简介:Itiscommonlyseenthatpatientswithbonefractureoftencomplicateotherpartsofinjuriesthatpresentamoreurgentsituationthanfracturesandoftenneedtimelyrecognitionandmanagement.SinceDecember1998,wehavedetectedandanalyzedtheratioofwhitebloodcells(WBC)andhemoglobin(Hb)indiagnosisofcomplicatedinjuriesinpatientswithbonefractureandtrytoraiserescuerateandreducemisseddiagnosisrate.
简介:ObjectToinvestigatetheclinicalsignificanceofallogeneichematopoieticstemcelltransplantation(allo-HSCT)followingfludarabine(Flu)-basednomnyeloablativeconditioningregimen.Methods7patientswitholderageororgandysfunctionreceivedeitheroftwoFlu-basednonmyeloablativeconditioningprotocolsfollowedbyinfusionofgranulocytecolony-stimulatingfactor(G-CSF)mobilizedallogeneicperipheralblooclstemcells(PBSC).Cy-elosporincombiningmethotrexatewasusedasgraftvshostdisease(GVHD)prophylaxis.ResultsMinimalalloHSCTassociatedtoxicitywasfoundapartfrommucositis.Theallogeneicdonorengraftmentswereverifiedinallthepatients.Sixofseveneasessurvivedmorethan5months.AcuteGVHDoccurredinthreeofsevenpatientsincludingacaseofgrade1IGVHD.ConclusionTherapidengrafunentofallo-PBSCandgraftvsleukemia(GVL)effectscanbeobtainedbyFlu-basednomnyeloablativeconditioningregimen.Thismanagementissuitableforthepatientswhoaretoooldorhaveorgandysfunction.
简介:Objective:ToinvestigatetheeffectsofCO2pneumo-peritoneumonbloodflowvolumeofabdominalorgansofrabbitswithcontrolledhemorrhagicshockmodelandliverimpactinjuries.Methods:Aftercontrolledhemorrhagicshockandliverimpactinjuries,therabbitmodelwasestablished.Eighteenrabbitssubjectedtohemorrhagicshockandliverimpactinju-riesweredividedinto3groupsrandomlyaccordingtothevolumeoflostblood:lighthemorrhagicshock(bloodlossvolumewas10%,6ml/kg),moderatehemorrhagicshock(20%,12ml/kg)andseverehemorrhagicshock(40%,22ml/kg).IntraabdominalpressuresofCO2pneumoperitoneumwas10mmHg.Color-labeledmicrosphereswereusedtomea-surethebloodflowvolumeoftheliver,kidneyandstomachbeforepneumoperitoneumat30minutesand2hoursafterpneumoperitoneumand30minutesafterdeflation.Andthemortalityandhepatictraumaticconditionofrabbitswererecorded.Results:Ofthe18rabbits,therewere9withliverimpactinjuriesatGradeⅠ,8atGradeⅡandⅠatGradeⅢ(accordingtoAIS-2005).Themortalityrateinlighthemorrhagicshockgroupwas33.33%,andthatinmoderateorseverehemor-rhagicshockgroupwas100%within30minutesand2hoursafterpneumoperitoneum,respectively.Thebloodflowvol-umeintheorgansdetecteddecreasedat30minutesunderpneumoperitoneuminlightandmoderatehemorrhagicshockgroups.Atthesametime,thebloodflowvolumeoftheliverinmoderatehemorrhagicshockgroupdecreasedmoresig-nificantlythanthatinlighthemorrhagicshockgroup.Conclusions:ThebloodflowvolumeofabdominalorgansinrabbitsisdecreasedobviouslyunderCO2pneumoperitoneum,withfairlyhighmortalityrate.Itisbe-lievedthatCO2pneumoperitoneumshouldcautiouslybeusedinabdominalinjuryaccompaniedwithhemorrhagicshock,especiallyundernon-resuscitationconditions.