简介：Byscanningandtransmissionelectronmicroscopy,leukemlccelbwereobwrvedafterCFU-Mixculture.Eventhoughgranulocytlcgrowthfactor,erythropoietinandlymphocytlcgrowthfactorwereaddedatvitor,acuteleukemlccelbstillshoweddefectsIndifferentiationandmaturation.Thesewerecharacterizedbyabnormalcolonywhichconsistedofsmoothcells,bizarreshape,nuclear-cytoplasmicasynchronyIndevelopment,andappearanceofnuclearbleb.However,chronicmyelogenousleukemlccelbweremorenaturethantheacuteones,manifestinginnormalcolonywithfinger-likeprojectionsandruffledmembrane.Macrophagesandeosinophilscouldbeobserved.ItbsuggestedthattherebadifferenceIndifferentiationbetweenacuteandchronicleukemiacells.

简介：Forelectronicmicroscopicobservation,wefoundSSV-transformedNIH3T3cellsweredifferentfromnon-transformedcells.InSSV-transformedNIH3T3cellsnucleicytoplasmaratiowasincreasedandincytoplasmatheribosomes(polyribosomeswereattachedtotheswollenroughendoplasmicreticulum.Itwaslikelythatribosomeswerelinedtogetherfunctionallyandstructionallytoproducespecificprotein(PDGF-likeprotein).