简介：Purpose:Theobjectiveofthepresentstudywastodeterminewhetheradenervatedmuscleextract(DmEx)couldstimulatesatellitecellresponseindenervatedmuscle.Methods:Wistarratsweredividedinto4groups:normalrats,normalratstreatedwithDmEx,denervatedrats,anddenervatedratstreatedwithDmEx.Thesoleusmuscleswereexaminedusingimmunohistochemicaltechniquesforproliferatingcellnuclearantigen,desmin,andmyogenicdifferentiationantigen(MyoD),andelectronmicroscopywasusedforanalysisofthesatellitecells.Results:Theresultsindicatethatwhiledenervationcausesactivationofsatellitecells,DmExalsoinducesmyogenicdifferentiationofcellslocalizedintheinterstitialspaceandtheformationofnewmusclefibers.AlthoughDmExhadasimilareffectinnatureoninnervatedanddenervatedmuscles,thisresponsewasofgreatermagnitudeindenervatedvs.intactmuscles.Conclusion:OurstudyshowsthattreatmentofdenervatedratswithDmExpotentiatesthemyogenicresponseinatrophicdenervatedmuscles.