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简介：Background:Depressiondisordercoexistsinchronicdiseaseswithsomaticdiseasesandhashighmorbidity,disabilityandmortality.Currentresearcheshaveconfirmedthatdepressionmaybecausedbycoronaryheartdisease,hypertensionandheartfailure.Meanwhile,cardiovasculardiseasesmaycauseorworsendepression,leadingtoprolongedhospitalizationandcomplications.

简介：AbstractObjective:The aim of the study is to investigate the relationship between antenatal depression and adverse perinatal outcomes.Methods:This prospective cohort study enrolled pregnant women between gestational ages of 12-20 weeks to complete the Chinese version of the Zung Self-Rating Depression Scale (SDS) and followed them for delivery from September 2015 to September 2016. Participants were classified into mild, moderate, and severe depression groups according to the SDS scores. Logistic regression was performed to assess the association between antenatal depression and perinatal outcomes including preterm birth (PTB), cesarean section use, hypertension disorders, gestational diabetes, and thyroid diseases during pregnancy. An age-stratified analysis was performed.Results:A total of 4,663 pregnant women were analyzed. As a result, 13.8%, 1.7%, and 0.2% of women were classified as mild, moderate, and severe depression, respectively. Severely depressed mothers were at higher risk for PTB (adjusted odds ratio [OR] =11.31, 95% confidence interval [CI] 2.13-60.03), especially spontaneous PTB. Moderate-depressed women were at higher risk for hyperthyroidism during pregnancy (adjusted OR = 3.67, 95% CI 1.10-12.27), while women with mild depression tended to choose cesarean sections (OR = 1.24, 95% CI = 1.04-1.49). Age-stratified analysis indicated an elevated risk of adverse outcomes associated with depression in women aged <25 years, but the association was not significant.Conclusions:Antenatal depression was associated with PTB, hyperthyroidism, and cesarean use. Studies with large sample sizes should verify the relationship between PTB and antenatal depression to avoid casual events.

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简介：AbstractObjective:To measure the prevalence of depression in patients with psoriasis and to evaluate the relationship between the severity of psoriasis and depression and its effect on patients’ quality of life.Methods:A total of 154 patients with a confirmed diagnosis of psoriasis were assessed to determine the severity of psoriasis based on the psoriasis area and severity index score, presence, and severity of depression using the patient health questionnaire 9, and quality of life using the dermatology life quality index 10. Pearson correlation coefficient was used to demonstrate the relationship between continuous variables with 95% confidence intervals (CIs); P < 0.00001 was taken to indicate statistical significance.Results:The severity of psoriasis was mild in 36.36% of patients, moderate in 25.97%, severe in 32.47%, and very severe in 5.20%. Of the 154 patients, 139 (90.3%) had depression; the severity of depression was mild in most affected patients (46.7%) and severe in 2.6% of patients. Psoriasis had a moderate effect on the quality of life in 37.01% of patients and a very large effect in 33.77% of patients. The severity of psoriasis was positively correlated with depression (Pearson correlation coefficient, r= 0.42, P < 0.00001, 95% CI: 0.28-0.54) and quality of life (r= 0.43, P < 0.00001, 95% CI: 0.29-0.55).Conclusion:Depression is a common comorbidity in patients with psoriasis. The severity of psoriasis is positively correlated with the severity of depression and is associated with poor quality of life.

简介：AbstractObjective:Cardiovascular diseases are associated with an increased risk of depression, but it remains unclear whether treatment with cardiovascular agents decreases or increases this risk. The effects of drugs on individual usage are also often unknown. This review aimed to examine the correlation between depression and common cardiovascular drugs, develop more potent interventions for depression in cardiovascular patients, and further research on the bio-behavioural mechanisms linking cardiovascular drugs to depression.Data sources:The data in this review were obtained from articles included in PubMed, EMBASE, and Web of Science.Study selection:Clinical trials, observational studies, review literature, and guidelines about depression and cardiovascular drugs were selected for the article.Results:We systematically investigated whether the seven most used cardiovascular drugs were associated with altered risk of incident depression in this literature review. Statins have been proven to have antidepressant effects. Some studies believe angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptor blocker (ARB) can exert an antidepressant influence by acting on the renin-angiotensin system, but further clinical trials are needed to confirm this. Beta-blockers have previously been associated with depression, but the current study found no significant association between beta blockers and the risk of depression. Aspirin may have antidepressant effects by suppressing the immune response, but its role as an antidepressant remains controversial. calcium channel blockers (CCBs) can regulate nerve signal transduction by adjusting calcium channels, but whether this effect is beneficial or harmful to depression remains unclear. Finally, some cases have reported that nitrates and diuretics are associated with depression, but the current clinical evidence is insufficient.Conclusions:Statins have been proven to have antidepressant effect, and the antidepressant effects of ACEIs/ARB and aspirin are still controversial. CCBs are associated with depression, but it is unclear whether it is beneficial or harmful. No association has been found with β-blockers, diuretics, and nitrates.

简介：Objective:Toinvestigatethedepressionstatusofpatientswithsexuallytransmitteddiseases(STDs).Methods:Thedepressionstatusoffifty-onehospitalizedSTDpatientswasevaluatedinarandomizedcontrolstudyusingZung'sQuantitativeTable.18healthycontrolpatientswithsimilardemographicbackgroundswererandomlychosenascontrols.Patientswithscoresaboveorequalto40wereconsideredtobesufferingfromdepression.Results:Theprevalencerateofdepressioninthepatientgroupwasobviouslyhigherthanthatofinthecontrol(X2=16.456,P<0.01).Prevalenceofdepressionwasfoundtobesignificantlyrelatedtooccupation(P<0.05).Thoughtheprevalencewasnotfoundtodiffersignificantlybetweenthosewithatreatmentcourselessthan2monthsandthosewithonelongerorequalto2months(X2=0.041,P>0.05),themeandepressionscoresoftheformergroupweresignificantlyhigherthanthoseofthelatter(P<0.01).Nosignificantdifferenceswerefoundbetweennewversusrelapsingdisease,marriedversusnon-married,maleversusfemale,ordifferingeducationalbackgrounds.

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简介：Dataontheprevalenceofdepressioninadultcongenitalheartdisease(ACHD)patientsdifferwidely.Weaimtosummarizethebestavailableinformationontheprevalenceofdepression,itsprognosticimpact,andpsychiatricinterventionsfordepressedACHDpatients.WereviewedreferencesinrelevantpublicationsuptoOctober17,2017.Forhomogeneityofdata,studiesinwhichdepressionwasindependentlyassessedinpatientsaged18yearsorolderorwithamean/medianageolderthan18yearswereincluded.Retrospectiveandpostoperativeevaluationstudieswereexcluded.Twentypublicationsmetthesecriteria.StudysamplesincludedACHDpatientsfollowedupatACHD-specializedhospitalsin13countries.Theprevalenceofdepressiondifferedwidely,rangingfrom6to69%.Depressionhasbeenshowntobeanindependentpredictorofadverseclinicaloutcomes.Itisalsofrequentlyassociatedwithotherprognosticvariables(i.e.,poorfunctionalclass,unfavorableperceivedhealthstatus,andlowqualityoflife).Currently,norandomizedclinicaltrialsonpsychiatricinterventionsinACHDareavailable.Insummary,depressionishighlyprevalentinACHDpatients,yetitisoftenunrecognizedanduntreated.Theadverseprognosticimpactofdepressioncallsforspecializedpsychiatricinterventions,forwhichmoreresearchisneededintheACHDpatientpopulation.

简介：AgroupofCanadianphysiciansreportssuccessinthelong-termcontroloftreatment-resistantdepressionbyusingdeepbrainstimulation,buttheyacknowledgethatlongerandlargertrialsarestillneeded.

简介：Cardiovasculardisease(CVD)anddepressionandanxietycontributesubstantiallytothecurrentdiseaseburdenworldwideaswellasinChina.BothdepressionandanxietyarehighlyprevalentamongpatientswithCVD.WesystematicallyreviewedtheliteraturetodisentangletheroleofdepressionandanxietydisordersintheonsetandprognosisofCVDwithanemphasisoncohortstudiesconductedintheChinesepopulation.Despitethelackoflarge-scaleprospectivestudiesinChina,theavailableevidenceimpliesthatbothdepressionandanxietyarecloselyassociatedwiththeonsetandprognosisofCVD,includingischemicheartdiseaseandstroke,inChineseadults.Putativebehavioralandbiologicalmechanismsareimplicatedinthelinkbetweendepression/anxietyandCVD.TimelyscreeninganddiagnosisfollowedbypropertreatmentshouldbeimplementedfordepressionandanxietyinboththegeneralpopulationandpatientswithCVD.CurrentstandardtreatmentssuchasselectiveserotoninreuptakeinhibitorsandpsychotherapiesarerecommendedforCVDpatientswithdepression,althoughtheirefficacyforreducingCVDmorbidityandmortalityremainsuncertain.Inconclusion,prospectivestudiesonthelinkbetweendepression/anxietyandtheonsetandprognosisofCVDareurgentlyneededintheChinesepopulation,andmoreeffortsarewarrantedtoexaminetheefficacyofdepressionandanxietytreatmentsforCVDpatients,particularlytheintegratedcaremodelofincludingpsychiatristsinamultidisciplinaryclinicalgroup.

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简介：目的：观察电针对中风后抑郁患者抑郁情绪及神经功能缺损程度的影响。方法：选择经临床、CT或MRHY-实的中风患者90例，按随机数字表分为3组，每组30例。三组患者均给予中风常规治疗，电针组加用电针，西药组加用氟西汀，对照组加用安慰剂，连续60d。结果：与对照组比较，电针组、西药组患者的汉密尔顿抑郁量表（HamiltonDepressionRatingScale，HAMD）和改良爱丁堡－斯堪的纳维亚评分（ModifiedEdinburgh—ScandinaviaStrokeScale，MESSS）下降，Barthel指数评分上升（P〈0．05）；电针组、西药组总体疗效无显著差异，电针组、西药组总体疗效优于对照组。结论：电针能改善抑郁表现，促进神经功能康复。

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简介：TheSeaofOkhotskdepressionastheoil-gas-bearingstructurealwaysattractedattcntionofgeolo-gists.Muehworkofclassicalcharacter,devotedtothestudyofitsstructural-geologicalandgeomor-phicpattern,hasbeenconduetedinitsframework.Duringtherecentyearsanewapproach-morpbostructuralanalysishasbeenwidelyusedinthestud

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简介：Aheavyrainfallassociatedwiththedeepeningofamonsoondepressionhappenedinthesummerof2005.Thisprocesswasfirstdiagnosticallyanalyzedandthe3Dstructureofthemonsoondepressionwasdiscussed,thenthisstructurewascomparedwiththoseofthemonsoondepressioninSouthAsiaandthelowvortexintheMeiyufront.TheresultsshowedthattheheavyrainfalldirectlyresultedfromamonsoondepressioninSouthChina,andthelarge-scaleenvironmentprovidedafavorablebackgroundforthedeepeningofthemonsoondepression.The3Dstructureofthemonsoondepressionwasasfollows.Inthehorizontaldirection,thereexistedaconvectivecloudbandtothesouthofthemonsoondepression,whichlayinaconvectivelyinstablearea,witharelativelystrongascendingmotioninthemidandlowlevelsofthetroposphere,andtheascendingmotionmatchedwellwithamoisttongue,aconvergencearea,andabandofpositivevorticityinthemidandlowlevelsofthetroposphere.Intheverticaldirection,thedepressionhadanobviouslycycloniccirculationinthemidandlowlevelsofthetroposphere,butnocirculationfromabove300hPa.Themonsoondepressioncorrespondedtoconvergenceandpositivevorticityinthelowlevels,buttodivergenceandnegativevorticityintheupperlevels.Theupwarddraftofthedepressioncouldreachtheupperlevelsofthetroposphereinthewestofthedepression,whilethedescendingmotionlayintheeast.Therewasalow-leveljettothesouthofthedepression,whiletheupper-leveljetwasnotobvious.Thedepressionwasverticallywarmintheupperlevelsandcoldinthelowlevels,andtheaxisofthedepressiontiltedsoutheastwardwithheight,whosecharacteristicsweredifferentnotonlyfromthemonsoondepressioninSouthAsiabutalsofromthelowvortexintheMeiyufront.

简介：为产后的消沉加心理干预观察针灸的治疗学的效果。

简介：SubmarinelandslideshavebeenobservedintheBaiyunDepressionoftheSouthChinaSea.Theoccurrenceofhydratesbelowtheselandslidesindicatesthattheseslopeinstabilitiesmaybecloselyrelatedtothemassivereleaseofmethane.Inthisstudy,weusedasimpleMonte-Carlomodeltodeterminethefirst-orderdeformationpatternofagravitationallydestabilizingslope.Theresultsshowthatastressconcentrationoccursduetohydratedissociationonthenearbyglidesurfaceandontopofagaschimneystructure.Uponthedissolutionofthegashydrate,slopefailureoccursduetotheexcessporepressuregeneratedbythedissociationofthegashydrates.Whengashydratesdissociateatshallowdepths,theexcessporepressuregeneratedcanbegreaterthanthetotalstressactingatthosepoints,alongwiththeforcesthatresistsliding.Initially,thefailureoccursatthetoeoftheslope,thenextendstotheinterior.Althoughourinvestigationfocusedonlyonthecontributionofhydratedecompositiontosubmarinelandslide,thisprocessisalsoaffectedbyboththeslopematerialpropertiesandtopography.