简介：4-Amino-5-(pyridin-3-yl)-4H-1,2,4-triazole-3-thiol1werecondensedwith2-bromo-1-(substitutedphenyl)ethanonetogivepyridinyltriazolothiadiazines2a～c,whichwerequaternarizedwithmethyliodideandoxidizedwith30%hydrogenperoxidetoaffordthecorrespondingmethylpyridiniumsalts3a～candpyridine-l-oxides4a～c,respectively.Thereductionofcompounds3and4withNaBH4inmethanolproducedthetargetcompounds1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-6-aryl-s-triazolothiadiazines5a～cand3-(1-hydroxyl-1,2,5,6-tetrahydropyridin-3-yl)-6-aryls-triazolothiadiazines6a～c,respectively.Theendotheliumvascularrelaxingactivityofthetargetcompoundswasscreened.
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