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简介：AccordingtotheearliesthistoricalbookinChina(Shangshu),duringthereignofEmperorYaomorethan4,000yearsago,peopleincentralplainssufferedfromdiseasessuchasjointpainduetothebadweather.

简介：Cellularmetabolismisaverycomplexprocess.Thebiochemicalpathwaysarefundamentalstructuresofbiology.Thesepathwayspossessanumberofregenerationstepswhichfacilitateenergyshuttlingonamassivescale.Thisfacilitatesthebio-chemicalpathwaystosustaintheenergycurrencyofthecells.Thisconcepthasbeenmimickedusingelectroniccircuitcom-ponentsandithasbeenusedtoincreasetheefficiencyofbio-energygeneration.Sixofthecarbohydratebiochemicalpathwayshavebeenchoseninwhichglycolysisistheprinciplepathway.Allthesixpathwaysareinterrelatedandcoordinatedinacom-plexmanner.Mimiccircuitshavebeendesignedforallthesixbiochemicalpathways.Thecomponentsofthemetabolicpath-wayssuchasenzymes,cofactorsetc.,aresubstitutedbyappropriateelectroniccircuitcomponents.Enzymesarerelatedtothegainoftransistorsbythebonddissociationenergiesofenzyme-substratemoleculesunderconsideration.Cofactorsandcoen-zymesarerepresentedbyswitchesandcapacitorsrespectively.Resistorsareusedforproperorientationofthecircuits.Theenergyobtainedfromthecurrentmethodsemployedforthedecompositionoforganicmatterisusedtotriggerthemimiccir-cuits.Asimilarenergyshuttleisobservedinthemimiccircuitsandthepercentageriseforeachcycleofcircuitfunctioningisfoundtobe78.90.Thetheoreticalcalculationshavebeenmadeusingasampleofdomesticwasteweighing1.182kg.Thecalculationsarrivedatfinallyspeakoftheefficiencyofthenovelmethodologyemployed.

简介：Aroboticfish,BASEMACK1,isdesignedandfabricatedbymimickingtheshapeofalivemackerel.ThreeDCservo-motorsareseriallylinkedtogetherandactuatedtomimicthemackerel'sCarangiformmotion.Hydrodynamiccharac-teristicsofafish-mimetictestmodelareexperimentallyidentifiedandutilizedinordertonumericallysimulatefishswimming.Thediscretesetofkinematicanddynamicparametersareobtainedbyconsideringrequiredhorizontalandlateralforcesandminimumenergyconsumption.Usingtheoptimizedparameterset,optimalcontroloftherobotisstudied.

简介：Thethree-dimensional(3D)structurepredictionofproteinsisanimportanttaskinbioinformatics.Findingenergyfunctionsthatcanbetterrepresentresidue-residueandresidue-solventinteractionsisacrucialwaytoimprovethepredictionaccuracy.Thewidelyusedcontactenergyfunctionsmostlyonlyconsiderthecontactfrequencybetweendifferenttypesofresidues;however,wefindthatthecontactfrequencyalsorelatestotheresiduehydrophobicenvironment.Accordingly,wepresentanimprovedcontactenergyfunctiontointegratethetwofactors,whichcanreflecttheinfluenceofhydrophobicinteractiononthestabilizationofprotein3Dstructuremoreeffectively.Furthermore,afoldrecognition(threading)approachbasedonthisenergyfunctionisdeveloped.Thetestingresultsobtainedwith20randomlyselectedproteinsdemonstratethat,comparedwithcommoncontactenergyfunctions,theproposedenergyfunctioncanimprovetheaccuracyofthefoldtemplatepredictionfrom20%to50%,andcanalsoimprovetheaccuracyofthesequence-templatealignmentfrom35%to65%.

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