0.000)。胃的mucosal版本和2个模型治疗组的UI(版本：2.5和2.0；UI：3.5和3.0)比模型控制组的显著地低(所有P<0.01)。低剂量、高剂量的模型治疗组之间没有统计上重要的差别。模型控制组的血浆ET-1的表达式值比正常控制组的高(P<0.01)并且2个模型治疗组(所有P<0.01)。胃的mucosalPGE2和浆液的表示价值不模型控制组是比正常控制组的那些低的(所有P<0.05)并且2个模型治疗组(所有P<0.05)。胃的有粘液的layerand的厚度在模型控制组的hexosamine内容在正常控制组是比那显著地低的(所有P<0.01)并且2个模型治疗组(所有P<0.05)。扫描并且传播电子显微镜学观察在模型控制组，显示出那上皮的连接是含糊的，细胞间的关节消失了，细胞内部的细胞器的损坏是比在正常控制组的那些显著地更

简介：AIM:ToinvestigateapathophysiologicalroleofcathepsinW(CatW),aputativethiol-dependentcysteineprotease,whichisspecificallyexpressedincytotoxiclymphocytes,indifferenttypesofchronicinflammationofthegastricmucosa.METHODS:GastricandduodenalbiopsiesofpatientswithHelicobacterpylori(Hpylori)-associatedactivegastritis(Hp,n=19),chemicallyinducedreactivegastritis(CG,n=17),autoimmuneatrophicgastritis(AIG,n=20),lymphocyticcorpusgastritis(LG,n=29),celiacdisease(CD,n=10),andcorrespondingcontrols(n=24)wereanalyzedbyimmunohistochemistryfortheexpressionofCatWandCD45.Furthermore,immunohistochemicaldoublestainingwithanti-CD3andanti-cathepsinwasperformedforthesamplesofAIG.RESULTS:MedianvaluesofCatW-expressingcellsamongCD45-positiveimmunecellswerebetween2%and6%fornormalgastricmucosa,CG,andLG,whereasthecorrespondingvaluewassignificantlyincreasedforAIG(24.7%,P＜0.001)andsignificantlydecreasedforHP(0.7%,P＜0.05).Doublestainingwithanti-CD3andantiCatWantibodiesrevealedthat＞90%ofCatW-expressingcellsingastricmucosaofAIGwereTcells.DuodenalmucosahadsignificantlymoreCatW/CD45-positivecellsthannormalgastricmucosa(median:17.8%vs2%,P＜0.01).ThecorrespondingproportionofCatW/CD45-positivecellswasdecreasedinCDcomparedtoduodenalmucosa(median:2.1%vs17.8%,P＜0.05).CONCLUSION:TheoppositefindingsregardingthepresenceofCatW-positivecellsinAIG(increase)andCD(decrease)reflectsthedifferentcellularcompositionofimmunecellsinvolvedinthepathogenesisofthesediseases.

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简介：AIMToinvestigatetheinfluenceofprotonpumpinhibitors（PPIs）exposureonthediagnosisofHelicobacterpylori（H.pylori）gastritisandintestinalmetaplasia.METHODS：ChronicPPIuseisassociatedwithmaskingofH.pyloriinfection.PatientswithH.pyloriinfectionarepredisposedtogastricandduodenalulcers,andlong-terminfectionwiththisorganismhasbeenassociatedwithgastricmucosalatrophyandseriouslong-termcomplications,suchasgastriclymphomaandadenocarcinoma.ThreehundredpatientsdiagnosedwithgastritisbetweenJanuary2008andApril2010wereincludedinourstudy.Thecomputerizedmedicaldatabaseofthesepatientswasreviewedretrospectivelyinordertoassesswhetherthetypeofgastritisdiagnosed（H.pylorivsnon-H.pylorigastritis）isinfluencedbyPPIexposure.H.pyloridensitywasgradedaslow,ifcorrespondingtomilddensityfollowingtheUpdatedSydneySystem,orhigh,ifcorrespondingtomoderateorseveredensitiesintheUpdatedSydneySystem.RESULTS：Patientswereequallydistributedbetweenmalesandfemaleswithamedianageatthetimeofdiagnosisof50yearsold（range：20-87）.ThehistologicaltypesofgastritiswereclassifiedasH.pylorigastritis（n=156,52%）andnon-H.pylorigastritis（n=144,48%）.Allpatientswithnon-H.pylorigastritishadinactivechronicgastritis.PatientswithnopreviousPPIexposureweremorelikelytobediagnosedwithH.pylorigastritisthanthosewithpreviousPPIexposure（71%vs34.2%,P〈0.001）.Intestinalmetaplasiawasmorelikelytobedetectedinthelatterpatients（1.4%vs6.5%,P=0.023）.MultivariateanalysishasalsodemonstratedthatinthepresenceofpreviousPPIexposure（OR=0.217,95%CI：0.123-0.385）,GERD（OR=0.317,95%CI：0.132-0.763,P=0.01）,alcoholintake（OR=0.396,95%CI：0.195-0.804,P=0.01）,thedetectionofH.pyloriwaslesslikely.ChronicuseofPPIsmaymaskH.pyloriinfectionspromotingthediagnosisofnon-H.pylorigastritisandleadstoasi

简介：导致放射的胃炎是胃肠的流血的一个很少发生的原因。从放射治疗产生是严肃的复杂并发症的。起始的损害是胃的mucosa的表示特性地尖锐的发炎。我们介绍了一个46岁的男病人，出血性的胃炎为hepatocellular癌的变形retroperitoneal淋巴节点由外部放射疗法导致了。内视镜的考试在胃和十二指肠的灯泡的整个muscosa与毛细管扩张显示出弥漫的edematoushyperemicmucosa。有活跃流着的多重出血性的补丁在窦上被发现。反秘书治疗为hemostasis被开始，但是melena仍然发生了离开并且在上。最后，他被氢化尼松治疗成功地对待。我们强烈因此争论赞成perdnisolone治疗有效地与导致放射的出血性的胃炎对待病人。

简介：AIM:Toassessthemechanismsofprotectiveactionbydifferentmildirritantsthroughmaintenanceofgastricmucosalintegrityandmodulationofmucosalnitricoxide(NO)inexperimentalgastritisrats.METHODS:Etcher200mL/Lethanol,50g/LNaGor0.3mol/LHClwaspretreatedtonormalor800mL/Lethanol-inducedacutegastritisSprague-Dawleyratsbeforeasubsequentchallengewith500mL/Lethanol.Bothmacroscopiclesionareasandhistologicaldamagescoresweredeterminedinthegastricmucosaofeachgroupofanimals.Besides,gastricmucosalactivitiesofNOsynthaseisoformsandofsuperoxidedismutase,alongwithmucosallevelofleukotriene(LT)C4weremeasured.RESULTS:Macroscopicmucosaldamageswereprotectedby200mL/Lethanoland50g/LNaCIingastritisrats.However,although200mL/Lethanolcouldprotectthesurfacelayersofmucosalcellsinnormalanimals(protectionattenuatedbyNG-nitro-L-argininemethylester),nocytoprotectionagainstdeeperhistologicaldamageswasfoundingastritisrats.Besides,inducibleNOsynthaseactivitywasincreasedinthemucosaofgastritisanimalsandunalteredbymildirritants.Nevertheless,theelevationinmucosalLTC4levelfollowing500mL/Lethanoladministrationandundergastritisconditionwassignificantlyreducedbypretreatmentofallthreemildirritantsinbothnormalandgastritisanimals.CONCLUSION:Thesefindingssuggestthattheaggravated500mL/Lethanol-evokedmucosaldamagesundergastritisconditioncouldbeduetoincreasedinducibleNOandLTC4productioninthegastricmucosa.Only200mL/Lethanolistruly'cytoprotective'atthesurfaceglandularlevelofnongastritismucosa.Furthermore,themacroscopicprotectionofthethreemildirritantsinvolvesreductionofLTC4levelinbothnormalandgastritismucosa,implicatingpreservationofthevasculature.

简介：目的:观察针灸治疗萎缩性胃炎的临床疗效.方法:取中脘、足三里穴,用阳中隐阴法治疗38例萎缩性胃炎患者,评定疗效,并与药物组进行疗效比较.结果:针灸组与药物组临床综合疗效比较,有效率分别为81.6%和84.2%,两者统计学处理P＞0.05,临床无显著性差异.结论:表明针灸治疗萎缩性胃炎具有与药物相同的治疗效果.

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简介：Toobservetheeffectofthepointinjectionmethodonthegastricmucosabarrierinratswithchronicatrophicgastritis.Method:RatmodelswithvaryingdegreesofchronicatrophicgastritisweremadeusingMNNGindifferentconcentrations.EqualamountsofHuangqi(RadixAstragali)injectionandDanggui(RadixAngelicaeSinensis)InjectionweremixedandinjectedintothepointZusanli(ST36)

简介：Wehadtreated102casesofobstinatepepticulcerandchronicgastritiswithametalringembeddedinZusanliacupointsinceOctober1989toOctober1992,andgotsatisfactorytherapeuticeffects.Thetotaleffectiverateis96.08%,thecurerateofpepticulceris87.32%,therecurrencerateissignificantlylowerthanthatofcontrolgroup(P<0.001),andithasnoside-effect.

简介：AbstractObjective:The study aimed to detect and analyze long non-coding RNAs (lncRNAs) in plasma of children diagnosed with chronic gastritis, and to explore its biological functions and involved signaling pathways.Methods:The plasma samples were collected from six children that were diagnosed with chronic gastritis by physical examination, gastroscopy, and pathological examination and six healthy children. The plasma samples were assayed for determining the expression profiles of lncRNA based upon the gen chip detection. The specific expression of lcnRNA in plasma of children with chronic gastritis was analyzed and its biological functions were speculated.Results:Five lncRNAs (RP11-697M17.1, RP11-388M20.9, AFAP1-AS1, BC062758, and XLOC001406) were significantly upregulated, and five lncRNAs (UNQ697, BX571672.5, CYP4F35P, ANKRD20A5P, and AL832737) were observed to be significantly down-regulated. The lncRNAs RP11-697M17.1, and UNQ697 were detected with the highest up-regulation and down-regulation, respectively. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis showed that the up-regulated lncRNAs were significantly enriched in 20 signaling pathways such as phosphoinositide-3-kinase-protein kinase B (PI3K-Akt) pathway, and the down-regulated lncRNAs target genes were significantly enriched in 20 signaling pathways such as the metabolic pathway.Conclusion:The analysis of the lncRNA expression profiles in plasma of children with chronic gastritis revealed that the lncRNA RP11-697M17.1, and lncRNA UNQ697 may act as plasma markers for predicting chronic gastritis in children.

简介：Objective:Gastriccancer(GC)isoneoftheleadingcausesofdeathinChinaandotherAsiancountries.Recently,gastricendoscopyhasbecomethemainapproachforGCscreening,buttheidentificationofhigh-riskindividualsremainsachallengeinGCscreeningprograms.Methods:Therewere7,302patientswithchronicgastritisinvolvedinthisstudy.Endoscopicexaminationswereperformed,andtheirdemographiccharacteristicsandlifestyledatawerecollected.EachpossibleassociatedfactorofGC/premalignantandprecursorlesionswasevaluatedbyunivariateandmultivariatelogisticregressions.Nomogramswereusedforvisualizationofthosemodels,andreceiveroperatingcharacteristic(ROC)curveanalysiswasusedtopresentthepredictiveaccuracy.Results:Wedetected8(0.11%)gastricadenocarcinomas,17(0.23%)dysplasiacases,14(0.19%)hyperplasiacases,52(0.71%)intestinalmetaplasiacases,217(2.97%)inflammatorylesions,141(1.93%)gastriculcers,10(0.14%)atrophicgastritiscases,1,365(18.69%)erosivegastritiscases,and5,957(81.58%)superficialgastritiscasesin7,302patients.Theage(P<0.001),gender(P=0.086),laborintensity(P=0.018)andleekfoodintake(P=0.143)wereidentifiedasindependentpredictivefactorsofGC/premalignantlesionspossibility.Thecorrespondingnomogramexhibitedanareaunderthecurve(AUC)[95%confidenceinterval(95%CI)]of0.82(0.74–0.89)forthemodelinggroupand0.80(0.75–0.85)forthevalidationgroup.Theage(P=0.002),gender(P=0.024),smoking(P=0.002)andleekfoodintake(P=0.039)wereindependentpredictivefactorsofprecursorlesionspossibility.ThecorrespondingnomogramexhibitedanAUC(95%CI)of0.62(0.60–0.65)forthemodelinggroupand0.61(0.59–0.63)forthevalidationgroup.Conclusions:WeidentifiedseveralpotentialassociatedfactorsandprovidedapreclinicalnomogramwiththepotentialtopredictthepossibilityofGC/premalignantandprecursorlesions.

简介：Toinvestigatethehistologicalchangeandtheexpressionsofepidermalgrowthfactor(EGF)andepidermalgrowthfactorreceptor(EGFR)inatrophicgastricmucosainratssoastoappraisetheeffectoftheseregulatorsontheformationofatrophicgastritis,tostudytheexpressionsofEGFandEGFRinratswithchronicatrophicgastritis(CAG)aftertheirradiationofHe-Nelaser,andtoinvestigatetherelationsofHe-Nelaserandprecancerouslesionorapoptosis.Theratsweredividedintonormalgroup,modelgroupandlasergroup.ThemodelsofCAGratswereestablishedwithenemawhichwasthemixedliquorconsistedofsodiumsalicylateandalcohol,combinedwithirregularfastingandcompulsivesportingaspathogenicfactors.He-Nelaser(3.36J/cm2)wasusedtoirradiateCAGrats,onceadayfor7min,20daysasacourseoftreatment;theexpressionsofEGFandEGFRweredetectedwithimmunohistochemicalmethod.Duringtheprocessofantralatrophy,theexpressionsofEGFandEGFRincreased,theywerehigherinmodelgroupthanthoseinnormalgroup(P<0.05).AftertheirradiationofHe-Nelaser,theexpressionsofEGFandEGFRwereobviouslylowerthanthoseinmodelgroup(P<0.05).Wedrawtheconclusionasfollows:gastricmucosaofmodelratisinahyper-proliferationstatus,withhighproteinexpressionsofapoptosissuppressorEGFandEGFR.CAGhassomecorrelationwiththeimbalancebetweencellproliferationandapoptosis.He-Nelaser(3.36J/cm2)canreducetheexpressionsofEGFandEGFR,whichisaneffectivephysiostimulatortostimulatethegastricmucosaofrat.TheappropriatesecretionsofEGFandEGFRarepropitioustotherepairandregenerationforthegastricmucosatissues,thuspreventingCAGtocanceration.

简介：ToinvestigatetheprotectiveeffectofdecoctionofliaoweiongastricmucosaofH.pyloriassociatedchronicatrophicgastritisinrats.TheH.pyloriassociatedchronicatrophicgastritismodelswereinducedwithsodiumdeoxycholate,sodiumsalicylate,ethanol,andculturebrothofH.pylori.ProtectiveeffectofdecoctionofliaoweiongastricmucosaofH.pyloriassociatedchronicatrophicgastritiswasobservedquantitatively.

简介：Objective:Tostudytheeffectofthreedifferentmethodssuchasmedicine,acupunctureandlaseracupunctureonthelevelsofinterleukin2(IL-2),interleukin6(IL-6)andtransforminggrowthfactor-β1(TGF-β1)inrat’sserumwithchronicatrophicgastritis.Methods:9ratswererandomlyselectedfrom60ratsasnormalcontrolgroup,andtheotherratswereusedtoreplicatetheanimalmodelofchronicatrophicgastritiswithcomprehensivemethod,5ratswererandomlyinspectedatthe8thweekintheprocessofcreatingmodelforgastricmucosapathologicalexamination;whengastricmucosashowsCAGsymptomssuchasvariousdegreeofcongestion,bleeding,atrophy,metaplasia,themodelratswererandomlydividedintomodelgroup,medicinegroup,acupuncturegroupandlaseracupuncturegroup.TheratsofmedicinegroupwerechronicallyadministeredwithyanshenjianweicapsuleandKangfuxinLiquid;thegroupsofacupunctureandlaseracupunctureselectedZusanliacupunctureasacupuncturepoints,afterthetreatmentfor14d,bloodwasremoved,doubleantibodysandwichenzymelinkedimmunosorbentassay(ELISA)wasusedtodetectthelevelsofIL-2,IL-6andTGF-β1inserum.Results:Comparedwithnormalgroup,thecontentsofIL-2,IL-6andTGF-β1inserumofmodelratsincreased(P<0.05orP<0.01).Medicine,acupunctureandlaseracupuncturecouldreducethecontentsofIL-2,IL-6andTGF-β1,IL-2inserumofthemedicinegroupandlaseracupuncturegroupwassignificantlydecreased(P<0.05);IL-6inacupuncturegroupandlaseracupuncturegroupweresignificantlydecreased(P<0.05orP<0.01);andthemostsignificantislaseracupuncturegroup(P<0.01).Medicine,acupunctureandlaseracupuncturecouldsignificantlyreduceTGF-β1contentinserum(P<0.05orP<0.01),andtheparticularlysignificantwaslaseracupuncture(P<0.01).Conclusion:Laseracupuncturehasthefunctionofreducingtheinflammatoryresponseandadjustingimmunefunction.ItcaneffectivelyreducetheexpressionlevelofIL-2,IL-6andTGF-β1inserumofratswithchronicat