简介：

简介：摘要：如何使党建精准地推动住房公积金业务开展是一个难题。找准了微党建与住房公积金细分业务的结合点，实现了住房公积金业务的微创新，推动了住房公积金业务的细微改良，具有实际的借鉴意义。

简介：摘要显微计算机断层成像(Micro-CT)是一种新的成像技术，通过简单的对比染色生成软组织的定量、高分辨率、高对比度体积图像，提供无创的显微成像方法，可联合高分辨CT等检查，既得到全身扫描，又可获得重点关注区域的定量、三维、高分辨率成像。在慢性气道疾病患者的早期诊断和治疗后评估中具有重要的研究价值和应用前景。

简介：AbstractBackground:Osteoarthritis (ΟΑ) is characterized by cartilage breakdown and subchondral sclerosis. Micro-fractures of the calcified tissues have been, also, detected, but their exact role has not been elucidated yet. This study was to examine the frequency of cracks during OA progression and to correlate them with the underlying cellular modifications and matrix metalloproteinase-2 (MMP-2) expression using histological/immunohistological methods.Methods:Overall, 20 patients and 3 controls (9 specimens per patient), aged 60-89 years, diagnosed with hip/knee OA were included. The development of cracks was examined in 138 sections, whereas the expression of MMP-2 was examined in 69 additional sections.Results:Based on Mankin score, three groups of OA severity were analyzed: Group I (mild) was constituted of sections with score 1-5 while Groups II (moderate) and III (severe) with score 6-7 and greater or equal to 8, respectively. Demographic characteristics did not reveal any association between the number of microdefects and age or body mass index (BMI). Cartilage micro-cracks were increased during moderate and severe OA, while bone cracks were increased during mild and severe OA. In knee OA, cartilage cracks were not correlated with Mankin score, whereas in hip OA they appeared association with severity score. Bone cracks were positively correlated with matrix apoptotic osteocytes and osteoblastic cells, but not with osteoclasts. MMP-2 immunostaining was increasing by OA severity in the osteochondral unit. Similarly, MMP-2 was expressed on the microcracks’ wall mainly in Group III.Conclusion:Our data displayed that bone cracks during primary OA stages, represent an early adaptative mechanism aiming to maintain cartilage integrity. Accumulation of bone defects and concomitant increase of apoptotic osteocytes activated an abnormal remodeling due to osteoblastic activity, in which MMP-2 played a pivotal role, leading to subchondral sclerosis promoting further osteochondral deformities.

简介：摘要：

简介：摘要：近年来，随着数字技术和开源硬件的普及,小学信息技术教学在内容上发生了很大变化。从教授常用工具软件逐渐转向注重培养创造性思维的创客运动，micro:bit就是这场运动中的佼佼者。本文将从micro:bit的教学背景、实施策略、实施成效三个方面展开介绍。